A new acyclic peroxide derivative asperoxide A(1),along with 13 known compounds,namely,microperfuranone(2),9-hydroxymicroperfuranone(3),gibellulin A(4),lecanoric acid(5),terrequinone A(6),sterigmatocystin(7),isosecost...A new acyclic peroxide derivative asperoxide A(1),along with 13 known compounds,namely,microperfuranone(2),9-hydroxymicroperfuranone(3),gibellulin A(4),lecanoric acid(5),terrequinone A(6),sterigmatocystin(7),isosecosterigmatocystin(8),arugosin C(9),curvularin(10),3,3'-diindolylmethane(11),austinol(12),austin(13),and dehydroaustin(14),were isolated and identified from the culture extract of Aspergillus nidulans SD-531,a fungus obtained from the deep-sea sediment of cold spring in the South China Sea.Their structures were determined based on detailed interpretation of nuclear magnetic resonance(NMR)spectroscopic and mass spectrometry data analysis.All the isolated compounds were evaluated for antimicrobial activities against human and aquatic bacteria as well as plant pathogenic fungi.Compounds 1–8,10,and 11 exhibited antimicrobial activities against some of the tested strains with minimum inhibitory concentration(MIC)values ranging from^2 to 64μg/mL.Compounds 4 and 6 displayed strongest activities among the tested samples and might be used as promising molecules for the development of natural antimicrobial agents.展开更多
A new aromatic bisabolene-type sesquiterpenoid(7 S,8 S)-8-hydroxysydowic acid(1),together with a pair of new bisabolene derivative(±)-(7 R*,10 R*)-10-hydroxysydowic acid(2),as well as two known analogues hydroxys...A new aromatic bisabolene-type sesquiterpenoid(7 S,8 S)-8-hydroxysydowic acid(1),together with a pair of new bisabolene derivative(±)-(7 R*,10 R*)-10-hydroxysydowic acid(2),as well as two known analogues hydroxysydonic acid(3)and sydowic acid(4)were isolated and identifi ed from the endophytic fungal strain Aspergillus sydowii EN-434 that was obtained from the marine red alga Symphyocladia latiuscula.Their structures were elucidated by nuclear magnetic resonance(NMR),high resolution electrospray ionization mass spectroscopy(HRESIMS),and quantum chemical electronic circular dichroism(ECD)calculations as well as comparison of the data with literature reports.Compound 1 exhibited potent DPPH free radical scavenging activity with IC 50 value of 113.5μmol/L.展开更多
基金the National Key R&D Program of China(No.2018YFC0310800)。
文摘A new acyclic peroxide derivative asperoxide A(1),along with 13 known compounds,namely,microperfuranone(2),9-hydroxymicroperfuranone(3),gibellulin A(4),lecanoric acid(5),terrequinone A(6),sterigmatocystin(7),isosecosterigmatocystin(8),arugosin C(9),curvularin(10),3,3'-diindolylmethane(11),austinol(12),austin(13),and dehydroaustin(14),were isolated and identified from the culture extract of Aspergillus nidulans SD-531,a fungus obtained from the deep-sea sediment of cold spring in the South China Sea.Their structures were determined based on detailed interpretation of nuclear magnetic resonance(NMR)spectroscopic and mass spectrometry data analysis.All the isolated compounds were evaluated for antimicrobial activities against human and aquatic bacteria as well as plant pathogenic fungi.Compounds 1–8,10,and 11 exhibited antimicrobial activities against some of the tested strains with minimum inhibitory concentration(MIC)values ranging from^2 to 64μg/mL.Compounds 4 and 6 displayed strongest activities among the tested samples and might be used as promising molecules for the development of natural antimicrobial agents.
基金Supported by the National Natural Science Foundation of China(Nos.31330009,31600267)。
文摘A new aromatic bisabolene-type sesquiterpenoid(7 S,8 S)-8-hydroxysydowic acid(1),together with a pair of new bisabolene derivative(±)-(7 R*,10 R*)-10-hydroxysydowic acid(2),as well as two known analogues hydroxysydonic acid(3)and sydowic acid(4)were isolated and identifi ed from the endophytic fungal strain Aspergillus sydowii EN-434 that was obtained from the marine red alga Symphyocladia latiuscula.Their structures were elucidated by nuclear magnetic resonance(NMR),high resolution electrospray ionization mass spectroscopy(HRESIMS),and quantum chemical electronic circular dichroism(ECD)calculations as well as comparison of the data with literature reports.Compound 1 exhibited potent DPPH free radical scavenging activity with IC 50 value of 113.5μmol/L.
