Three patients with acute multiple cranial neuropathy following benign infecti ous disease are reported. Complete or partial ophthalmoplegia, as well as facial and bulbar dysfunction, were noted in all. Cranial nerve ...Three patients with acute multiple cranial neuropathy following benign infecti ous disease are reported. Complete or partial ophthalmoplegia, as well as facial and bulbar dysfunction, were noted in all. Cranial nerve involvement was bilate ral. Otherneu rological deficits included sensory loss in two patients and transiently reduced tendon reflexes in the left arm in one. One patient had positive serum anti GQ 1b immunoglobulin G antibody during the acute phase of the illness. The cerebros pinal fluid had a normal cell count in all three patients, with raised protein c oncentrations in two. Electrophysiological evaluation showed peripheral nerve dy sfunction in two patients. All three patients improved either spontaneously or c oincident with immunotherapy. Our patients had many clinical features resembling those of typical Guillain Barrésyndrome (GBS), and hence their disorder may r epresent a regional variant, that is, a cranial form, of GBS. This form of GBS a ccounted for 5%of the GBS patient population in our series.展开更多
文摘Three patients with acute multiple cranial neuropathy following benign infecti ous disease are reported. Complete or partial ophthalmoplegia, as well as facial and bulbar dysfunction, were noted in all. Cranial nerve involvement was bilate ral. Otherneu rological deficits included sensory loss in two patients and transiently reduced tendon reflexes in the left arm in one. One patient had positive serum anti GQ 1b immunoglobulin G antibody during the acute phase of the illness. The cerebros pinal fluid had a normal cell count in all three patients, with raised protein c oncentrations in two. Electrophysiological evaluation showed peripheral nerve dy sfunction in two patients. All three patients improved either spontaneously or c oincident with immunotherapy. Our patients had many clinical features resembling those of typical Guillain Barrésyndrome (GBS), and hence their disorder may r epresent a regional variant, that is, a cranial form, of GBS. This form of GBS a ccounted for 5%of the GBS patient population in our series.
