吸烟和二手烟暴露严重危害人类健康,吸烟管理也是围手术期一个重要的公共卫生问题。吸烟患者术后呼吸系统、心血管系统并发症的发生率显著升高,烟草对术后疼痛控制、伤口愈合及术后康复指标均有不利影响。加速康复外科(enhanced recover...吸烟和二手烟暴露严重危害人类健康,吸烟管理也是围手术期一个重要的公共卫生问题。吸烟患者术后呼吸系统、心血管系统并发症的发生率显著升高,烟草对术后疼痛控制、伤口愈合及术后康复指标均有不利影响。加速康复外科(enhanced recovery after surgery,ERAS)提倡通过充分的循征医学证据来优化围术期处理措施,减轻患者手术的应激反应,减少术后并发症,达到快速康复的目的。本文遵从加速康复外科理念,通过检索各国文献指南证据,对围手术期戒烟策略、戒烟时间及二手烟暴露处理和戒烟方法作一综述,为临床围手术期吸烟管理提供参考。展开更多
Objective To review the current advances on the role of uncoupling protein （UCP） in the pathogenesis and progress of nonalcoholic fatty liver disease （NAFLD）.Data sources A comprehensive search of the PubMed liter...Objective To review the current advances on the role of uncoupling protein （UCP） in the pathogenesis and progress of nonalcoholic fatty liver disease （NAFLD）.Data sources A comprehensive search of the PubMed literature without restriction on the publication date was carried out using keywords such as UCP and NAFLD.Study selection Articles containing information related to NAFLD and UCP were selected and carefully analyzed.Results The typical concepts,up-to-date findings,and existing controversies of UCP2 in NAFLD were summarized.Besides,the effect of a novel subtype of UCP （hepatocellular down regulated mitochondrial carrier protein,HDMCP） in NAFLD was also analyzed.Finally,the concept that any mitochondrial inner membrane carrier protein may have,more or less,the uncoupling ability was reinforced.Conclusions Considering the importance of NAFLD in clinics and UCP in energy metabolism,we believe that this review may raise research enthusiasm on the effect of UCP in NAFLD and provide a novel mechanism and therapeutic target for NAFLD.展开更多
文摘吸烟和二手烟暴露严重危害人类健康,吸烟管理也是围手术期一个重要的公共卫生问题。吸烟患者术后呼吸系统、心血管系统并发症的发生率显著升高,烟草对术后疼痛控制、伤口愈合及术后康复指标均有不利影响。加速康复外科(enhanced recovery after surgery,ERAS)提倡通过充分的循征医学证据来优化围术期处理措施,减轻患者手术的应激反应,减少术后并发症,达到快速康复的目的。本文遵从加速康复外科理念,通过检索各国文献指南证据,对围手术期戒烟策略、戒烟时间及二手烟暴露处理和戒烟方法作一综述,为临床围手术期吸烟管理提供参考。
基金This study was supported by grants from the National Natural Science Foundation of China （No. 81000169, No. 81100277, No. 81200284, No. 81230012）, the Excellent Young Investigator Foundation of Health Bureau of Zhejiang Province （No. 2010QNA011）, the Excellent Young Investigator Natural Science Foundation of Zhejiang province （No. R2110159）, and the Project of Zhejiang Traditional Chinese Medicine Administration Bureau （No. 2010ZA065）.
文摘Objective To review the current advances on the role of uncoupling protein （UCP） in the pathogenesis and progress of nonalcoholic fatty liver disease （NAFLD）.Data sources A comprehensive search of the PubMed literature without restriction on the publication date was carried out using keywords such as UCP and NAFLD.Study selection Articles containing information related to NAFLD and UCP were selected and carefully analyzed.Results The typical concepts,up-to-date findings,and existing controversies of UCP2 in NAFLD were summarized.Besides,the effect of a novel subtype of UCP （hepatocellular down regulated mitochondrial carrier protein,HDMCP） in NAFLD was also analyzed.Finally,the concept that any mitochondrial inner membrane carrier protein may have,more or less,the uncoupling ability was reinforced.Conclusions Considering the importance of NAFLD in clinics and UCP in energy metabolism,we believe that this review may raise research enthusiasm on the effect of UCP in NAFLD and provide a novel mechanism and therapeutic target for NAFLD.
