Objective: To follow up the participants of the randomized clinical trial "Efficacy and Safety of Niaoduqing Particles(尿毒清颗粒) for Delaying Moderate-to-Severe Renal Dysfunction", and assess the long-term...Objective: To follow up the participants of the randomized clinical trial "Efficacy and Safety of Niaoduqing Particles(尿毒清颗粒) for Delaying Moderate-to-Severe Renal Dysfunction", and assess the long-term effects of Niaoduqing Particles on delaying the progression of renal dysfunction. Methods: Participants, who had previously been randomly assigned to receive Niaoduqing Particles or placebo for 24 weeks(146 cases in each group), were invited to follow-up and all were administered Niaoduqing Particles 5 g thrice daily and 10 g before bedtime for 24 weeks. The primary endpoints were changes in baseline serum creatinine(Scr) and estimated glomerular filtration rate(e GFR) after completion of the open-label treatment period. Results: After the double-blind period, the median(interquartile range) changes in Scr were 1.1(–13.0–24.1) and 11.7(–2.6–42.9) μmol/L for the Niaoduqing Particle and placebo groups, respectively(P=0.008), and the median changes in e GFRs were –0.2(–4.3–2.7) and –2.21(–5.7–0.8) mL·min^(-1)·1.73 m^(-2), respectively(P=0.016). There were significant differences in the double-blind period changes in renal function between groups. After the open-label period, the median changes in Scr were 9.0(–10.0–41.9) and 17.5(–6.0–50.0) μmol/L for the Niaoduqing Particle and placebo groups according to baseline grouping, respectively(P=0.214), and the median changes in eGFRs were –2.3(–6.4–1.9) and –3.7(–7.5–1.1) mL·min^(-1)·1.73 m^(-2), respectively(P=0.134). There were no statistical differences in the open-label period changes in renal function between groups. The eGFR reduction of participants who accepted Niaoduqing Particle treatment for 48 weeks was projected to 2.5 m L·min^(-1)·1.73 m(-2) per year. Conclusions: Niaoduqing Particles appear to have long-term efficacy for patients with moderate-to-severe renal dysfunction. Although there was no statistical difference, the early use of Niaoduqing Paticles seems to ameliorate the worsening of renal function.展开更多
Objective： To observe the specificity of reinforcing and reducing methods of mild moxibustion and explore its clinical significance. Methods： Thirty healthy students were selected and given reinforcing of mild moxi...Objective： To observe the specificity of reinforcing and reducing methods of mild moxibustion and explore its clinical significance. Methods： Thirty healthy students were selected and given reinforcing of mild moxibustion on the left Neiguan （PC 6） and reducing on the right Neiguan （PC 6） respectively. Temperature of the acupoint skin surface and the temperature-time curve were recorded by a digital thermometer. Results： In application of mild moxibustion on Neiguan （PC 6）, there was a statistical difference in the temperature-increase section between reinforcing and reducing methods （P〈0.01）. The temperature-increasing section of the temperature-time curve in the reducing method was obviously steeper than that in the reinforcing method. In the period of 0.5-3 min during moxibustion, the temperature of Neiguan （PC 6） was remarkably higher in the reducing than in the reinforcing （P〈0.01）. In the application of the reducing, the time for the temperature of Neiguan （PC 6） to increase to 40~C was remarkably advanced （P〈0.05） and the rate of burning pain in the subjects was remarkably higher in the reducing method than in the reinforcing method （P〈0.001）. Conclusion： In comparison with the reinforcing method, the acupoint temperature increased more quickly in the application of reducing method and can produce obvious hot stimulation in a short period of time. In the application of the reinforcing method, the acupoint temperature increased mildly and could enhance the tolerance of the organism to the high temperature.展开更多
基金Supported by the National Key Technology R&D Program(No.2015BAI12B06)Key Program of National Natural Science Foundation of China(No.81330019)+1 种基金General Program of National Natural Science Foundation of China(No.81670671)the Beijing Science and Technology Project(No.D171100002817002,D181100000118002,and D181100000118004)
文摘Objective: To follow up the participants of the randomized clinical trial "Efficacy and Safety of Niaoduqing Particles(尿毒清颗粒) for Delaying Moderate-to-Severe Renal Dysfunction", and assess the long-term effects of Niaoduqing Particles on delaying the progression of renal dysfunction. Methods: Participants, who had previously been randomly assigned to receive Niaoduqing Particles or placebo for 24 weeks(146 cases in each group), were invited to follow-up and all were administered Niaoduqing Particles 5 g thrice daily and 10 g before bedtime for 24 weeks. The primary endpoints were changes in baseline serum creatinine(Scr) and estimated glomerular filtration rate(e GFR) after completion of the open-label treatment period. Results: After the double-blind period, the median(interquartile range) changes in Scr were 1.1(–13.0–24.1) and 11.7(–2.6–42.9) μmol/L for the Niaoduqing Particle and placebo groups, respectively(P=0.008), and the median changes in e GFRs were –0.2(–4.3–2.7) and –2.21(–5.7–0.8) mL·min^(-1)·1.73 m^(-2), respectively(P=0.016). There were significant differences in the double-blind period changes in renal function between groups. After the open-label period, the median changes in Scr were 9.0(–10.0–41.9) and 17.5(–6.0–50.0) μmol/L for the Niaoduqing Particle and placebo groups according to baseline grouping, respectively(P=0.214), and the median changes in eGFRs were –2.3(–6.4–1.9) and –3.7(–7.5–1.1) mL·min^(-1)·1.73 m^(-2), respectively(P=0.134). There were no statistical differences in the open-label period changes in renal function between groups. The eGFR reduction of participants who accepted Niaoduqing Particle treatment for 48 weeks was projected to 2.5 m L·min^(-1)·1.73 m(-2) per year. Conclusions: Niaoduqing Particles appear to have long-term efficacy for patients with moderate-to-severe renal dysfunction. Although there was no statistical difference, the early use of Niaoduqing Paticles seems to ameliorate the worsening of renal function.
基金supported by National Basic Research Program of China(973 Program,2009CB522901)National Natural Science Foundation of China(81202648)+2 种基金Project of Shanghai Science and Technology Committee(11DZ1973300,11ZR1436700)Innovation Project of Shanghai Municipal Education Commission(11YZ68)Leading Academic Discipline Project of the State Administration of Traditional Chinese Medicine
文摘Objective： To observe the specificity of reinforcing and reducing methods of mild moxibustion and explore its clinical significance. Methods： Thirty healthy students were selected and given reinforcing of mild moxibustion on the left Neiguan （PC 6） and reducing on the right Neiguan （PC 6） respectively. Temperature of the acupoint skin surface and the temperature-time curve were recorded by a digital thermometer. Results： In application of mild moxibustion on Neiguan （PC 6）, there was a statistical difference in the temperature-increase section between reinforcing and reducing methods （P〈0.01）. The temperature-increasing section of the temperature-time curve in the reducing method was obviously steeper than that in the reinforcing method. In the period of 0.5-3 min during moxibustion, the temperature of Neiguan （PC 6） was remarkably higher in the reducing than in the reinforcing （P〈0.01）. In the application of the reducing, the time for the temperature of Neiguan （PC 6） to increase to 40~C was remarkably advanced （P〈0.05） and the rate of burning pain in the subjects was remarkably higher in the reducing method than in the reinforcing method （P〈0.001）. Conclusion： In comparison with the reinforcing method, the acupoint temperature increased more quickly in the application of reducing method and can produce obvious hot stimulation in a short period of time. In the application of the reinforcing method, the acupoint temperature increased mildly and could enhance the tolerance of the organism to the high temperature.
