Background:Scabies is a very common skin infection in convicts.The SIMSPE Society(SocietItaliana di Medicina e Sanit`a Penitenziaria)has organized and conducted a multicentre,randomized,comparative,parallel group,in...Background:Scabies is a very common skin infection in convicts.The SIMSPE Society(SocietItaliana di Medicina e Sanit`a Penitenziaria)has organized and conducted a multicentre,randomized,comparative,parallel group,investigator-blinded trial to evaluate the efficacy and tolerability of synergized pyrethrins foam(PF)in comparison with benzyl benzoate(BB)lotion.Methods:A total of 240 convicted patients,enrolled in eight National Jail Institutions,with a clinical diagnosis of scabies,were treated with PF(n = 120)for three consecutive days or BB(n = 120)for five consecutive days.Primary study endpoints were the clinical cure rate and the local tolerability.Secondary endpoints were clinical evolution of scabietic lesions and itching intensity.Study outcomes were assessed using appropriate semiquantitative scores at baseline and after 2 and 4 weeks.A second treatment cycle was applied if after 2 weeks the patient was not judged clinically cured.Results:At week 2,a total of 75%(95 %CI:66-82%)and 71%(95%CI:62-78%)of patients showed a complete clinical cure rate in the PF and BB groups,respectively.At week 4,the percentage of totally cured patients increased up to 95%(95%CI:89-97%)and 91%(95%CI:83-94%)in the PF and BB groups,respectively(P = NS between groups).At week 4,5%in the PF group and 9%in the BB group complained of itching.Burning and irritation after treatment applications were more common in the BB group in comparison with the PF group.The tolerability score was better in the PF group in comparison with to BB group(2.9 vs.2.2;P = 0.0001).A total of 95%of patients in the PV group had a good tolerability score(i.e.= 3)in comparison with 41%in the BB group.Conclusion:Our results show that a 3-day treatment with pyrethrins thermofobic foam is at least as effective as a 5-day treatment with benzyl benzoate lotion in convicted subjects with scabies.The foam formulation is better tolerated than the benzyl benzoate lotion.展开更多
The limited number of resins,available for stereolithography applications,is one of the key drivers in research applied to rapid prototyping.In this work an acrylic photocrosslinkable resin based on methyl methacrylat...The limited number of resins,available for stereolithography applications,is one of the key drivers in research applied to rapid prototyping.In this work an acrylic photocrosslinkable resin based on methyl methacrylate(MMA),butyl methacrylate(BMA)and poly(ethylene glycol)dimethacrylate(PEGDA)was developed with different composition and characterized in terms of mechanical,thermal and biological behaviour.Two different systems have been developed using different amount of reagent.The influence of every components have been evaluated on the final characteristic of the resin in order to optimize the final composition for applications in bone tissue engineering.The crosslinked materials showed good mechanical properties and thermal stabilities and moreover cytotoxicity test confirms good biocompatibility with no cytotoxic effect on cells metabolism.Moreover two different treatments have been proposed,using fetal bovine serum(FBS)and methanol(MeOH),in order to improve cell recognition of the surfaces.Samples threatened with MeOH allow cell adhesion and survival,promoting spreading,elongation and fusion of C2C12 muscle myoblast cells.展开更多
文摘Background:Scabies is a very common skin infection in convicts.The SIMSPE Society(SocietItaliana di Medicina e Sanit`a Penitenziaria)has organized and conducted a multicentre,randomized,comparative,parallel group,investigator-blinded trial to evaluate the efficacy and tolerability of synergized pyrethrins foam(PF)in comparison with benzyl benzoate(BB)lotion.Methods:A total of 240 convicted patients,enrolled in eight National Jail Institutions,with a clinical diagnosis of scabies,were treated with PF(n = 120)for three consecutive days or BB(n = 120)for five consecutive days.Primary study endpoints were the clinical cure rate and the local tolerability.Secondary endpoints were clinical evolution of scabietic lesions and itching intensity.Study outcomes were assessed using appropriate semiquantitative scores at baseline and after 2 and 4 weeks.A second treatment cycle was applied if after 2 weeks the patient was not judged clinically cured.Results:At week 2,a total of 75%(95 %CI:66-82%)and 71%(95%CI:62-78%)of patients showed a complete clinical cure rate in the PF and BB groups,respectively.At week 4,the percentage of totally cured patients increased up to 95%(95%CI:89-97%)and 91%(95%CI:83-94%)in the PF and BB groups,respectively(P = NS between groups).At week 4,5%in the PF group and 9%in the BB group complained of itching.Burning and irritation after treatment applications were more common in the BB group in comparison with the PF group.The tolerability score was better in the PF group in comparison with to BB group(2.9 vs.2.2;P = 0.0001).A total of 95%of patients in the PV group had a good tolerability score(i.e.= 3)in comparison with 41%in the BB group.Conclusion:Our results show that a 3-day treatment with pyrethrins thermofobic foam is at least as effective as a 5-day treatment with benzyl benzoate lotion in convicted subjects with scabies.The foam formulation is better tolerated than the benzyl benzoate lotion.
文摘The limited number of resins,available for stereolithography applications,is one of the key drivers in research applied to rapid prototyping.In this work an acrylic photocrosslinkable resin based on methyl methacrylate(MMA),butyl methacrylate(BMA)and poly(ethylene glycol)dimethacrylate(PEGDA)was developed with different composition and characterized in terms of mechanical,thermal and biological behaviour.Two different systems have been developed using different amount of reagent.The influence of every components have been evaluated on the final characteristic of the resin in order to optimize the final composition for applications in bone tissue engineering.The crosslinked materials showed good mechanical properties and thermal stabilities and moreover cytotoxicity test confirms good biocompatibility with no cytotoxic effect on cells metabolism.Moreover two different treatments have been proposed,using fetal bovine serum(FBS)and methanol(MeOH),in order to improve cell recognition of the surfaces.Samples threatened with MeOH allow cell adhesion and survival,promoting spreading,elongation and fusion of C2C12 muscle myoblast cells.
