Role of intravenously administered hyoscine butyl bromide in retrograde terminal ileoscopy: A randomized, double-blinded, placebo-controlled trial

AIM: To evaluate the role of hyoscine butyl bromide in facilitating retrograde ileoscopy.METHODS: Retrograde terminal ileoscopy was attempted in 200 consecutive patients undergoing colonoscopy. After intubation of the cecum and visualization of the ileocecal valve, hyoscine butyl bromide injection or normal saline was given intravenously to the patients in a double blind random fashion. The pulse rate and oxygen saturation were measured continuously. After completion of the procedure, endoscopists were then asked to score the ease of intubation and the ease of visualization of the terminal ileum on a visual scale of 1 to 10. The patients were also asked to score the pain after receiving hyoscine butyl bromide injection on a score of 1 to 10.RESULTS: Terminal ileoscopy could be performed in 188 patients. The mean (SD) visual analogue score for the ease of intubation of the cecum was 7.4 (0.65) in the injection group and 5.9 (0.8) in the placebo group (P < 0.001). The mean (SD) length of ileum visualized in the injection group was 14.4 (3.3) cm and 10.4 (2.7) cm in the placebo group (P < 0.001). The mean (SD) visual analogue score for ease of visualization of the terminal ileum was 7.5 (0.69) in the injection group and 5.9 (0.7) in the placebo group (P < 0.001). The pain score experienced by the patients was 6.5 (0.7) in the injection group and 6.7 (0.69) in the placebo group (P < 0.008). Although the pulse rate increased significantly in patients receiving the drug, no statistically significant difference was noted in the oxygen saturation between the two groups either before or after administration of the drug. No complications were observed in either of the groups.CONCLUSION: Hyoscine butyl bromide injection is a useful adjunct in helping the intubation and visualization of terminal ileum during colonoscopy.

Ileoscopy in 39 hematochezia patients with normal colonoscopy

瞄准：估计角色后退在有正常结肠镜检查的便血病人的终端 ileoscopy。方法：在 1997 年 1 月和 2005 年 3 月之间， 39 个便血病人(男性 36，女性 3，意味着年龄 44.7 年) 与报导正常，结肠镜检查经历了重复结肠镜检查。在到达盲肠以后，被尝试本地化回盲肠阀门和 intubate 终端回肠。在终端回肠的粘膜的任何反常小心地被记录，活体检视从看似可疑的损害被获得。结果：在学习时期期间，有 39 个病人，为结肠镜检查没在揭示任何反常到盲肠为止的便血招收。全身的结肠镜检查能在所有病人被执行到盲肠为止。终端回肠能在 36 个病人被把管子插进。没有反常在 31 个病人被注意。回肠溃疡在二个病人被注意。与 i 的溃疡一起的 Nodularity 忠实粘膜， Dieulafoy 的损害，和血管瘤的畸形性各在一个病人被注意。从溃疡获得的活体检视的组织学的检查与 nodularity 和溃疡在病人揭示了典型有结节的损害。病人之一有伤寒的溃疡，另外一个有非特定的溃疡。结论：后退终端 ileoscopy 给有限却珍贵的信息，在有便血的病人并且应该在所有被尝试如此的病人。