目的系统地评价线上线下混合式教学模式与传统教学方法对“健康评估”教学效果的影响。方法检索中国知网(CNKI)、万方数据库、中国生物医学文献数据库、维普数据库、PubMed、Embase、Cochrane Library、Web of Science中所有线上线下混...目的系统地评价线上线下混合式教学模式与传统教学方法对“健康评估”教学效果的影响。方法检索中国知网(CNKI)、万方数据库、中国生物医学文献数据库、维普数据库、PubMed、Embase、Cochrane Library、Web of Science中所有线上线下混合式教学模式在“健康评估”课程中应用的随机对照研究,检索时限为建库至2023年6月15日。结果该研究共纳入17篇文献。Meta分析结果显示:线上线下混合式教学组期末成绩高于传统教学组[SMD=0.80,95%CI(0.71,0.88),P<0.001];线上线下混合式教学组自主学习能力得分高于传统教学组[SMD=0.65,95%CI(0.52,0.78),P<0.001];线上线下混合式教学组学生的满意率高于传统教学组[RR=1.28,95%CI(1.18,1.40),P<0.001]。结论线上线下混合式教学模式有助于提高学生“健康评估”课程的期末成绩,提高学生的自主学习能力和满意率,其教学效果优于传统课堂教学。展开更多
Based on the spatial distribution of ancient rocks and zircons, three ancient terranes older than ca. 2.6 Ga have recently been identified in the North China Craton, namely the Eastern, Southern, and Central Ancient T...Based on the spatial distribution of ancient rocks and zircons, three ancient terranes older than ca. 2.6 Ga have recently been identified in the North China Craton, namely the Eastern, Southern, and Central Ancient Terranes. The Eastern Ancient Terrane is the best studied and understood of the three ancient terranes. It has a long geological history back to ca. 3.8 Ga ago and includes the areas of Anshan-Benxi, eastern Hebei, eastern Shandong and western Shandong. In Anshan-Benxi, several different types of 3.8 Ga rocks were discovered together with 3.1-3.7 Ga rocks, whereas 2.9-3.0 Ga K-rich granites and 2.5 Ga syenogranite occur on larger scales. In eastern Hebei, 3.0-3.4 Ga rocks and older detrital and xenocrystic zircons were identified. In eastern Shandong, there are a large volumes of 2.7 Ga and 2.9 Ga rocks. In western Shandong, early Neoarchean （2.6-2.7 Ga） intrusive and supracrustal rocks are widely distributed. Whole-rock Nd and zircon Hf isotope data suggest that both mantle additions and crustal recycling played important roles within the Eastern Ancient Terrane during almost every tectono-magmatic event. Most BIFs in the North China Craton are late Neoarchean in age and are distributed on continental crust along the western margin of the Eastern Ancient Terrane, probably suggesting that a stable environment was one of the key factors for the formation of large-scale BIFs.展开更多
The Daqing Mountains area comprises a typical occurrence of the Khondalite Belt in the Western Block of the North China Craton (NCC). In this area, both early and late Paleoproterozoic metasedimentary rocks have been ...The Daqing Mountains area comprises a typical occurrence of the Khondalite Belt in the Western Block of the North China Craton (NCC). In this area, both early and late Paleoproterozoic metasedimentary rocks have been identified in what was originally called the Upper Wula Mountains "Subgroup". Six metasedimentary rock samples yielded SHRIMP U-Pb zircon ages of 2.56-2.04 Ga for detrital and 1.96-1.83 Ga for metamorphic zircons. Based on these data and previously published results, the following conclusions can be drawn: 1) The source region for the late Paleoproterozoic detrital sedimentary rocks is mainly 2.55 2.4 and 2.2 2.04 Ga in age, consistent with the early Precambrian geological history identified widely in the basement of the NCC. 2) The majority of sedimentary rocks of the khondalite series were deposited between 2.04 and 1.95 Ga, and then in a protracted period (1.96 and 1.83 Ga) underwent a complex history of amphibolite to granulite-facies metamorphism.展开更多
The Neoproterozoic Kangdian Rift Basin is a continental rift basin in the western Yangtze Continent.Determining its time of opening and subsequent filling pattern is an important aspect of understanding the formation ...The Neoproterozoic Kangdian Rift Basin is a continental rift basin in the western Yangtze Continent.Determining its time of opening and subsequent filling pattern is an important aspect of understanding the formation and evolution of the Yangtze Continent,South China.The Luliang Formation is the early filling in the eastern part of this rift basin,and its deposition age and filling sequence are significant for studies of the regional stratigraphic correlation,opening time,and filling pattern of this basin.Having been correlated to the upper part of the Mesoproterozoic Kunyang Group or to the Neoproterozoic Chengjiang Formation,the age and regional stratigraphic correlation of the Luliang Formation have long been uncertain.This is due to a lack of reliable absolute age constraints.To address this issue,the first zircon SHRIMP U-Pb geochronology has been established for this formation,yielding two high-precision isotopic ages of 818.6±9.2 and 805±14 Ma for the tuff layers at the bottoms of the lower and upper members of the Luliang Formation,respectively.Given the error factor,the bottom age of the lower member of the Luliang Formation can be interpreted as ca.820 Ma,corresponding to the bottom age of the lower part of the Banxi Group,which is the early filling of the Neoproterozoic Xianggui Rift Basin,a representative basin of the Neoproterozoic rift basins in the Yangtze Continent,South China.The bottom age of the upper member of the Luliang Formation can be interpreted as ca.800±5 Ma,corresponding to the bottom age of the Chengjiang Formation in the western part of the Neoproterozoic Kangdian Rift Basin and also corresponding to the bottom age of the upper part of the Banxi Group in the Neoproterozoic Xianggui Rift Basin.These ages indicate that the Neoproterozoic Kangdian Rift Basin shares the same opening time and filling sequences as those of the other Neoproterozoic rift basins in South China.Basin analysis shows that the Neoproterozoic Kangdian Rift Basin is a typical half-graben basin,with its main boundary fault in the west and basin center in the east.This basin consisted of mini unidirectional half-graben basins in its juvenile stage and simplified to become a large united half-graben basin in its mature stage,i.e.,a supradetachment basin.展开更多
OBJECTIVE:To evaluate the effects of moxibustion and acupuncture of Zusanli(ST 36)and Zhongwan(CV 12)acupoints on chronic atrophic gastritis(CAG)in rats,and to study the mechanisms behind their actions.METHODS:Forty-f...OBJECTIVE:To evaluate the effects of moxibustion and acupuncture of Zusanli(ST 36)and Zhongwan(CV 12)acupoints on chronic atrophic gastritis(CAG)in rats,and to study the mechanisms behind their actions.METHODS:Forty-four male Sprague-Dawley rats were induced with CAG by intragastric administration of 40%ethanol combined with free drinking of N-methyl-N′-nitro-N-nitrosoguanidine and irregular feeding for 12 weeks,followed by daily treatment with moxibustion or acupuncture for 2 weeks.Histopathologic examination,Western blotting of cytokines[epidermal growth factor(EGF),EGF receptor(EGFR),extracellular signal-regulated kinase(ERK),phosphorylated ERK(p-ERK)],and1 H NMR-based metabolic profiling of gastric tissues were used to measure changes related to CAG modeling and treatment.RESULTS:Moxibustion and acupuncture at Zusanli(ST 36)and Zhongwan(CV 12)each relieved CAG-induced abnormalities in histopathology and cytokine expression of ERK and p-ERK.Only moxibustion treatment regulated the expression of EGF and EGFR.Metabolites that were increased in gastric tissue by CAG induction(alanine,nicotinamide adenine dinucleotide phosphate,uracil DNA glycosylase,lactate,glycerol and adenosine)were restored to normal levels after moxibustion treatment;acupuncture treatment only normalized the levels of adenosine monophosphate and glycerol.CONCLUSION:Our findings suggest that moxibustion or acupuncture at Zusanli(ST 36)and Zhongwan(CV 12)can significantly improve the condition of CAG in rats.These treatments exert their effects on CAG through different mechanisms.展开更多
文摘目的系统地评价线上线下混合式教学模式与传统教学方法对“健康评估”教学效果的影响。方法检索中国知网(CNKI)、万方数据库、中国生物医学文献数据库、维普数据库、PubMed、Embase、Cochrane Library、Web of Science中所有线上线下混合式教学模式在“健康评估”课程中应用的随机对照研究,检索时限为建库至2023年6月15日。结果该研究共纳入17篇文献。Meta分析结果显示:线上线下混合式教学组期末成绩高于传统教学组[SMD=0.80,95%CI(0.71,0.88),P<0.001];线上线下混合式教学组自主学习能力得分高于传统教学组[SMD=0.65,95%CI(0.52,0.78),P<0.001];线上线下混合式教学组学生的满意率高于传统教学组[RR=1.28,95%CI(1.18,1.40),P<0.001]。结论线上线下混合式教学模式有助于提高学生“健康评估”课程的期末成绩,提高学生的自主学习能力和满意率,其教学效果优于传统课堂教学。
基金financially supported by the Major State Basic Research Program of the People’s Republic of China(2012CB416600)the National Natural Science Foundation of China(41472169,41172127)the Key Program of the Ministry of Land and Resources of China(DD20160121-03,12120114021301,1212010811033,and 12120115070301)
文摘Based on the spatial distribution of ancient rocks and zircons, three ancient terranes older than ca. 2.6 Ga have recently been identified in the North China Craton, namely the Eastern, Southern, and Central Ancient Terranes. The Eastern Ancient Terrane is the best studied and understood of the three ancient terranes. It has a long geological history back to ca. 3.8 Ga ago and includes the areas of Anshan-Benxi, eastern Hebei, eastern Shandong and western Shandong. In Anshan-Benxi, several different types of 3.8 Ga rocks were discovered together with 3.1-3.7 Ga rocks, whereas 2.9-3.0 Ga K-rich granites and 2.5 Ga syenogranite occur on larger scales. In eastern Hebei, 3.0-3.4 Ga rocks and older detrital and xenocrystic zircons were identified. In eastern Shandong, there are a large volumes of 2.7 Ga and 2.9 Ga rocks. In western Shandong, early Neoarchean （2.6-2.7 Ga） intrusive and supracrustal rocks are widely distributed. Whole-rock Nd and zircon Hf isotope data suggest that both mantle additions and crustal recycling played important roles within the Eastern Ancient Terrane during almost every tectono-magmatic event. Most BIFs in the North China Craton are late Neoarchean in age and are distributed on continental crust along the western margin of the Eastern Ancient Terrane, probably suggesting that a stable environment was one of the key factors for the formation of large-scale BIFs.
基金supported by National Natural Science Foundation of China (Grant No.41002062)Scientific Research Program of the Ministry of Science and Technology of China (Grant No. J0901)the Key Program of the Land and Resource Ministry of China (Grant Nos. 1212011120151,1212010811033, 1212010711815)
文摘The Daqing Mountains area comprises a typical occurrence of the Khondalite Belt in the Western Block of the North China Craton (NCC). In this area, both early and late Paleoproterozoic metasedimentary rocks have been identified in what was originally called the Upper Wula Mountains "Subgroup". Six metasedimentary rock samples yielded SHRIMP U-Pb zircon ages of 2.56-2.04 Ga for detrital and 1.96-1.83 Ga for metamorphic zircons. Based on these data and previously published results, the following conclusions can be drawn: 1) The source region for the late Paleoproterozoic detrital sedimentary rocks is mainly 2.55 2.4 and 2.2 2.04 Ga in age, consistent with the early Precambrian geological history identified widely in the basement of the NCC. 2) The majority of sedimentary rocks of the khondalite series were deposited between 2.04 and 1.95 Ga, and then in a protracted period (1.96 and 1.83 Ga) underwent a complex history of amphibolite to granulite-facies metamorphism.
基金supported by National Natural Science Foundation of China(Grant Nos.4103031541072088)China Geological Survey(Grant No.1212011121105)
文摘The Neoproterozoic Kangdian Rift Basin is a continental rift basin in the western Yangtze Continent.Determining its time of opening and subsequent filling pattern is an important aspect of understanding the formation and evolution of the Yangtze Continent,South China.The Luliang Formation is the early filling in the eastern part of this rift basin,and its deposition age and filling sequence are significant for studies of the regional stratigraphic correlation,opening time,and filling pattern of this basin.Having been correlated to the upper part of the Mesoproterozoic Kunyang Group or to the Neoproterozoic Chengjiang Formation,the age and regional stratigraphic correlation of the Luliang Formation have long been uncertain.This is due to a lack of reliable absolute age constraints.To address this issue,the first zircon SHRIMP U-Pb geochronology has been established for this formation,yielding two high-precision isotopic ages of 818.6±9.2 and 805±14 Ma for the tuff layers at the bottoms of the lower and upper members of the Luliang Formation,respectively.Given the error factor,the bottom age of the lower member of the Luliang Formation can be interpreted as ca.820 Ma,corresponding to the bottom age of the lower part of the Banxi Group,which is the early filling of the Neoproterozoic Xianggui Rift Basin,a representative basin of the Neoproterozoic rift basins in the Yangtze Continent,South China.The bottom age of the upper member of the Luliang Formation can be interpreted as ca.800±5 Ma,corresponding to the bottom age of the Chengjiang Formation in the western part of the Neoproterozoic Kangdian Rift Basin and also corresponding to the bottom age of the upper part of the Banxi Group in the Neoproterozoic Xianggui Rift Basin.These ages indicate that the Neoproterozoic Kangdian Rift Basin shares the same opening time and filling sequences as those of the other Neoproterozoic rift basins in South China.Basin analysis shows that the Neoproterozoic Kangdian Rift Basin is a typical half-graben basin,with its main boundary fault in the west and basin center in the east.This basin consisted of mini unidirectional half-graben basins in its juvenile stage and simplified to become a large united half-graben basin in its mature stage,i.e.,a supradetachment basin.
基金Supported by the National Key Basic Research Development Plan(973 Plan),China(2015CB554502)the National Natural Science Foundation of China,China(No.81574082)+1 种基金the Natural Science Foundation of Hunan Province of China,China(2018JJ2295)the Hunan Province University Innovation Platform Open Fund Project,China(No.18K066)
文摘OBJECTIVE:To evaluate the effects of moxibustion and acupuncture of Zusanli(ST 36)and Zhongwan(CV 12)acupoints on chronic atrophic gastritis(CAG)in rats,and to study the mechanisms behind their actions.METHODS:Forty-four male Sprague-Dawley rats were induced with CAG by intragastric administration of 40%ethanol combined with free drinking of N-methyl-N′-nitro-N-nitrosoguanidine and irregular feeding for 12 weeks,followed by daily treatment with moxibustion or acupuncture for 2 weeks.Histopathologic examination,Western blotting of cytokines[epidermal growth factor(EGF),EGF receptor(EGFR),extracellular signal-regulated kinase(ERK),phosphorylated ERK(p-ERK)],and1 H NMR-based metabolic profiling of gastric tissues were used to measure changes related to CAG modeling and treatment.RESULTS:Moxibustion and acupuncture at Zusanli(ST 36)and Zhongwan(CV 12)each relieved CAG-induced abnormalities in histopathology and cytokine expression of ERK and p-ERK.Only moxibustion treatment regulated the expression of EGF and EGFR.Metabolites that were increased in gastric tissue by CAG induction(alanine,nicotinamide adenine dinucleotide phosphate,uracil DNA glycosylase,lactate,glycerol and adenosine)were restored to normal levels after moxibustion treatment;acupuncture treatment only normalized the levels of adenosine monophosphate and glycerol.CONCLUSION:Our findings suggest that moxibustion or acupuncture at Zusanli(ST 36)and Zhongwan(CV 12)can significantly improve the condition of CAG in rats.These treatments exert their effects on CAG through different mechanisms.
