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益脉康胶囊联合康柏西普治疗视网膜静脉阻塞的临床研究 被引量:2
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作者 马宁 左志高 +2 位作者 买志彬 晁炜静 赵泽 《现代药物与临床》 CAS 2021年第8期1604-1607,共4页
目的探讨益脉康胶囊联合康柏西普眼用注射液治疗视网膜静脉阻塞的临床疗效。方法选取2019年8月—2020年12月在中国人民武装警察部队河南省总队医院眼科就诊的106例视网膜静脉阻塞患者作为研究对象,所有患者按随机数字表法分为对照组和... 目的探讨益脉康胶囊联合康柏西普眼用注射液治疗视网膜静脉阻塞的临床疗效。方法选取2019年8月—2020年12月在中国人民武装警察部队河南省总队医院眼科就诊的106例视网膜静脉阻塞患者作为研究对象,所有患者按随机数字表法分为对照组和治疗组,每组各53例。对照组采用无菌针管将康柏西普眼用注射液注入角膜缘后4mm睫状体平坦部位,0.05 mL/次,1次/月,共治疗3次。治疗组在对照组基础上口服益脉康胶囊,0.6 g/次,3次/d。两组在治疗3个月统计疗效。观察两组的临床疗效,评估两组患者治疗前后黄斑中心凹厚度、最佳矫正视力值(BCVA)。检测患者的血清白细胞介素-6(IL-6)、巨噬细胞炎性蛋白-1(MIP-1)、超敏C-反应蛋白(hs-CRP)水平。结果治疗后,治疗组患者的总有效率为94.34%,对照组的总有效率为81.13%,组间有明显差异(P<0.05)。治疗后,两组的黄斑中心凹厚度显著降低,BCVA明显升高(P<0.05);治疗组的黄斑中心凹厚度比对照组低(P<0.05),BCVA比对照组高。治疗后,两组的IL-6、MIP-1、hs-CRP水平显著降低(P<0.05),治疗组IL-6、MIP-1、hs-CRP水平降低比对照组明显(P<0.05)。结论益脉康胶囊联合康柏西普眼用注射液治疗视网膜静脉阻塞具有较好的临床疗效,可提高视力,减轻炎症反应,不增加不良反应。 展开更多
关键词 益脉康胶囊 康柏西普眼用注射液 视网膜静脉阻塞 视力 炎症因子
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Contrast sensitivity and higher-order aberrations in patients with astigmatism 被引量:16
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作者 ZHENG Guang-ying DU Jun +7 位作者 ZHANG Jin-song LIU Su-bing NIE Xiao-li ZHU Xiao-hong TANG Xiu-xia XIN Bao-li mai zhi-bin ZHANG Wei-xia 《Chinese Medical Journal》 SCIE CAS CSCD 2007年第10期882-885,共4页
Background Astigmatism is one of the most significant obstacles for achieving satisfactory visual function. This study was to evaluate the influence of astigmatism on contrast sensitivity (CS) and higher-order aberr... Background Astigmatism is one of the most significant obstacles for achieving satisfactory visual function. This study was to evaluate the influence of astigmatism on contrast sensitivity (CS) and higher-order aberrations. Methods CS, accommodation response and wavefront aberration were measured in 113 patients with astigmatism, aged 18-36 years. Both single and binocular visual performance were examined under four lighting conditions: photopia, photopia with glare, scotopia and scotopia with glare respectively. Accommodation response was classified as normal, abnormal and low. The contribution of the power and axis of astigmatism to CS, accommodation response and wavefront aberration was analyzed. Results As the dioptric power of astigmatism increased, the loss of CS spatial frequency changed from high to intermediate, and then to low frequency. CS scores varied at different illuminance levels, descending in the following sequence: photopia, photopia with glare, scotopia, and scotopia with glare. However, the normal accommodation group showed better CS values under photopia with glare than without glare. The range of influenced direction of sine-wave gratings remained mostly at the meridian line of high dioptric power, which would be expanded when optical accommadation attenuated. The patients with symmetrical astigmatism got higher CS scores with binoculus vision than with dominant eye vision, while the patients with asymmetrical astigmatism did this only at scotopia with glare. Among higher-order aberrations, coma aberration, secondary coma aberration and the total higher order aberration were influenced by astigmatism, all of which rising with the power of astigmatism increased. Conclusions Reducing astigmatism might improve the performance of visual function. Not only the power of astigmatism should be cut down, but also the binocular axes should be made symmetrically. 展开更多
关键词 ASTIGMATISM contrast sensitivity higher order aberration
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