背景与目的:淋巴瘤与转移性淋巴结均可表现为体积增大,实时剪切波弹性成像(shear wave elastography,SWE)能获得组织内部的弹性分布的定量信息,以不同色彩反映组织的软硬度。该研究旨在探讨SWE在鉴别淋巴瘤与转移性淋巴结中的应用价值...背景与目的:淋巴瘤与转移性淋巴结均可表现为体积增大,实时剪切波弹性成像(shear wave elastography,SWE)能获得组织内部的弹性分布的定量信息,以不同色彩反映组织的软硬度。该研究旨在探讨SWE在鉴别淋巴瘤与转移性淋巴结中的应用价值。方法:采用回顾性、总结的研究方法,选取2016年4月—2017年3月在北京大学首钢医院诊治的疑似淋巴瘤与转移性淋巴结的颈部恶性淋巴结肿大的80例患者作为研究对象,所有患者都给予常规超声与SWE诊断,记录诊断参数与鉴别诊断价值。结果:在80例患者中,病理诊断为转移性淋巴结的患者40例(转移组),恶性淋巴瘤患者40例(淋巴瘤组)。淋巴瘤组的淋巴结直径显著长于转移组(P<0.05),两组长短径比值对比差异无统计学意义(P>0.05)。转移组淋巴结的弹性模量平均值与最大值显著高于淋巴瘤组(P<0.05)。以弹性模量平均值15.80 k Pa为诊断界值时,灵敏度为95.3%,特异度为81.3%;以弹性模量最大值38.35 k Pa为诊断界值时,灵敏度为85.0%,特异度为98.8%。受试者工作特征(receiver operating characteristic,ROC)曲线分析结果显示,应用淋巴结弹性模量平均值和最大值鉴别转移性淋巴结和淋巴瘤淋巴结的曲线下面积(area under curve,AUC)分别为0.945和0.952。结论:SWE在鉴别诊断转移性淋巴结与淋巴瘤的准确性较高,可给临床医师提供客观、直观的硬度信息,具有重要的临床诊断价值。展开更多
The structure and excited state properties of the H- and J-aggregates of the marine carbonyl carotenoid, fucoxanthin(Fx), were studied by various spectroscopic methods, and compared with those of Fx monomers in polar ...The structure and excited state properties of the H- and J-aggregates of the marine carbonyl carotenoid, fucoxanthin(Fx), were studied by various spectroscopic methods, and compared with those of Fx monomers in polar organic solvents. The fluorescent analysis indicated tliat the higher vibronic states of S2 contribute more to populating the S1 state, from which fluorescent emission mainly originates. Resonance Raman and density functional theory calculations confirmed the ‘card-packed' and chead-to-taiF structures of the H- and J-aggregates of Fx, respectively. An fs time-resolved absorption study proved the coexistence of Si and intramolecular charge transfer relaxation pathways upon excitation to the S2 state for both tlie monomers and aggregates.展开更多
文摘背景与目的:淋巴瘤与转移性淋巴结均可表现为体积增大,实时剪切波弹性成像(shear wave elastography,SWE)能获得组织内部的弹性分布的定量信息,以不同色彩反映组织的软硬度。该研究旨在探讨SWE在鉴别淋巴瘤与转移性淋巴结中的应用价值。方法:采用回顾性、总结的研究方法,选取2016年4月—2017年3月在北京大学首钢医院诊治的疑似淋巴瘤与转移性淋巴结的颈部恶性淋巴结肿大的80例患者作为研究对象,所有患者都给予常规超声与SWE诊断,记录诊断参数与鉴别诊断价值。结果:在80例患者中,病理诊断为转移性淋巴结的患者40例(转移组),恶性淋巴瘤患者40例(淋巴瘤组)。淋巴瘤组的淋巴结直径显著长于转移组(P<0.05),两组长短径比值对比差异无统计学意义(P>0.05)。转移组淋巴结的弹性模量平均值与最大值显著高于淋巴瘤组(P<0.05)。以弹性模量平均值15.80 k Pa为诊断界值时,灵敏度为95.3%,特异度为81.3%;以弹性模量最大值38.35 k Pa为诊断界值时,灵敏度为85.0%,特异度为98.8%。受试者工作特征(receiver operating characteristic,ROC)曲线分析结果显示,应用淋巴结弹性模量平均值和最大值鉴别转移性淋巴结和淋巴瘤淋巴结的曲线下面积(area under curve,AUC)分别为0.945和0.952。结论:SWE在鉴别诊断转移性淋巴结与淋巴瘤的准确性较高,可给临床医师提供客观、直观的硬度信息,具有重要的临床诊断价值。
基金Supported by the National Natural Science Foundation of China(Nos.21273282,21673289,21673288,21173265)the International Cooperation Project Between China and Russia(NSFC-RFBR)(No.21411130185).
文摘The structure and excited state properties of the H- and J-aggregates of the marine carbonyl carotenoid, fucoxanthin(Fx), were studied by various spectroscopic methods, and compared with those of Fx monomers in polar organic solvents. The fluorescent analysis indicated tliat the higher vibronic states of S2 contribute more to populating the S1 state, from which fluorescent emission mainly originates. Resonance Raman and density functional theory calculations confirmed the ‘card-packed' and chead-to-taiF structures of the H- and J-aggregates of Fx, respectively. An fs time-resolved absorption study proved the coexistence of Si and intramolecular charge transfer relaxation pathways upon excitation to the S2 state for both tlie monomers and aggregates.
