Type 2 diabetes mellitus(T2DM)is recognized as a heterogeneous and complicated disease that is able to influence individuals at various life stages[1].Apart from traditional predictors such as age,family history of di...Type 2 diabetes mellitus(T2DM)is recognized as a heterogeneous and complicated disease that is able to influence individuals at various life stages[1].Apart from traditional predictors such as age,family history of diabetes,body mass index,and so on,ambient air pollution is also shown to increase the risk of T2DM in previous studies.展开更多
Lead exposure is a known potential risk factor for neurodegenerative diseases such as Alzheimer’s disease (AD). Exposure to lead during the critical phase of brain development has been linked with mental retardatio...Lead exposure is a known potential risk factor for neurodegenerative diseases such as Alzheimer’s disease (AD). Exposure to lead during the critical phase of brain development has been linked with mental retardation and hypophrenia in later life.展开更多
Objective To our knowledge, no definitive conclusion has been reached regarding the relationship between glucocorticoids and hypertension. Here, we aimed to explore the characteristics of glucocorticoids in participan...Objective To our knowledge, no definitive conclusion has been reached regarding the relationship between glucocorticoids and hypertension. Here, we aimed to explore the characteristics of glucocorticoids in participants with dysglycemia and hypertension, and to analyze their association with blood pressure indicators.Methods The participants of this study were from the Henan Rural Cohort study. A total of 1,688 patients 18–79 years of age were included in the matched case control study after application of the inclusion and exclusion criteria. Statistical methods were used to analyze the association between glucocorticoids and various indices of blood pressure, through approaches such as logistic regression analysis, trend tests, linear regression, and restricted cubic regression.Results The study population consisted of 552 patients with dysglycemia and hypertension(32.7%).The patients with co-morbidities had higher levels of serum cortisol(P = 0.009) and deoxycortisol(P <0.001). The adjusted odds ratios(and 95% confidence intervals) for dysglycemia with hypertension were1.55(1.18, 2.04) for the highest tertile of Ln-cortisol compared with the lowest tertile. Additionally, the highest Ln-deoxycortisol levels were associated with increased prevalence of dysglycemia with hypertension by 159%(95% confidence interval: 122%, 207%).Conclusions Serum deoxycortisol was positively correlated with systolic blood pressure, pulse pressure, mean arterial pressure, mean blood pressure, and mean proportional arterial pressure.Glucocorticoids(deoxycortisol and cortisol) increase the risk of hypertension in people with dysglycemia, particularly in those with T2 DM.展开更多
Metabolic syndrome(MetS),a cluster of modifiable metabolic conditions(including abdominal obesity,dyslipidemia,elevated blood pressure,and hyperglycemia),has become an essential contributor to the global health burden...Metabolic syndrome(MetS),a cluster of modifiable metabolic conditions(including abdominal obesity,dyslipidemia,elevated blood pressure,and hyperglycemia),has become an essential contributor to the global health burden and public health challenges worldwide.展开更多
基金supported by the Science and Technology Innovation Team Support Plan of Colleges and Universities in Henan Province[Grant NO:21IRTSTHN029]Foundation of National Key Program of Research and Development of China[Grant NO:2016YFC0900803]+1 种基金Key Research Program of Colleges and Universities in Henan Province[Grant NO:21A330007]Discipline Key Research and Development Program of Zhengzhou University[Grant NO:XKZDQY202008,XKZDQY202002]。
文摘Type 2 diabetes mellitus(T2DM)is recognized as a heterogeneous and complicated disease that is able to influence individuals at various life stages[1].Apart from traditional predictors such as age,family history of diabetes,body mass index,and so on,ambient air pollution is also shown to increase the risk of T2DM in previous studies.
基金supported by the National Natural Science Foundation of China(NSFC),No.31201878,81172716,and U1204804Post Doctoral Foundation of China,No.2015M572109Post Doctoral Fund of Henan province,No.2014049
文摘Lead exposure is a known potential risk factor for neurodegenerative diseases such as Alzheimer’s disease (AD). Exposure to lead during the critical phase of brain development has been linked with mental retardation and hypophrenia in later life.
基金supported by the National Key Research and Development Program Precision Medicine Initiative of China[grant number:2016YFC0900803]National Natural Science Foundation of China[grant number:81872626,82003454]+2 种基金Chinese Nutrition Society-Bright Moon Seaweed Group Nutrition and Health Research Fund[grant number:CNS-BMSG2020A63]Chinese Nutrition Society-Zhendong National Physical Fitness and Health Research Fund[grant number:CNS-ZD2019066]Key R&D and promotion projects in Henan Province[grant number:212102310219]。
文摘Objective To our knowledge, no definitive conclusion has been reached regarding the relationship between glucocorticoids and hypertension. Here, we aimed to explore the characteristics of glucocorticoids in participants with dysglycemia and hypertension, and to analyze their association with blood pressure indicators.Methods The participants of this study were from the Henan Rural Cohort study. A total of 1,688 patients 18–79 years of age were included in the matched case control study after application of the inclusion and exclusion criteria. Statistical methods were used to analyze the association between glucocorticoids and various indices of blood pressure, through approaches such as logistic regression analysis, trend tests, linear regression, and restricted cubic regression.Results The study population consisted of 552 patients with dysglycemia and hypertension(32.7%).The patients with co-morbidities had higher levels of serum cortisol(P = 0.009) and deoxycortisol(P <0.001). The adjusted odds ratios(and 95% confidence intervals) for dysglycemia with hypertension were1.55(1.18, 2.04) for the highest tertile of Ln-cortisol compared with the lowest tertile. Additionally, the highest Ln-deoxycortisol levels were associated with increased prevalence of dysglycemia with hypertension by 159%(95% confidence interval: 122%, 207%).Conclusions Serum deoxycortisol was positively correlated with systolic blood pressure, pulse pressure, mean arterial pressure, mean blood pressure, and mean proportional arterial pressure.Glucocorticoids(deoxycortisol and cortisol) increase the risk of hypertension in people with dysglycemia, particularly in those with T2 DM.
基金supported by the Foundation of National Key Program of Research and Development of China[grant No.2016YFC0900803]Science and Technology Innovation Team Support Plan of Colleges and Universities in Henan Province[grant No.21IRTSTHN029]+4 种基金National Natural Science Foundation of China[grant No.81573243 and 81602925]Henan Natural Science Foundation of China[grant No.182300410293]Science and Technology Foundation for Innovation Talent of Henan Province[grant No.164100510021]Science and Technology Innovation Talents Support Plan of Henan Province Colleges and Universities[grant No.14HASTIT035]High-level Personnel Special Support Project of Zhengzhou University[grant No.ZDGD13001]。
文摘Metabolic syndrome(MetS),a cluster of modifiable metabolic conditions(including abdominal obesity,dyslipidemia,elevated blood pressure,and hyperglycemia),has become an essential contributor to the global health burden and public health challenges worldwide.