目的分析2014—2018年辽宁省男男性行为(men who have sex with men,MSM)人群抗逆转录病毒治疗失败病例HIV-1基因型耐药特征,探讨失败的原因和药物敏感性,指导临床个性化诊疗。方法募集2014—2018年辽宁省MSM人群接受抗逆转录病毒治疗...目的分析2014—2018年辽宁省男男性行为(men who have sex with men,MSM)人群抗逆转录病毒治疗失败病例HIV-1基因型耐药特征,探讨失败的原因和药物敏感性,指导临床个性化诊疗。方法募集2014—2018年辽宁省MSM人群接受抗逆转录病毒治疗半年后的病例,对HIV-1病毒载量≥1000 copies/mL的样本用RT-PCR法进行HIV-1 pol基因检测。对获得的pol基因序列进行亚型判定用Stanford University HIV-1耐药数据库进行基因型耐药解析。用SPSS软件进行统计分析。结果2014—2018年共发现辽宁省MSM人群抗逆转录病毒治疗病毒学失败病例400例,CRF01_AE为最主要流行毒株,约占83.8%;其中267例(66.8%)存在耐药相关突变并对一线药物存在低度及以上耐受。最主要受累群体为25~45岁年龄段病例,72.0%的病例在治疗后0.5~2.0年被检出,87.6%的耐药病例(234/267)同时对核苷类和非核苷类逆转录酶抑制剂耐药。结论抗逆转录病毒治疗失败病例主要由耐药相关突变引起的;在扩大治疗防控策略背景下,加强初始治疗病例依从性教育,减少治疗后耐药发生,必要时可以加强治疗后随访检测,识别治疗失败病例,及时优化治疗方案,提高治疗成功率。展开更多
Suppressor of cytokine signaling 3 （SOCS3） proteins, a Pmember of SOCS family, are predominantly expressed in Th2 cells, and it has an important role in regulating the onset and maintenance of Th2-mediated allergic ...Suppressor of cytokine signaling 3 （SOCS3） proteins, a Pmember of SOCS family, are predominantly expressed in Th2 cells, and it has an important role in regulating the onset and maintenance of Th2-mediated allergic immune disease.1 SOCS can translocate from cytoplasm to nucleus when the level in cytoplasm increases, and localize to cell membrane where it binds to receptors. However, to our knowledge, there has been no documentation whether SOCS can transport to the intercellular space or circulating body fluids, let alone the subsequent biological significance. Signal transducer and activator of transcription （STAT） proteins, a group of transcription factor, are critical for mediating signals during Thl, Th2,展开更多
文摘目的分析2014—2018年辽宁省男男性行为(men who have sex with men,MSM)人群抗逆转录病毒治疗失败病例HIV-1基因型耐药特征,探讨失败的原因和药物敏感性,指导临床个性化诊疗。方法募集2014—2018年辽宁省MSM人群接受抗逆转录病毒治疗半年后的病例,对HIV-1病毒载量≥1000 copies/mL的样本用RT-PCR法进行HIV-1 pol基因检测。对获得的pol基因序列进行亚型判定用Stanford University HIV-1耐药数据库进行基因型耐药解析。用SPSS软件进行统计分析。结果2014—2018年共发现辽宁省MSM人群抗逆转录病毒治疗病毒学失败病例400例,CRF01_AE为最主要流行毒株,约占83.8%;其中267例(66.8%)存在耐药相关突变并对一线药物存在低度及以上耐受。最主要受累群体为25~45岁年龄段病例,72.0%的病例在治疗后0.5~2.0年被检出,87.6%的耐药病例(234/267)同时对核苷类和非核苷类逆转录酶抑制剂耐药。结论抗逆转录病毒治疗失败病例主要由耐药相关突变引起的;在扩大治疗防控策略背景下,加强初始治疗病例依从性教育,减少治疗后耐药发生,必要时可以加强治疗后随访检测,识别治疗失败病例,及时优化治疗方案,提高治疗成功率。
文摘Suppressor of cytokine signaling 3 （SOCS3） proteins, a Pmember of SOCS family, are predominantly expressed in Th2 cells, and it has an important role in regulating the onset and maintenance of Th2-mediated allergic immune disease.1 SOCS can translocate from cytoplasm to nucleus when the level in cytoplasm increases, and localize to cell membrane where it binds to receptors. However, to our knowledge, there has been no documentation whether SOCS can transport to the intercellular space or circulating body fluids, let alone the subsequent biological significance. Signal transducer and activator of transcription （STAT） proteins, a group of transcription factor, are critical for mediating signals during Thl, Th2,
