目的:对医源性皮肤损伤研究热点及趋势进行可视化分析。方法:计算机检索Web of Science和中国知网(CNKI)建库至2022年10月25日有关医源性皮肤损伤的文献。采用CiteSpace、VOSviewer软件以及Excel对检索结果进行分析。结果:共纳入医源性...目的:对医源性皮肤损伤研究热点及趋势进行可视化分析。方法:计算机检索Web of Science和中国知网(CNKI)建库至2022年10月25日有关医源性皮肤损伤的文献。采用CiteSpace、VOSviewer软件以及Excel对检索结果进行分析。结果:共纳入医源性皮肤损伤相关文献1211篇,其中中文文献211篇,英文文献1000篇。英文文献中,美国发文量最多,其次是中国。国外隆德大学研究机构(Lund Univ)最为活跃,国内青岛大学附属医院研究机构最为活跃,医源性皮肤损伤已形成核心学术团队,作者以同一机构内合作为主,未来应加强儿科、皮肤科、肿瘤科、重症监护室及老年科等科室合作,形成系统化的皮肤损伤预防管理体制。结论:通过CiteSpace软件直观展现国内外医源性皮肤损伤的研究热点,为研究者提供新的视角,推动该领域研究多元化。展开更多
β-Amyloid（Afl） plaques and intracellular neurofibrillary lesions in the brain are markers of Alzheimer＇s disease（AD）. The ability to safely decrease Aft concentrations is potentially important as a preventive st...β-Amyloid（Afl） plaques and intracellular neurofibrillary lesions in the brain are markers of Alzheimer＇s disease（AD）. The ability to safely decrease Aft concentrations is potentially important as a preventive strategy for AD. The interactions between vanillin and Aft polypeptide were investigated via fluorescence spectroscopy and atomic force microscopy（AFM）. The results of fluorescence and synchronous spectroscopies illustrate that the intrinsic fluorescence of tyrosine（Tyr） residues in Aβ1-42 aggregates can be quenched strongly upon the formation of vanil- lin-Aβ-42 complex. Thioflavine T（ThT）-induced fluorescence changes indicated that Aβ1--42 aggregates could be disaggregated by vanillin, and the AFM images of Aβ1-42 enunciated the depolymerization of Aβ1-42 aggregates by vanillin in a dose-dependent manner. Vanillin may be a potential pharmacological agent for the treatment of AD.展开更多
文摘目的:对医源性皮肤损伤研究热点及趋势进行可视化分析。方法:计算机检索Web of Science和中国知网(CNKI)建库至2022年10月25日有关医源性皮肤损伤的文献。采用CiteSpace、VOSviewer软件以及Excel对检索结果进行分析。结果:共纳入医源性皮肤损伤相关文献1211篇,其中中文文献211篇,英文文献1000篇。英文文献中,美国发文量最多,其次是中国。国外隆德大学研究机构(Lund Univ)最为活跃,国内青岛大学附属医院研究机构最为活跃,医源性皮肤损伤已形成核心学术团队,作者以同一机构内合作为主,未来应加强儿科、皮肤科、肿瘤科、重症监护室及老年科等科室合作,形成系统化的皮肤损伤预防管理体制。结论:通过CiteSpace软件直观展现国内外医源性皮肤损伤的研究热点,为研究者提供新的视角,推动该领域研究多元化。
基金Supported by the National Natural Science Foundation of China（Nos.21205076, 21175086）, the Postdoctoral Science Foundation of China（No.2013M541203） and the Hundred-Talent Project of Shanxi Province, China.
文摘β-Amyloid（Afl） plaques and intracellular neurofibrillary lesions in the brain are markers of Alzheimer＇s disease（AD）. The ability to safely decrease Aft concentrations is potentially important as a preventive strategy for AD. The interactions between vanillin and Aft polypeptide were investigated via fluorescence spectroscopy and atomic force microscopy（AFM）. The results of fluorescence and synchronous spectroscopies illustrate that the intrinsic fluorescence of tyrosine（Tyr） residues in Aβ1-42 aggregates can be quenched strongly upon the formation of vanil- lin-Aβ-42 complex. Thioflavine T（ThT）-induced fluorescence changes indicated that Aβ1--42 aggregates could be disaggregated by vanillin, and the AFM images of Aβ1-42 enunciated the depolymerization of Aβ1-42 aggregates by vanillin in a dose-dependent manner. Vanillin may be a potential pharmacological agent for the treatment of AD.
