Neurodegenerative disorders are characterized by disruptions to neuronal function and circuitry,leading to a variety of clinical syndromes depending on the affected neuroanatomic regions(Geula,1998).Many proteinopathi...Neurodegenerative disorders are characterized by disruptions to neuronal function and circuitry,leading to a variety of clinical syndromes depending on the affected neuroanatomic regions(Geula,1998).Many proteinopathies implicated in neurodegenerative diseases are characterized by the pathologic accumulation of proteins into inclusions that are initially deposited in specific areas of the brain and spread widely with disease progression.展开更多
基金supported by grants from the National Institute of Neurological Disorders and Stroke,No.NS085770National Institute on Deafness and Other Communication Disorders No.DC008552+2 种基金National Institute on Aging,No.AG062566 and AG065463an institutional training grant from the National Institute of Neurological Disorders and Stroke,No.NS047987an Alzheimer’s Disease Center Grant from the National Institute on Aging,No.AG013854。
文摘Neurodegenerative disorders are characterized by disruptions to neuronal function and circuitry,leading to a variety of clinical syndromes depending on the affected neuroanatomic regions(Geula,1998).Many proteinopathies implicated in neurodegenerative diseases are characterized by the pathologic accumulation of proteins into inclusions that are initially deposited in specific areas of the brain and spread widely with disease progression.
