Porcine α-1 acid glycoprotein (AGP) in newborn pigs can be used to predict growth rate through weaning and is a marker for growth impairment. This study examined whether nutritional support can improve the growth rat...Porcine α-1 acid glycoprotein (AGP) in newborn pigs can be used to predict growth rate through weaning and is a marker for growth impairment. This study examined whether nutritional support can improve the growth rate of piglets identified as having poor growth potential. Cross-fostering (CF) and CF plus a milk supplement (CF + MS) were used to attempt to improve the growth performance of pigs. Blood was collected at d1 post-parturition for measurement of plasma AGP for all pigs in 28 litters contributing to the experiment. Piglets with the highest plasma AGP level were weight and sex matched to a littermate with a low plasma AGP concentration and four pairs of these weight and sex matched pigs were grouped into four foster litters per treatment (control, CF, CF + MS). The control group was assembled by pairing littermates remaining in donor litters. Pigs stayed on treatment until weaning at 21 days of age. At 35 days of age, dual energy X-ray absorptiometry (DXA) was performed on CF and CF + MS pigs to evaluate carcass composition. Control pairs differed in weaning weight, with pigs with higher plasma AGP at 1 day of age having smaller weaning weights than their littermates of similar birth weight (P < 0.05). However, CF eliminated the difference in weaning weight between the slow growing pigs and their birth weight matched littermates. CF + MS produced a similar effect as CF (P > 0.05). At 35 days of age, body weights were still similar between CF littermates and between CF + MS littermates (P > 0.05). DXA analysis demonstrated that body composition was similar between CF or CF + MS treated pigs and their littermates. These data demonstrate that CF can be used to correct the growth impairment in pigs predicted using plasma AGP as the marker. CF + MS can do the same, but at greater expense.展开更多
Growth rate affects adipose tissue development and variations in growth rate may potentially impact adipokine expression. Samples of subcutaneous (SQ) and perirenal (PR) adipose tissues and longissimus muscle were col...Growth rate affects adipose tissue development and variations in growth rate may potentially impact adipokine expression. Samples of subcutaneous (SQ) and perirenal (PR) adipose tissues and longissimus muscle were collected at day 21 of age from the fastest and slowest growing piglets within seven litters. Reverse transcription and real-time PCR were used to quantify adipokine mRNA abundance. Leptin, adiponectin, tumor necrosis factor α (TNFα ) and lipoprotein lipase (LPL) mRNA abundance were lower in SQ from slow growing piglets (SGP) than in fast growing piglets (FGP, P α gene expression were reduced in PR from SGP in comparison to FGP (P β (IL1β), IL15 and LPL were increased in the longissimus of SGP relative to FGP (P < 0.05). Analysis of mRNA abundance for these adipokines within adipose tissue at day 21 of age demonstrated that the effect of growth rate on adipokine expression varies among different adipokines and the internal and external sites of adipose tissue deposition (PR versus SQ). The increase in longissimus expression of LPL and IL15 suggests that nutrient partitioning for energy use may be greater in the skeletal muscle of the SGP.展开更多
文摘Porcine α-1 acid glycoprotein (AGP) in newborn pigs can be used to predict growth rate through weaning and is a marker for growth impairment. This study examined whether nutritional support can improve the growth rate of piglets identified as having poor growth potential. Cross-fostering (CF) and CF plus a milk supplement (CF + MS) were used to attempt to improve the growth performance of pigs. Blood was collected at d1 post-parturition for measurement of plasma AGP for all pigs in 28 litters contributing to the experiment. Piglets with the highest plasma AGP level were weight and sex matched to a littermate with a low plasma AGP concentration and four pairs of these weight and sex matched pigs were grouped into four foster litters per treatment (control, CF, CF + MS). The control group was assembled by pairing littermates remaining in donor litters. Pigs stayed on treatment until weaning at 21 days of age. At 35 days of age, dual energy X-ray absorptiometry (DXA) was performed on CF and CF + MS pigs to evaluate carcass composition. Control pairs differed in weaning weight, with pigs with higher plasma AGP at 1 day of age having smaller weaning weights than their littermates of similar birth weight (P < 0.05). However, CF eliminated the difference in weaning weight between the slow growing pigs and their birth weight matched littermates. CF + MS produced a similar effect as CF (P > 0.05). At 35 days of age, body weights were still similar between CF littermates and between CF + MS littermates (P > 0.05). DXA analysis demonstrated that body composition was similar between CF or CF + MS treated pigs and their littermates. These data demonstrate that CF can be used to correct the growth impairment in pigs predicted using plasma AGP as the marker. CF + MS can do the same, but at greater expense.
文摘Growth rate affects adipose tissue development and variations in growth rate may potentially impact adipokine expression. Samples of subcutaneous (SQ) and perirenal (PR) adipose tissues and longissimus muscle were collected at day 21 of age from the fastest and slowest growing piglets within seven litters. Reverse transcription and real-time PCR were used to quantify adipokine mRNA abundance. Leptin, adiponectin, tumor necrosis factor α (TNFα ) and lipoprotein lipase (LPL) mRNA abundance were lower in SQ from slow growing piglets (SGP) than in fast growing piglets (FGP, P α gene expression were reduced in PR from SGP in comparison to FGP (P β (IL1β), IL15 and LPL were increased in the longissimus of SGP relative to FGP (P < 0.05). Analysis of mRNA abundance for these adipokines within adipose tissue at day 21 of age demonstrated that the effect of growth rate on adipokine expression varies among different adipokines and the internal and external sites of adipose tissue deposition (PR versus SQ). The increase in longissimus expression of LPL and IL15 suggests that nutrient partitioning for energy use may be greater in the skeletal muscle of the SGP.