The COVID-19 pandemic has emerged as a global health emergency due to its association with severe pneumonia and relative high mortality.However,the molecular characteristics and pathological features underlying COVID-...The COVID-19 pandemic has emerged as a global health emergency due to its association with severe pneumonia and relative high mortality.However,the molecular characteristics and pathological features underlying COVID-19 pneumonia remain largely unknown.To characterize molecular mechanisms underlying COVID-19 pathogenesis in the lung tissue using a proteomic approach,fresh lung tissues were obtained from newly deceased patients with COVID-19 pneumonia.After virus inactivation,a quantitative proteomic approach combined with bioinformatics analysis was used to detect proteomic changes in the SARS-CoV-2-infected lung tissues.We identified significant differentially expressed proteins involved in a variety of fundamental biological processes including cellular metabolism,blood coagulation,immune response,angiogenesis,and cell microenvironment regulation.Several inflammatory factors were upregulated,which was possibly caused by the activation of NF-κB signaling.Extensive dysregulation of the lung proteome in response to SARS-CoV-2 infection was discovered.Our results systematically outlined the molecular pathological features in terms of the lung response to SARS-CoV-2 infection,and provided the scientific basis for the therapeutic target that is urgently needed to control the COVID-19 pandemic.展开更多
Dear editor,Mycosis fungoides(MF),the most common subtype of cutaneous T cell lymphoma,is a rare disease[1,2].Patients with early-stageMF have a 5-year overall survival between 88%and 100%[3].In patients with advanced...Dear editor,Mycosis fungoides(MF),the most common subtype of cutaneous T cell lymphoma,is a rare disease[1,2].Patients with early-stageMF have a 5-year overall survival between 88%and 100%[3].In patients with advanced MF,the skin may present with tumors and erythroderma,and the median survival of patients with lymph node and visceral metastasis is 13 months[4].Therefore,it is important to achieve an early diagnosis to improve prognosis[5].展开更多
Dear Editor,Almost one-half of COVID-19 patients have symptoms of liver injury.However,the molecular characteristics in the COVID-19 liver remain unknown.Therefore,the need for long-term medication for recovery make i...Dear Editor,Almost one-half of COVID-19 patients have symptoms of liver injury.However,the molecular characteristics in the COVID-19 liver remain unknown.Therefore,the need for long-term medication for recovery make it imperative to study the infectivity and pathogenicity of SARS-CoV-2 in the liver.Here,we have identifed signifcant proteomic changes for the first time in the liver of COVID-19 patients.We detected differential expression levels of several proteins that mediate characteristic cellular host responses elicited by SARS-CoV-2 infection in the liver.展开更多
基金supported by the National Science and Technology Major Projects(2018ZX09711003).
文摘The COVID-19 pandemic has emerged as a global health emergency due to its association with severe pneumonia and relative high mortality.However,the molecular characteristics and pathological features underlying COVID-19 pneumonia remain largely unknown.To characterize molecular mechanisms underlying COVID-19 pathogenesis in the lung tissue using a proteomic approach,fresh lung tissues were obtained from newly deceased patients with COVID-19 pneumonia.After virus inactivation,a quantitative proteomic approach combined with bioinformatics analysis was used to detect proteomic changes in the SARS-CoV-2-infected lung tissues.We identified significant differentially expressed proteins involved in a variety of fundamental biological processes including cellular metabolism,blood coagulation,immune response,angiogenesis,and cell microenvironment regulation.Several inflammatory factors were upregulated,which was possibly caused by the activation of NF-κB signaling.Extensive dysregulation of the lung proteome in response to SARS-CoV-2 infection was discovered.Our results systematically outlined the molecular pathological features in terms of the lung response to SARS-CoV-2 infection,and provided the scientific basis for the therapeutic target that is urgently needed to control the COVID-19 pandemic.
基金This work was supported by the National Natural Science Foundation of China(No.82173449)the Beijing Nature Science Foundation(No.7182127),the Nonprofit Central Research Institute Fund of Chinese Academy of Medical Sciences(No.2019XK320024)+1 种基金the National Key Research and Development Program of China(No.2016YFC0901500)the Medical and Health Science and Technology Innovation Project of Chinese Academy of Medical Sciences(2019-I2M-1-001).
文摘Dear editor,Mycosis fungoides(MF),the most common subtype of cutaneous T cell lymphoma,is a rare disease[1,2].Patients with early-stageMF have a 5-year overall survival between 88%and 100%[3].In patients with advanced MF,the skin may present with tumors and erythroderma,and the median survival of patients with lymph node and visceral metastasis is 13 months[4].Therefore,it is important to achieve an early diagnosis to improve prognosis[5].
基金This work was supported by the National Science and Technology Major Projects(2018ZX09711003)National Key Research and Development Project(2020YFC0841700)Ministry of Science and Technology of P.R.China Plan(2020YFC0844700).
文摘Dear Editor,Almost one-half of COVID-19 patients have symptoms of liver injury.However,the molecular characteristics in the COVID-19 liver remain unknown.Therefore,the need for long-term medication for recovery make it imperative to study the infectivity and pathogenicity of SARS-CoV-2 in the liver.Here,we have identifed signifcant proteomic changes for the first time in the liver of COVID-19 patients.We detected differential expression levels of several proteins that mediate characteristic cellular host responses elicited by SARS-CoV-2 infection in the liver.
