目的探讨大脑中央核心区(cerebral central core,CCC)高血压性脑出血的分型方法及其对选择手术入路的指导意义,并分析内镜手术疗效。方法回顾性分析54例CCC高血压性脑出血病人的临床资料,分为外侧型(n=32)、内侧型(n=18)和混合型(n=4)...目的探讨大脑中央核心区(cerebral central core,CCC)高血压性脑出血的分型方法及其对选择手术入路的指导意义,并分析内镜手术疗效。方法回顾性分析54例CCC高血压性脑出血病人的临床资料,分为外侧型(n=32)、内侧型(n=18)和混合型(n=4)。外侧型病人采用经外侧裂-岛叶入路内镜手术,内侧型病人采用经Kocher点-侧脑室额角入路内镜手术,混合型病人采用经Kocher点外侧额中回皮质造瘘入路。结果术后24 h复查头部CT显示脑实质血肿完全和近全清除52例(96.3%),大部分清除2例(3.7%);脑脊液循环通路恢复率94.4%。术后2周GCS评分较术前明显提高(P <0.05)。随访12~60个月,无死亡病例,无新发脑积水病人。结论对CCC高血压性脑出血,神经内镜手术是一种微侵袭而有效的方法,术前根据血肿影像学特点进行分型有利于选择合适的手术入路。展开更多
习近平总书记在全国高校思想政治工作会议上指出,高校各类课程与思政课程要同向同行育人。计算机辅助药物设计(Computer-aided drug design,CADD)作为药学专业课,同时也是多学科交叉的前沿领域,其课程思政教学研究必须紧步推进。文章结...习近平总书记在全国高校思想政治工作会议上指出,高校各类课程与思政课程要同向同行育人。计算机辅助药物设计(Computer-aided drug design,CADD)作为药学专业课,同时也是多学科交叉的前沿领域,其课程思政教学研究必须紧步推进。文章结合CADD课程教学的现状,论述了在CADD课程教学中引入思政教育的必要性和可行性,并对CADD课程教学中思政元素的挖掘进行了研究探索,有效帮助学生在掌握专业知识的同时提升综合素质,有助于为我国医药领域培育更多有理想、有道德、有文化、有纪律的青年力量。展开更多
DNA double-strand breaks are repaired through either non-homologous end joining(NHEJ) or homologous recombination repair(HRR) pathway.The well-characterized regulatory mechanisms of double-strand break repair(DSBR) ar...DNA double-strand breaks are repaired through either non-homologous end joining(NHEJ) or homologous recombination repair(HRR) pathway.The well-characterized regulatory mechanisms of double-strand break repair(DSBR) are mainly found at the level of complicated repair protein interactions and modifications.Regulation of DSBR at the transcriptional level was also reported.In this study,we found that DSBR can be regulated by miR-34a at the post-transcriptional level.Specifically,miR-34a,which can be activated by DNA damages,represses DSBR activities by impairing both NHEJ and HRR pathways in cultured cells.The repression is mainly through targeting the critical DSBR promoting factor SIRT1,as ectopically expressed SIRT1 without 3'-UTR can rescue the inhibitory roles of miR-34a on DSBR.Further studies demonstrate that SIRT1 conversely represses miR-34a expression.Taken together,our data show that miR-34a is a new repressor of DSBR and the mutual inhibition between miR-34a and SIRT1 may contribute to regulation of DNA damage repair.展开更多
文摘目的探讨大脑中央核心区(cerebral central core,CCC)高血压性脑出血的分型方法及其对选择手术入路的指导意义,并分析内镜手术疗效。方法回顾性分析54例CCC高血压性脑出血病人的临床资料,分为外侧型(n=32)、内侧型(n=18)和混合型(n=4)。外侧型病人采用经外侧裂-岛叶入路内镜手术,内侧型病人采用经Kocher点-侧脑室额角入路内镜手术,混合型病人采用经Kocher点外侧额中回皮质造瘘入路。结果术后24 h复查头部CT显示脑实质血肿完全和近全清除52例(96.3%),大部分清除2例(3.7%);脑脊液循环通路恢复率94.4%。术后2周GCS评分较术前明显提高(P <0.05)。随访12~60个月,无死亡病例,无新发脑积水病人。结论对CCC高血压性脑出血,神经内镜手术是一种微侵袭而有效的方法,术前根据血肿影像学特点进行分型有利于选择合适的手术入路。
文摘习近平总书记在全国高校思想政治工作会议上指出,高校各类课程与思政课程要同向同行育人。计算机辅助药物设计(Computer-aided drug design,CADD)作为药学专业课,同时也是多学科交叉的前沿领域,其课程思政教学研究必须紧步推进。文章结合CADD课程教学的现状,论述了在CADD课程教学中引入思政教育的必要性和可行性,并对CADD课程教学中思政元素的挖掘进行了研究探索,有效帮助学生在掌握专业知识的同时提升综合素质,有助于为我国医药领域培育更多有理想、有道德、有文化、有纪律的青年力量。
基金supported by the National Basic Research Program of China (2011CB965203)the National Natural Science Foundation of China (31030026 and 31021091)
文摘DNA double-strand breaks are repaired through either non-homologous end joining(NHEJ) or homologous recombination repair(HRR) pathway.The well-characterized regulatory mechanisms of double-strand break repair(DSBR) are mainly found at the level of complicated repair protein interactions and modifications.Regulation of DSBR at the transcriptional level was also reported.In this study,we found that DSBR can be regulated by miR-34a at the post-transcriptional level.Specifically,miR-34a,which can be activated by DNA damages,represses DSBR activities by impairing both NHEJ and HRR pathways in cultured cells.The repression is mainly through targeting the critical DSBR promoting factor SIRT1,as ectopically expressed SIRT1 without 3'-UTR can rescue the inhibitory roles of miR-34a on DSBR.Further studies demonstrate that SIRT1 conversely represses miR-34a expression.Taken together,our data show that miR-34a is a new repressor of DSBR and the mutual inhibition between miR-34a and SIRT1 may contribute to regulation of DNA damage repair.
