目的探讨高血压脑小血管病(Hypertensive cerebral small vessel disease,HT-CSVD)的中医病因病机,梳理HT-CSVD中医药治疗现况及其疗效评价指标。方法基于“风痰瘀虚”立论,从中医基础理论视角系统阐述HT-CSVD的发病机理;并对中医药治疗...目的探讨高血压脑小血管病(Hypertensive cerebral small vessel disease,HT-CSVD)的中医病因病机,梳理HT-CSVD中医药治疗现况及其疗效评价指标。方法基于“风痰瘀虚”立论,从中医基础理论视角系统阐述HT-CSVD的发病机理;并对中医药治疗HT-CSVD文献进行方法学质量评价与牛津证据等级分类总结,归纳其疗效评价指标。结果HT-CSVD的病机为虚则气血津液不足和髓海失养,实则风、痰、瘀犯清窍,邪袭虚处,壅滞清窍而“神”乱;病位在脑窍,与心、肾、肝、脾的虚损相关;“虚”“瘀”“痰”“风”是其重要的病理枢机。当前,HT-CSVD的中医药治疗主要包括益气、活血、补肾、化痰等中药复方或注射液,针刺(取穴主穴为人迎、合谷、太冲等)及其他非药物干预3方面。其疗效评价指标以功能评分量表、影像学特征指标、机制相关生物标记物与中医证候相关有效率与评分等为主。结论本研究对HT-CSVD中医病因病机的解析,以及中医药治疗HT-CSVD的较高证据等级方案与其疗效评价指标的梳理,可望为后续HTCSVD中医药防治专家共识的制订提供参考。展开更多
目的评价虫草制剂治疗糖尿病肾病的系统评价/Meta-分析的方法学和报告质量。方法计算机检索PubMed、Web of Science、CNKI、VIP和万方数据库查找虫草制剂治疗糖尿病肾病的系统评价文献,时间为从建库到2019年10月5日。采用AMSTAR-2量表和...目的评价虫草制剂治疗糖尿病肾病的系统评价/Meta-分析的方法学和报告质量。方法计算机检索PubMed、Web of Science、CNKI、VIP和万方数据库查找虫草制剂治疗糖尿病肾病的系统评价文献,时间为从建库到2019年10月5日。采用AMSTAR-2量表和PRISMA声明对纳入文献进行方法学和报告质量评估。结果共纳入15篇文献。AMSTAR-2量表结果表明文献方法学质量都为极低,PRISMA声明平均得分为18.5分。文献方法学和报告质量的不足主要在方案注册、纳入标准和资金来源方面。结论尽管纳入的文献都表明虫草制剂治疗糖尿病肾病是有效的,但其方法学和报告质量评价较差。临床工作者须谨慎对待系统评价的结果,未来研究者在撰写系统评价时应规范使用AMSTAR-2量表和PRISMA声明。展开更多
Noting that the fundamental requirement for the conservation of biological diversity is the in situ conservation of ecosystems and natural habitats and the maintenance and recovery of viable populations of species in ...Noting that the fundamental requirement for the conservation of biological diversity is the in situ conservation of ecosystems and natural habitats and the maintenance and recovery of viable populations of species in their natural surroundings;and noting further that ex situ measures preferably in the country of origin,also have an important role to play.Here“ex situ conservation(i.e.,conservation by relocation)”refers to the relocation of biodiversity components outside their natural environments for conservation.Each Party shall,to the extent possible and as appropriate,primarily to complement in situ conservation:take measures to relocate the biodiversity components for ex situ conservation,preferably in their countries of origin;establish and maintain facilities for ex situ conservation and research of plants,animals and micro-organisms,preferably in the countries of origin of the genetic resources;take measures to restore and rehabilitate endangered species and,where appropriate,reintroduce these species into their natural habitats;control and manage the collection of biological resources in natural habitats for ex situ conservation purposes in a manner that does not threaten ecosystems and native species communities...展开更多
文摘目的探讨高血压脑小血管病(Hypertensive cerebral small vessel disease,HT-CSVD)的中医病因病机,梳理HT-CSVD中医药治疗现况及其疗效评价指标。方法基于“风痰瘀虚”立论,从中医基础理论视角系统阐述HT-CSVD的发病机理;并对中医药治疗HT-CSVD文献进行方法学质量评价与牛津证据等级分类总结,归纳其疗效评价指标。结果HT-CSVD的病机为虚则气血津液不足和髓海失养,实则风、痰、瘀犯清窍,邪袭虚处,壅滞清窍而“神”乱;病位在脑窍,与心、肾、肝、脾的虚损相关;“虚”“瘀”“痰”“风”是其重要的病理枢机。当前,HT-CSVD的中医药治疗主要包括益气、活血、补肾、化痰等中药复方或注射液,针刺(取穴主穴为人迎、合谷、太冲等)及其他非药物干预3方面。其疗效评价指标以功能评分量表、影像学特征指标、机制相关生物标记物与中医证候相关有效率与评分等为主。结论本研究对HT-CSVD中医病因病机的解析,以及中医药治疗HT-CSVD的较高证据等级方案与其疗效评价指标的梳理,可望为后续HTCSVD中医药防治专家共识的制订提供参考。
文摘目的评价虫草制剂治疗糖尿病肾病的系统评价/Meta-分析的方法学和报告质量。方法计算机检索PubMed、Web of Science、CNKI、VIP和万方数据库查找虫草制剂治疗糖尿病肾病的系统评价文献,时间为从建库到2019年10月5日。采用AMSTAR-2量表和PRISMA声明对纳入文献进行方法学和报告质量评估。结果共纳入15篇文献。AMSTAR-2量表结果表明文献方法学质量都为极低,PRISMA声明平均得分为18.5分。文献方法学和报告质量的不足主要在方案注册、纳入标准和资金来源方面。结论尽管纳入的文献都表明虫草制剂治疗糖尿病肾病是有效的,但其方法学和报告质量评价较差。临床工作者须谨慎对待系统评价的结果,未来研究者在撰写系统评价时应规范使用AMSTAR-2量表和PRISMA声明。
文摘Noting that the fundamental requirement for the conservation of biological diversity is the in situ conservation of ecosystems and natural habitats and the maintenance and recovery of viable populations of species in their natural surroundings;and noting further that ex situ measures preferably in the country of origin,also have an important role to play.Here“ex situ conservation(i.e.,conservation by relocation)”refers to the relocation of biodiversity components outside their natural environments for conservation.Each Party shall,to the extent possible and as appropriate,primarily to complement in situ conservation:take measures to relocate the biodiversity components for ex situ conservation,preferably in their countries of origin;establish and maintain facilities for ex situ conservation and research of plants,animals and micro-organisms,preferably in the countries of origin of the genetic resources;take measures to restore and rehabilitate endangered species and,where appropriate,reintroduce these species into their natural habitats;control and manage the collection of biological resources in natural habitats for ex situ conservation purposes in a manner that does not threaten ecosystems and native species communities...
