It has been recognized that physical and chemical properties of biomaterial surfaces mediate the quality of extracellular matrix(ECM)that may affect cell behaviors.In nature,ECM is a heterogeneous three-dimensional su...It has been recognized that physical and chemical properties of biomaterial surfaces mediate the quality of extracellular matrix(ECM)that may affect cell behaviors.In nature,ECM is a heterogeneous three-dimensional superstructure formed by three major components,glycosaminoglycan,glycoconjugate,and protein,that anchors cellular compartments in tissues and regulates the function and the behavior of cells.Changes in the biointerface alter the quality of ECM and morphology through cell surface receptors,which,in turn,enable it to trigger specific cell signaling and different cellular responses.In fact,a number of strategies have been used to improve the functionality of surfaces and direct cell behavior through precisely designed environments.Herein,we aimed to discuss,through a science-based viewpoint,the biomaterial surface features on cell behavior and analyze the impact of cell physical modification on dental implant development.展开更多
基金Pereira MMA is currently supported by grant provided by Coordination for the Improvement of Higher Education Personnel(CAPES#88887.573209/2020-00)finance code 001de Molon RS was supported by grant provided by CAPES(Coordenação de Aperfeiçoamento de Pessoal de Nível Superior)Grant#88887.583248/2020-00de Avila ED was supported by grant provided by FAPESP(The São Paulo Research Foundation)grant#2018/20719-3.
文摘It has been recognized that physical and chemical properties of biomaterial surfaces mediate the quality of extracellular matrix(ECM)that may affect cell behaviors.In nature,ECM is a heterogeneous three-dimensional superstructure formed by three major components,glycosaminoglycan,glycoconjugate,and protein,that anchors cellular compartments in tissues and regulates the function and the behavior of cells.Changes in the biointerface alter the quality of ECM and morphology through cell surface receptors,which,in turn,enable it to trigger specific cell signaling and different cellular responses.In fact,a number of strategies have been used to improve the functionality of surfaces and direct cell behavior through precisely designed environments.Herein,we aimed to discuss,through a science-based viewpoint,the biomaterial surface features on cell behavior and analyze the impact of cell physical modification on dental implant development.
