A series of new amino alcohol derivatives was synthesized and evaluated for their immunosuppressive activity on mouse peripheral blood lymphocytes.The structures were confirmed by means of 1H NMR,13C NMR,IR and MS.Mos...A series of new amino alcohol derivatives was synthesized and evaluated for their immunosuppressive activity on mouse peripheral blood lymphocytes.The structures were confirmed by means of 1H NMR,13C NMR,IR and MS.Most of the compounds display moderate to potent inhibitory activity.Compound 9d shows the most activity among them that are expected as a powerful candidate for safer immunosuppressant for organ transplantations and the treatment of autoimmune diseases.展开更多
A series of new amino alcohols derivatives was synthesized with 6-bromo-2-tetralone as starting material, 6-substituted-2-tetralone as intermediate and Ullmann reaction, Suzuki reaction and spiro-hydantoin hydrolysis ...A series of new amino alcohols derivatives was synthesized with 6-bromo-2-tetralone as starting material, 6-substituted-2-tetralone as intermediate and Ullmann reaction, Suzuki reaction and spiro-hydantoin hydrolysis as key steps. The structures of key intermediate and target compounds were confirmed by 1H NMR, 13C NMR, IR and MS. Bioactivity researches show that the target compounds have certain inhibition effects on mice peripheral blood lymphocytes.展开更多
Thymopentin derivative（septapeptide） was prepared by means of the solid-phase peptide synthesis method in which stepwise and segment condensations were involved. The structures of the key intermediate and target mol...Thymopentin derivative（septapeptide） was prepared by means of the solid-phase peptide synthesis method in which stepwise and segment condensations were involved. The structures of the key intermediate and target molecule were confirmed by ESI-MS, elementary analysis, IR,^1H NMR and ^13C NMR spectrometries in our experiments. In this study, the authors found that both thymopentin derivetive（septapeptide） and thymopentin could promote T cell proliferation and increase of E-rose fomation cells.展开更多
In consideration of the anti-HIV activities of delavirdine, resveratrol and Pidotimod, a novel kind of anti-AIDs drug（compounds 5 and 7） was synthesized. Compound 5 was synthesized by linking the delavirdine derivat...In consideration of the anti-HIV activities of delavirdine, resveratrol and Pidotimod, a novel kind of anti-AIDs drug（compounds 5 and 7） was synthesized. Compound 5 was synthesized by linking the delavirdine derivative to pidotimod, compound 7 was synthesized via linking the delavirdine derivative to resveratrol with terephthalic acid as the conjugated compound by two different routes. The structures were confirmed by means of IH NMR, 13C NMR, IR, MS and elemental analysis. The results for HIV-1 reverse transcriptase assay, quantitative titration of HIV-1 by using MAGI assay and pharmacokinetics assay show that a novel kind of anti-AIDs drug has been synthesized.展开更多
基金Supported by the Fund of Jilin University(China) Hi-Tech(Group) Co.Ltd
文摘A series of new amino alcohol derivatives was synthesized and evaluated for their immunosuppressive activity on mouse peripheral blood lymphocytes.The structures were confirmed by means of 1H NMR,13C NMR,IR and MS.Most of the compounds display moderate to potent inhibitory activity.Compound 9d shows the most activity among them that are expected as a powerful candidate for safer immunosuppressant for organ transplantations and the treatment of autoimmune diseases.
文摘A series of new amino alcohols derivatives was synthesized with 6-bromo-2-tetralone as starting material, 6-substituted-2-tetralone as intermediate and Ullmann reaction, Suzuki reaction and spiro-hydantoin hydrolysis as key steps. The structures of key intermediate and target compounds were confirmed by 1H NMR, 13C NMR, IR and MS. Bioactivity researches show that the target compounds have certain inhibition effects on mice peripheral blood lymphocytes.
基金Supported by the Scientific and Technological Development Program Foundation of Jilin Province(No.20070925).
文摘Thymopentin derivative（septapeptide） was prepared by means of the solid-phase peptide synthesis method in which stepwise and segment condensations were involved. The structures of the key intermediate and target molecule were confirmed by ESI-MS, elementary analysis, IR,^1H NMR and ^13C NMR spectrometries in our experiments. In this study, the authors found that both thymopentin derivetive（septapeptide） and thymopentin could promote T cell proliferation and increase of E-rose fomation cells.
基金Supported by Scientific and Technological Development Program Foundation of Jilin Province,China(No.20020503-11)
文摘In consideration of the anti-HIV activities of delavirdine, resveratrol and Pidotimod, a novel kind of anti-AIDs drug（compounds 5 and 7） was synthesized. Compound 5 was synthesized by linking the delavirdine derivative to pidotimod, compound 7 was synthesized via linking the delavirdine derivative to resveratrol with terephthalic acid as the conjugated compound by two different routes. The structures were confirmed by means of IH NMR, 13C NMR, IR, MS and elemental analysis. The results for HIV-1 reverse transcriptase assay, quantitative titration of HIV-1 by using MAGI assay and pharmacokinetics assay show that a novel kind of anti-AIDs drug has been synthesized.
