It is a challenging task to prepare a coating on Mg alloys for desirable corrosion resistance,good antibac-terial ability and biocompatibility.In this research work,an in-situ Mg(OH)_(2)coating incorporated with sodiu...It is a challenging task to prepare a coating on Mg alloys for desirable corrosion resistance,good antibac-terial ability and biocompatibility.In this research work,an in-situ Mg(OH)_(2)coating incorporated with sodium alginate(SA)andβ-cyclodextrin(β-CD)@curcumin(Cur)was formed on the surface of micro arc oxidation(MAO)coated AZ31 alloy via a low temperature hydrothermal method.Characterization tech-niques such as X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),Fourier transform infrared spectrometer(FT-IR)and scanning electron microscope(SEM)were employed to characterize the chemi-cal composition and surface morphology of the coatings.The corrosion protection ability of the coatings was monitored via electrochemical polarization,hydrogen evolution and immersion tests.Photothermal antibacterial ability and cytocompatibility of the coatings were evaluated by plate counting method under the irradiation of 808 nm-near infrared light,in vitro cytotoxicity tests(MTT)and live/dead cell staining.The results indicate that a chelation of the organic molecules led to the formation of a MAO/(β-CD@Cur)-SA-Mg(OH)_(2)coating with excellent corrosion protection,multi-antibacterial ability and almost no toxic-ity to the cells.Especially,the coating provided photothermal performance through the light absorption of Cur,which was encapsulated byβ-CD to improve its bioavailability.SA enhanced the binding force between the drug and the substrate.This novel coating designated the potential application on bioab-sorbable magnesium alloys.展开更多
基金supported by the National Natural Science Foun-dation of China(Nos.52071191 and No.52101288)Shandong Provincial Natural Science Foundation(No.ZR2020QE009).
文摘It is a challenging task to prepare a coating on Mg alloys for desirable corrosion resistance,good antibac-terial ability and biocompatibility.In this research work,an in-situ Mg(OH)_(2)coating incorporated with sodium alginate(SA)andβ-cyclodextrin(β-CD)@curcumin(Cur)was formed on the surface of micro arc oxidation(MAO)coated AZ31 alloy via a low temperature hydrothermal method.Characterization tech-niques such as X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),Fourier transform infrared spectrometer(FT-IR)and scanning electron microscope(SEM)were employed to characterize the chemi-cal composition and surface morphology of the coatings.The corrosion protection ability of the coatings was monitored via electrochemical polarization,hydrogen evolution and immersion tests.Photothermal antibacterial ability and cytocompatibility of the coatings were evaluated by plate counting method under the irradiation of 808 nm-near infrared light,in vitro cytotoxicity tests(MTT)and live/dead cell staining.The results indicate that a chelation of the organic molecules led to the formation of a MAO/(β-CD@Cur)-SA-Mg(OH)_(2)coating with excellent corrosion protection,multi-antibacterial ability and almost no toxic-ity to the cells.Especially,the coating provided photothermal performance through the light absorption of Cur,which was encapsulated byβ-CD to improve its bioavailability.SA enhanced the binding force between the drug and the substrate.This novel coating designated the potential application on bioab-sorbable magnesium alloys.
