Extensive research in the area of optical sensing for medical diagnostics requires development of tissue phantoms with opt ical properties similar to those of living human tissues.Development and improvement of in viv...Extensive research in the area of optical sensing for medical diagnostics requires development of tissue phantoms with opt ical properties similar to those of living human tissues.Development and improvement of in vivo optical measurement systems requires the 1use of stable tissue phantoms with known characteristics,which are mainly used for calibration of such systems and testing their performance over time.Optical and mechanical properties of phantoms depend on their purpose.Nevertheless,they must accurately simulate specific tssues they are supposed to mimic.Many tsues and organs including head possess a multi-layered structure,with specifie optical properties of each layer.However,such a structure is not always addressed in the present-day phantoms.In this paper,we focus on the development of a plain-parallel multi-layered phantom with optical properties(reduced scattering oofficientμ'and absorption cofficientμa)corresponding to the human head layers,such as skin,skul,and gray and white matter of the brain tissue.The phantom is intended for use in noninvasive diffuse near-infrared spectroscopy(NIRS)of humnan brain.Optical parameters of the fabricated phantoms are reconstructed using spectrophotometry and inverse adding-doubling calculation method.The results show that polyinyl chloride plastisol(PVCP)and zinc oxide(ZnO)nanoparticles are suitable materials for fabrication of tissue mimicking phantoms with controlled scattering properties.Good matching was found between optical properties of phantoms and the corresponding values found in the literature.展开更多
基金the National Science Center,Poland funding allocated on the basis of the decision number DEC-20011/03/D/ST7/03540Foundation for Polish Science under Grant No.173/UD/SKILLS/2012+3 种基金DS Programs of the Faculty of Electronics,Telecommunications and Informatics,Gdańsk University of TechnologyEuropean Cooperation in Science and Technology (COST)Action BM1205FiDiPro project 40111/11,TEKES (Finnish Funding Agency for Technology and Innovation)Government of the Russian Federation (Grant No.14.Z50.31.0004 to support scientic research projects implemented under the supervision of leading scientists)and Russian Presidential grant NSh-703.2014.2.
文摘Extensive research in the area of optical sensing for medical diagnostics requires development of tissue phantoms with opt ical properties similar to those of living human tissues.Development and improvement of in vivo optical measurement systems requires the 1use of stable tissue phantoms with known characteristics,which are mainly used for calibration of such systems and testing their performance over time.Optical and mechanical properties of phantoms depend on their purpose.Nevertheless,they must accurately simulate specific tssues they are supposed to mimic.Many tsues and organs including head possess a multi-layered structure,with specifie optical properties of each layer.However,such a structure is not always addressed in the present-day phantoms.In this paper,we focus on the development of a plain-parallel multi-layered phantom with optical properties(reduced scattering oofficientμ'and absorption cofficientμa)corresponding to the human head layers,such as skin,skul,and gray and white matter of the brain tissue.The phantom is intended for use in noninvasive diffuse near-infrared spectroscopy(NIRS)of humnan brain.Optical parameters of the fabricated phantoms are reconstructed using spectrophotometry and inverse adding-doubling calculation method.The results show that polyinyl chloride plastisol(PVCP)and zinc oxide(ZnO)nanoparticles are suitable materials for fabrication of tissue mimicking phantoms with controlled scattering properties.Good matching was found between optical properties of phantoms and the corresponding values found in the literature.
