Objective:To evaluate the effects of Chinese medicine Dingkun Pill(定坤丹)alone or in combination with Diane-35 on patients with polycystic ovary syndrome(PCOS).Methods:This is a prospective randomized controlled tria...Objective:To evaluate the effects of Chinese medicine Dingkun Pill(定坤丹)alone or in combination with Diane-35 on patients with polycystic ovary syndrome(PCOS).Methods:This is a prospective randomized controlled trial conducted at Peking Union Medical College Hospital Beijing,China,from December 2016 to September 2017.Totally 117 PCOS patients were randomly assigned to the Dingkun Pill group(38 cases),Diane-35 group(40 cases),or combined group(39 cases).Patients in the Dingkun Pill group or Diane-35 group took daily 7 g of oral Dingkun Pill or 1 tablet of oral Diane-35,respectively,for 21 consecutive days followed by 7 drug-free days.And the combined group received a combination of Dingkun Pill and Diane-35.The treatment course was 3 months.Fasting plasma glucose and insulin,total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),triglycerides(TG),free fatty acids(FFA)and sex hormones were analyzed,quantitative insulin sensitivity check index(QUICKI)was calculated,and menstruation and acne scores were recorded at baseline and after 3-month treatment.Results:Compared with before treatment,QUICKI decreased significantly in the Dingkun Pill and combined groups after 3-month treatment(P<0.05);TC,LDL-C and FFA decreased significantly in the Dingkun Pill group(P<0.01),LDL-C also decreased obviously in the Diane-35 group(P<0.01),while TC increased significantly in the combined group(P<0.01),TG increased significantly in all groups(P<0.01);total testosterone(TT)and menstruation regularity was improved significantly in the Diane-35 and combined groups(P<0.01);acne scores were improved in all groups(P<0.01).After treatment,TC and FFA in the Dingkun Pill group were significantly lower than the Diane-35 group(P<0.05 or P<0.01);TT was lower and regular menstruation rate was higher in the Diane-35 and combined groups than the Dingkun Pill group(P<0.01),and no differences were observed between Diane-35 group and combined group(P>0.05).Conclusions:Dingkun Pill showed better effects than Diane-35 in improving insulin sensitivity,lowering TC and FFA.Diane-35 was more efficient in regulating menstruation and lowering androgen than Dingkun Pill.Combination of Dingkun Pill and Diane-35 may be a better choice to regulate menstruation,lower androgens while improve glucose metabolism in PCOS patients.(Registered on ClinicalTrials.gov,registration No.NCT03264638)。展开更多
Objective:Tocompare the clinical efficacyand safety of oral administration of BuxueYimuPills(BYP),ferrous sulfate(FS),and the combination of BYP and FS on gynecological anemia,and investigate the mechanisms using netw...Objective:Tocompare the clinical efficacyand safety of oral administration of BuxueYimuPills(BYP),ferrous sulfate(FS),and the combination of BYP and FS on gynecological anemia,and investigate the mechanisms using network pharmacology.Methods:A randomized,controlled,multi-center clinical trial was conducted.Totally 150 patients with hemoglobin of 70-110 g/L due to gynecological conditions were recruited and randomized(using the block randomization method)into Buxue Yimu Pills group(24 g/d),oral iron group(FS Tablets,0.9 g/d),and combined treatment group(BYP,24g/d plus FS Tablets,0.9 g/d),50 patients in each group.At the enrollment and 4-week treatment,complete blood count,serum iron indexes were evaluated.Adverse events,liver and renal functions,as well as blood coagulation were observed.Network pharmacology was conducted to identify the active ingredients and explore the potential mechanisms of BYP.Results:Ten(20%)and 7(14%)participants discontinued the therapy due to gastrointestinal symptoms in oral iron and combination treatment groups.All 3 groups showed elevated hemoglobin.The patients in the iron group exhibited typically elevated in serum iron and ferritin and decreased in total iron-binding capacity.No change in iron indexes was observed in BYP group.The patients in the combination treatment group neither showed significant changes in serum ferritin nortotal iron-binding capacity.No significant adverse reactions were observed in the BYP group.The network pharmacology identified 27 bioactive compounds and 145 targets of BYP on gynecological anemia.Biological processes and pathways including regulation of inflammation,hormone,angiogenesis and hemostasis,responsetodecreased oxygen levels,effects on myeloma cell,and responseto metal ions were identified.Conclusion:BYP contributes to the practical improvement on gynecological anemia potentially through multi-target mechanisms and optimized iron re-distribution.展开更多
Diminished ovarian reserve(DOR),generally defined as a decreased number or quality of oocytes,has a significant impact on quality of life and fertility in women.In recent years,the incidence of DOR has been increasing...Diminished ovarian reserve(DOR),generally defined as a decreased number or quality of oocytes,has a significant impact on quality of life and fertility in women.In recent years,the incidence of DOR has been increasing and the ages of patients are younger.The search for an effective DOR treatment has emerged as one of the preeminent research topics in reproductive health.An effective DOR therapy would improve ovarian function,fertility,and quality of life in patients.In this review we evaluated DOR treatment progress both in Western medicine and Chinese medicine,and elucidated the characteristics of each treatment.展开更多
文摘Objective:To evaluate the effects of Chinese medicine Dingkun Pill(定坤丹)alone or in combination with Diane-35 on patients with polycystic ovary syndrome(PCOS).Methods:This is a prospective randomized controlled trial conducted at Peking Union Medical College Hospital Beijing,China,from December 2016 to September 2017.Totally 117 PCOS patients were randomly assigned to the Dingkun Pill group(38 cases),Diane-35 group(40 cases),or combined group(39 cases).Patients in the Dingkun Pill group or Diane-35 group took daily 7 g of oral Dingkun Pill or 1 tablet of oral Diane-35,respectively,for 21 consecutive days followed by 7 drug-free days.And the combined group received a combination of Dingkun Pill and Diane-35.The treatment course was 3 months.Fasting plasma glucose and insulin,total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),triglycerides(TG),free fatty acids(FFA)and sex hormones were analyzed,quantitative insulin sensitivity check index(QUICKI)was calculated,and menstruation and acne scores were recorded at baseline and after 3-month treatment.Results:Compared with before treatment,QUICKI decreased significantly in the Dingkun Pill and combined groups after 3-month treatment(P<0.05);TC,LDL-C and FFA decreased significantly in the Dingkun Pill group(P<0.01),LDL-C also decreased obviously in the Diane-35 group(P<0.01),while TC increased significantly in the combined group(P<0.01),TG increased significantly in all groups(P<0.01);total testosterone(TT)and menstruation regularity was improved significantly in the Diane-35 and combined groups(P<0.01);acne scores were improved in all groups(P<0.01).After treatment,TC and FFA in the Dingkun Pill group were significantly lower than the Diane-35 group(P<0.05 or P<0.01);TT was lower and regular menstruation rate was higher in the Diane-35 and combined groups than the Dingkun Pill group(P<0.01),and no differences were observed between Diane-35 group and combined group(P>0.05).Conclusions:Dingkun Pill showed better effects than Diane-35 in improving insulin sensitivity,lowering TC and FFA.Diane-35 was more efficient in regulating menstruation and lowering androgen than Dingkun Pill.Combination of Dingkun Pill and Diane-35 may be a better choice to regulate menstruation,lower androgens while improve glucose metabolism in PCOS patients.(Registered on ClinicalTrials.gov,registration No.NCT03264638)。
文摘Objective:Tocompare the clinical efficacyand safety of oral administration of BuxueYimuPills(BYP),ferrous sulfate(FS),and the combination of BYP and FS on gynecological anemia,and investigate the mechanisms using network pharmacology.Methods:A randomized,controlled,multi-center clinical trial was conducted.Totally 150 patients with hemoglobin of 70-110 g/L due to gynecological conditions were recruited and randomized(using the block randomization method)into Buxue Yimu Pills group(24 g/d),oral iron group(FS Tablets,0.9 g/d),and combined treatment group(BYP,24g/d plus FS Tablets,0.9 g/d),50 patients in each group.At the enrollment and 4-week treatment,complete blood count,serum iron indexes were evaluated.Adverse events,liver and renal functions,as well as blood coagulation were observed.Network pharmacology was conducted to identify the active ingredients and explore the potential mechanisms of BYP.Results:Ten(20%)and 7(14%)participants discontinued the therapy due to gastrointestinal symptoms in oral iron and combination treatment groups.All 3 groups showed elevated hemoglobin.The patients in the iron group exhibited typically elevated in serum iron and ferritin and decreased in total iron-binding capacity.No change in iron indexes was observed in BYP group.The patients in the combination treatment group neither showed significant changes in serum ferritin nortotal iron-binding capacity.No significant adverse reactions were observed in the BYP group.The network pharmacology identified 27 bioactive compounds and 145 targets of BYP on gynecological anemia.Biological processes and pathways including regulation of inflammation,hormone,angiogenesis and hemostasis,responsetodecreased oxygen levels,effects on myeloma cell,and responseto metal ions were identified.Conclusion:BYP contributes to the practical improvement on gynecological anemia potentially through multi-target mechanisms and optimized iron re-distribution.
基金Supported by the Fund for Beijing Science&Technology Development of Traditional Chinese Medicine(No.JJ-2018-73)。
文摘Diminished ovarian reserve(DOR),generally defined as a decreased number or quality of oocytes,has a significant impact on quality of life and fertility in women.In recent years,the incidence of DOR has been increasing and the ages of patients are younger.The search for an effective DOR treatment has emerged as one of the preeminent research topics in reproductive health.An effective DOR therapy would improve ovarian function,fertility,and quality of life in patients.In this review we evaluated DOR treatment progress both in Western medicine and Chinese medicine,and elucidated the characteristics of each treatment.
