Activation of the NOD-like receptor protein 3(NLRP3)inflammasome signaling pathway is an important mechanism underlying myocardial pyroptosis and plays an important role in inflammatory damage to myocardial tissue in ...Activation of the NOD-like receptor protein 3(NLRP3)inflammasome signaling pathway is an important mechanism underlying myocardial pyroptosis and plays an important role in inflammatory damage to myocardial tissue in patients with cardiovascular diseases(CVDs),such as diabetic cardiomyopathy,ischemia/reperfusion injury,myocardial infarction,heart failure and hypertension.Noncoding RNAs(nc RNAs)are important regulatory factors.Many Chinese medicine(CM)compounds,including their effective components,can regulate pyroptosis and exert myocardium-protecting effects.The mechanisms underlying this protection include inhibition of inflammasome protein expression,Toll-like receptor 4–NF-κB signal pathway activation,oxidative stress,endoplasmic reticulum stress(ERS),and mixed lineage kinase 3 expression and the regulation of silent information regulator 1.The NLRP3 protein is an important regulatory target for CVD prevention and treatment with CM.Exploring the effects of the interventions mediated by CM and the related mechanisms provides new ideas and perspectives for CVD prevention and treatment.展开更多
随着技术的发展,信息物理融合系统(cyber-physical system,简称CPS)在生活中扮演着越来越重要的角色,例如电力系统、铁路系统.如果CPS遭到攻击,将对现实世界的正常运转造成巨大影响,甚至威胁生命安全.垂悬指针是指向的区域被释放后未被...随着技术的发展,信息物理融合系统(cyber-physical system,简称CPS)在生活中扮演着越来越重要的角色,例如电力系统、铁路系统.如果CPS遭到攻击,将对现实世界的正常运转造成巨大影响,甚至威胁生命安全.垂悬指针是指向的区域被释放后未被置为空的指针,它是一种会导致攻击的软件缺陷.由垂悬指针导致的use-after-free和double-free漏洞能够执行任意恶意代码.迄今为止,只有少量工作针对垂悬指针进行检测、防御.其中多数都会导致过高的额外运行时开销.提出DangDone用于检测和防御垂悬指针.首先,通过静态分析检测潜在垂悬指针;然后,基于检测到的垂悬指针信息和一系列预定义的指针变换规则,依据指针传播信息变换指针,使得指针及其别名都指向同一个新引入的指针.基于该方法,实现了DangDone的原型工具.基于11个开源项目和SPEC CPU benchmark的实验结果表明:DangDone的静态分析部分只有33%的误报率,指针变换部分只引入了1%左右的额外开销.同时,DangDone成功防护了11个开源项目中的use-after-free和double-free漏洞.实验结果体现了DangDone的高效率及有效性.展开更多
基金Supported by the Scientific Research Project of Hebei Provincial Administration of Traditional Chinese Medicine (No.2020149)。
文摘Activation of the NOD-like receptor protein 3(NLRP3)inflammasome signaling pathway is an important mechanism underlying myocardial pyroptosis and plays an important role in inflammatory damage to myocardial tissue in patients with cardiovascular diseases(CVDs),such as diabetic cardiomyopathy,ischemia/reperfusion injury,myocardial infarction,heart failure and hypertension.Noncoding RNAs(nc RNAs)are important regulatory factors.Many Chinese medicine(CM)compounds,including their effective components,can regulate pyroptosis and exert myocardium-protecting effects.The mechanisms underlying this protection include inhibition of inflammasome protein expression,Toll-like receptor 4–NF-κB signal pathway activation,oxidative stress,endoplasmic reticulum stress(ERS),and mixed lineage kinase 3 expression and the regulation of silent information regulator 1.The NLRP3 protein is an important regulatory target for CVD prevention and treatment with CM.Exploring the effects of the interventions mediated by CM and the related mechanisms provides new ideas and perspectives for CVD prevention and treatment.
文摘随着技术的发展,信息物理融合系统(cyber-physical system,简称CPS)在生活中扮演着越来越重要的角色,例如电力系统、铁路系统.如果CPS遭到攻击,将对现实世界的正常运转造成巨大影响,甚至威胁生命安全.垂悬指针是指向的区域被释放后未被置为空的指针,它是一种会导致攻击的软件缺陷.由垂悬指针导致的use-after-free和double-free漏洞能够执行任意恶意代码.迄今为止,只有少量工作针对垂悬指针进行检测、防御.其中多数都会导致过高的额外运行时开销.提出DangDone用于检测和防御垂悬指针.首先,通过静态分析检测潜在垂悬指针;然后,基于检测到的垂悬指针信息和一系列预定义的指针变换规则,依据指针传播信息变换指针,使得指针及其别名都指向同一个新引入的指针.基于该方法,实现了DangDone的原型工具.基于11个开源项目和SPEC CPU benchmark的实验结果表明:DangDone的静态分析部分只有33%的误报率,指针变换部分只引入了1%左右的额外开销.同时,DangDone成功防护了11个开源项目中的use-after-free和double-free漏洞.实验结果体现了DangDone的高效率及有效性.
