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基于真实世界研究方法的中医药研究进展
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作者 张娜 魏天睿 +2 位作者 张子彦 孟庆金 解红霞 《内蒙古医科大学学报》 2023年第5期552-556,共5页
真实世界研究是国内外近几年对药物研发及质量评价的焦点,也被称为现实世界研究。由于此研究在国内起步较晚,而中医药的发展又是我国医药发展的重点关注对象,将真实世界研究的方法应用在中医药领域具有重大意义。真实世界研究因其结果... 真实世界研究是国内外近几年对药物研发及质量评价的焦点,也被称为现实世界研究。由于此研究在国内起步较晚,而中医药的发展又是我国医药发展的重点关注对象,将真实世界研究的方法应用在中医药领域具有重大意义。真实世界研究因其结果更加贴近现实,兼顾科学严谨性的同时也具备反映客观现实的灵活性,在评价中药及中成药疗效时可以丰富审评证据的来源,为药物评价和证据积累提供新的方法和路径。本文对真实世界研究方法和真实世界研究在国内中医药方面的研究进展进行分析,期望为此后真实世界研究在中医药现代化研究中的应用和发展提供新的思路。 展开更多
关键词 真实世界研究 中医药 质量评价 证据积累 研究进展
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碱金属助催合成氨铁催化剂的研究(Ⅴ)——氯离子的效应
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作者 忻新泉 朱龙根 +3 位作者 孟庆金 张雪琴 吴沛成 戴安邦 《高等学校化学学报》 SCIE EI CAS 1982年第2期162-168,共7页
本文指出,氯离子是碱金属助催的合成氨催化剂Fe-AC(活性炭)-K(金属钾)体系的毒物。通过对含氯催化剂的活性测试,配合气相色谱、穆斯堡尔谱以及X-射线衍射图的研究,所得实验結果指出,KCl使催化剂中毒的机制是氯离子引起了高分散的小颗粒... 本文指出,氯离子是碱金属助催的合成氨催化剂Fe-AC(活性炭)-K(金属钾)体系的毒物。通过对含氯催化剂的活性测试,配合气相色谱、穆斯堡尔谱以及X-射线衍射图的研究,所得实验結果指出,KCl使催化剂中毒的机制是氯离子引起了高分散的小颗粒α-Fe的聚结,本文还讨论了氯离子对Fe体系和Ru体系催化剂的不同影响,归之于Fe系合成氨催化剂的结构敏感性。 展开更多
关键词 铁催化剂 结构敏感性 合成氨催化剂 活性测试 穆斯堡尔谱 催化剂中毒 气相色谱 碱金属
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双核钴簇合物(C_(6)H_(5)C2R)Co_(2)(CO)_(6)的合成
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作者 孟庆金 孙守恒 +1 位作者 步修仁 游效曾 《高等学校化学学报》 SCIE EI CAS 1988年第8期856-858,共3页
羰基钴簇合物Co_(2)(CO)8可用于有机合成的催化剂。但Co_(2)(CO)8本身不稳定,易被氧化。因此,研究不向CO_(2)簇合物的稳定性及其催化性能具有一定的意义。实验表明,用快烃RC2R′(R=R′或R(?)R′)取代Co_(2)(CO)_(8)中的2个Co所生成的新... 羰基钴簇合物Co_(2)(CO)8可用于有机合成的催化剂。但Co_(2)(CO)8本身不稳定,易被氧化。因此,研究不向CO_(2)簇合物的稳定性及其催化性能具有一定的意义。实验表明,用快烃RC2R′(R=R′或R(?)R′)取代Co_(2)(CO)_(8)中的2个Co所生成的新型簇合物(RC2R′)Co_(2)(CO)6就比Co_(2)(CO)8稳定得多。 展开更多
关键词 双核钴簇合物 炔烃 共轭 Hammett常数 合成
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吗啉双胍配合物的合成和EPR研究 被引量:1
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作者 管荫桐 汪义军 +1 位作者 孟庆金 唐雯霞 《高等学校化学学报》 SCIE EI CAS 1988年第4期311-316,共6页
本文报道了十三种新的吗啉双胍配合物的合成、性质及结构特征。
关键词 吗啉双胍 铜配合物 EPR谱
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Dongbeititan dongi,the First Sauropod Dinosaur from the Lower Cretaceous Jehol Group of Western Liaoning Province,China 被引量:10
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作者 WANG Xuri YOU Hailu +3 位作者 meng qingjin GAO Chunling CHENG Xiaodong LIU Jinyuan 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2007年第6期911-916,共6页
We herein describe a partial postcranial skeleton of a sauropod dinosaur recovered from the Lower Cretaceous Jehol Group in the Beipiao area of western Liaoning Province, northeastern China. A suite of features it pos... We herein describe a partial postcranial skeleton of a sauropod dinosaur recovered from the Lower Cretaceous Jehol Group in the Beipiao area of western Liaoning Province, northeastern China. A suite of features it possesses, including the camellate internal structure of its presacral elements, the existence of pneumatocoels on the proximal ends of the dorsal ribs, and especially the medially deflected proximal portion of the femur, definitively establish the titanosauriform affinities of the specimen. It differs from other titanosauriforms in having a craniocaudally elongate coracoid with a squared cranioventral extreme and a long, smooth, and slightly convex acetabular edge of the pubis. It represents a new taxon, Dongbeititan dongi gen. et sp. nov. Comparative studies suggest that Dongbeititan is a basal titanosauriform, more derived than Euhelopus, Fusuisaurus, and Huanghetitan, but less derived than Gobititan and Jiutaisaurus. Dongbeititan represents the first sauropod dinosaur reported from the Lower Cretaceous Jehol Group of western Liaoning Province. 展开更多
关键词 DINOSAURIA SAUROPODA TITANOSAURIFORMES Jehol Group Yixian Formation Lower Cretaceous Beipiao western Liaoning Province China
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On the Systematic Position of Eosipterus yangi Ji et Ji,1997 among Pterodactyloids 被引量:4
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作者 LU Junchang GAO Chunling +2 位作者 meng qingjin LIU Jinyuan JI Qiang 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2006年第5期643-646,共4页
A comparison of the new specimen with the holotype of Eosipterus from western Liaoning Province indicates that Eosipterus is a valid genus, which belongs to the family Ctenochasmatidae. The revised diagnosis of Eosipt... A comparison of the new specimen with the holotype of Eosipterus from western Liaoning Province indicates that Eosipterus is a valid genus, which belongs to the family Ctenochasmatidae. The revised diagnosis of Eosipterus includes the wing span is less than 1.25 meters, the length of the ulna is nearly equal to these of wing phalanx 2 and the tibia, humerus is longer than tibia, and the ratio of metatarsal to tibia is approximately 0.40. 展开更多
关键词 Eosipterus systematic position Yixian Formation western Liaoning
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New Material of Pterosaur Sinopterus (Reptilia:Pterosauria) from the Early Cretaceous Jiufotang Formation,Western Liaoning,China 被引量:1
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作者 Lü Junchang LIU Jinyuan +3 位作者 WANG Xuri GAO Chunling meng qingjin JI Qiang 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2006年第6期783-789,共7页
Based on a new nearly complete postcranial skeleton of an adult specimen of Sinopterus from the Early Cretaceous Jiufotang Formation of western Liaoning, China, the diagnosis of Sinopterus is amended. The revised diag... Based on a new nearly complete postcranial skeleton of an adult specimen of Sinopterus from the Early Cretaceous Jiufotang Formation of western Liaoning, China, the diagnosis of Sinopterus is amended. The revised diagnosis of Sinopterus includes skull relatively elongate with weakly developed cranial crest; ratio of the length of Ph2d4 to that of Ph1d4 is approximately 0.73; ratio of the length of wing metacarpal to that of metatarsal 3 is 4.5; ratio of the length of mt3 to that of tibia is approximately 0.21, and wing phalanges 1 and 2 are straight. Comparison between the ratios of the limb bones between non-adult and adult individuals of Sinopterus indicates that during the ontogenetic process, some ratios between bones are constant, such as the first wing phalanx to the second wing phalanx, the wing metacarpal to the metatarsal 3, metatarsal 3 to the tibia, but others are not, such as humerus to wing metacarpal and femur to tibia, in which the former grows faster than the latter. 展开更多
关键词 Sinopterus amended diagnosis ONTOGENY Jiufotang Formation Early Cretaceous western Liaoning China
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复合玛咖片的毒理学安全性评价 被引量:1
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作者 张悦 张朋朋 +5 位作者 孟庆金 董鹏 杨彩玲 王学南 张鹏 田世民 《中国老年保健医学》 2021年第5期59-63,共5页
目的对复合玛咖片进行食用安全性评价。方法急性毒性实验选用ICR小鼠雌、雄各半,共20只,24小时内两次经口灌胃给予受试物,观察小鼠14d的中毒表现及死亡情况。Ames实验采用经鉴定符合要求的组氨酸缺陷型鼠伤寒沙门氏菌TA97a、TA98、TA100... 目的对复合玛咖片进行食用安全性评价。方法急性毒性实验选用ICR小鼠雌、雄各半,共20只,24小时内两次经口灌胃给予受试物,观察小鼠14d的中毒表现及死亡情况。Ames实验采用经鉴定符合要求的组氨酸缺陷型鼠伤寒沙门氏菌TA97a、TA98、TA100、TA102四个菌株进行实验,整个实验在相同条件下重复一次。骨髓细胞微核实验选ICR小鼠,雌、雄各半,共50只,实验设3个剂量组,分别为6.0g/(kg·BW)、3.0g/(kg·BW)、1.5g/(kg·BW),另设阴性对照组及阳性对照组。小鼠精子畸形实验选ICR小鼠,雄性,共25只,实验设3个剂量组,分别为6.0g/(kg·BW)、3.0g/(kg·BW)、1.5g/(kg·BW),另设阴性对照组及阳性对照组。30天喂养实验选SD大鼠,雌、雄各半,共80只,分为对照组及3个实验组。灌胃30天后采血,进行血液学指标检测及血液生化指标检测,并进行解剖,取对照组和高剂量组进行组织病理学检查。结果小鼠急性毒性实验经口最大耐受剂量(MTD)均>18.0g/(kg·BW)。三项遗传毒性实验(Ames实验、骨髓细胞微核实验、小鼠精子畸形实验)结果均为阴性,30天喂养实验,实验期间雌、雄性动物生长状况良好,未见受试物对动物体重、增重及食物利用率产生不良影响;未见受试物对动物血液学、血生化相关指标产生不良影响;大体解剖检查,各剂量组动物均未见脏器明显异常,脏器湿重、脏体比未见异常;组织病理学检查,未见被检脏器存在与受试物相关的组织病理学改变。结论复合玛咖片在本实验剂量范围内具有食用安全性。 展开更多
关键词 复合玛咖片 保健食品 毒理 安全性
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New Material of Sinosauropteryx (Theropoda: Compsognathidae) from Western Liaoning, Chinae 被引量:1
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作者 JI Shu'an GAO Chunling +2 位作者 LIU Jinyuan meng qingjin JI Qiang 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2007年第2期177-182,共6页
An incomplete specimen of Sinosauropteryx prima collected from the Early Cretaceous Yixian Formation of the Dawangzhangzi area in Lingyuan, western Liaoning is depicted. It represents the first systematically describe... An incomplete specimen of Sinosauropteryx prima collected from the Early Cretaceous Yixian Formation of the Dawangzhangzi area in Lingyuan, western Liaoning is depicted. It represents the first systematically described material of this feathered compsognathid outside the Sihetun area in Beipiao. This specimen shows some diagnostic features of Sinosauropteryx prima, such as the very short forelimb in relation to hindlimb with the length ratio of humerus plus radius to femur plus tibia just around 30%, and the long and massive first manual ungual subequal in length to radius. The presence of Sinosauropteryx prima only at Sihetun and Dawangzhangzi supports the suggestion that the fossil-bearing beds in the Sihetun and Dawangzhangzi areas are equivalent to each other within the Yixian Formation. 展开更多
关键词 Sinosauropteryx Lingyuan LIAONING Yixian Formation stratigraphic correlation Cretaceous
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The adsorption of 2,5-dimer-capto-1,3,4-thiadiazole (DMTD) on copper surface and its binding behavior 被引量:1
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作者 HUANG Ling SHEN Jian +2 位作者 REN Jun meng qingjin YU Tsing 《Chinese Science Bulletin》 SCIE EI CAS 2001年第5期387-390,共4页
The interaction mechanism of 2,5-dimercapto-1,3,4-thiadiazole (DMTD) on copper surface was studied by surface-enhanced Raman scattering (SERS), infrared (IR) and X-ray photoelectron spectroscopy (XPS) techniques. The ... The interaction mechanism of 2,5-dimercapto-1,3,4-thiadiazole (DMTD) on copper surface was studied by surface-enhanced Raman scattering (SERS), infrared (IR) and X-ray photoelectron spectroscopy (XPS) techniques. The SERS spectra were obtained. We found that DMTD bound with the copper via its two-excocyclic mercapto groups. The monosulphide salt was formed. At the same time, DMTD coordinated with the Cu+ ion through the excocyclic mercapto groups and polymerized via the Cu+ ion into a one-dimensional polymer chain on the copper surface. 展开更多
关键词 2 5-dimercapto-1 3 4-thiadiazole (DMTD) surface-enhanced RAMAN scattering (SERS) ADSORPTION and binding.
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