Achieving high-capacity and long-life K^(+)storage enabled by constructing yolk-shell Sb_(2)S_(3)@N,S-doped carbon nanorod anodes

As promising anode candidates for potassium-ion batteries(PIBs),antimony sulfide(Sb_(2)S_(3))possesses high specific capacity but suffers from massive volume expansion and sluggish kinetics due to the large K^(+)insertion,resulting in inferior cycling and rate performance.To address these challenges,a yolk-shell structured Sb_(2)S_(3)confined in N,S co-doped hollow carbon nanorod(YS-Sb_(2)S_(3)@NSC)working as a viable anode for PIBs is proposed.As directly verified by in situ transmission electron microscopy(TEM),the buffer space between the Sb_(2)S_(3)core and thin carbon shell can effectively accommodate the large expansion stress of Sb_(2)S_(3)without cracking the shell and the carbon shell can accelerate electron transport and K^(+)diffusion,which plays a significant role in reinforcing the structural stability and facilitating charge transfer.As a result,the YS-Sb_(2)S_(3)@NSC electrode delivers a high reversible K^(+)storage capacity of 594.58 m A h g^(-1)at 0.1 A g^(-1)and a long cycle life with a slight capacity degradation(0.01%per cycle)for 2000 cycles at 1 A g^(-1)while maintaining outstanding rate capability.Importantly,utilizing in in situ/ex situ microscopic and spectroscopic characterizations,the origins of performance enhancement and K^(+)storage mechanism of Sb_(2)S_(3)were clearly elucidated.This work provides valuable insights into the rational design of high-performance and durable transition metal sulfides-based anodes for PIBs.

特发性肠系膜静脉肌内膜增生症临床病理特征观察及文献回顾

目的探讨特发性肠系膜静脉肌内膜增生症临床病理特征。方法收集1例少见的特发性肠系膜静脉肌内膜增生症,通过回顾临床信息、组织形态特点,复习国内外相关文献,总结其临床病理特征。结果患者女性,30岁,间断性右下腹痛6个月余。以克罗恩病治疗无效,随后手术切除右半结肠。术前活检见固有层纤维素沉积及黏膜下层“动脉化”毛细血管;手术标本发现肠系膜侧显著的中小静脉肌内膜增生,部分静脉腔显著狭窄或闭塞,弹力纤维染色提示内膜下弹力纤维增生紊乱,考虑特发性肠系膜静脉肌内膜增生。结论特发性肠系膜静脉肌内膜增生症是一种少见的缺血性结肠炎,确诊依赖手术标本肠系膜中小静脉肌内膜的增生,活检标本内皮下纤维蛋白沉积和毛细血管“动脉化”或可帮助诊断。

至味在人间:城市烟火气游客体验的探索性研究

烟火气是具有中国文化意蕴的词汇,与中国人的生活息息相关,城市烟火气为城市休闲、游客体验注入了新颖活力,然而,目前烟火气尚未受到学术界的关注,这也成为旅游体验理论可进一步深化研究的关键方向。文章透过烟火气这一滤镜去审视城市游客体验,建构了传统文化意蕴下的烟火气作为城市目的地文化符号的意象和学术内涵,运用深度访谈法获悉游客体验烟火气的过程,基于“认知-情感-行为”体验的框架,构建了城市烟火气游客体验的理论模型,实现了城市旅游体验研究的创新;揭示了烟火气游客体验的过程,丰富了基于游客情感体验的基础性理论;通过发现烟火气感知下的游客“家乡”情结在目的地地方认同形成机理中的关键作用,为城市游客地方感研究的深化作出了理论贡献。此外,该研究也提出了打造烟火气体验消费、创设复合空间等有益的实践启示,以及跨文化情境下烟火气感知差异、美食和民俗活动的关键作用等未来的研究展望。

正交试验法结合主成分分析优选消瘀凝胶膏提取工艺

目的优选消瘀凝胶膏的提取工艺。方法以挥发油含量为评价指标,以加水量、浸泡时间、提取时间为影响因素,采用L_(9)(3^(4))正交试验法优选挥发油提取工艺,并验证。以干膏得率及积雪草苷、木犀草素、黄芩苷含量为评价指标,以主成分综合得分为综合指标,以乙醇体积分数、溶剂用量、提取次数为考察因素,采用L_(9)(3^(4))正交试验法优选非挥发性成分提取工艺,并验证。结果挥发油最佳提取工艺为加10倍量水,浸泡1.0 h,提取6 h;25 g药材(荆芥、乳香、没药及当归)挥发油含量为1.6 mL。非挥发性成分最佳提取工艺为,以10倍量60%乙醇为溶剂,提取3次,每次1 h。验证试验中平均综合评分为125.36分,RSD为0.49%(n=3)。结论优选工艺稳定可行,最大限度保留了可能有效成分,为新药开发奠定了基础。

Integrability Tests and Some New Soliton Solutions of an Extended Potential Boiti-Leon-Manna-Pempinelli Equation

This paper is devoted to the study of a (2 + 1)-dimensional extended Potential Boiti-Leon-Manna-Pempinelli equation. Firstly, By means of the standard Weiss Tabor Carnevale approach and Kruskal’s simplification, we prove the painlevé non integrability of the equation. Secondly, A new breather solution and lump type solution are obtained based on the parameter limit method and Hirota’s bilinear method. Besides, some interaction behavior between lump type solution and N-soliton solutions (N is any positive integer) are studied. We construct the existence theorem of the interaction solution and give the process of calculation and proof. We also give a concrete example to illustrate the effectiveness of the theorem, and some spatial structure figures are displayed to reflect the evolutionary behavior of the interaction solutions with the change of soliton number N and time t.

基于RPM和SPM的辐射探测技术在危险品伪瞒报检测中的应用

以海关监管查发硝酸钾、烟花爆竹伪瞒报进出口走私为例,讨论了基于RPM和SPM设备的辐射探测技术及其在检测具有放射性属性危险品中的应用。研究结果表明,基于RPM和SPM检测的硝酸钾与烟花爆竹的辐射计数率特征与申报货物的辐射特征不一致,以此可以判断存在伪瞒报嫌疑。设备对硝酸钾的活度响应可以超过RPM和SPM设备报警阈值,最大净计数率增加为216.4%,并且SPM设备可以在短时间内正确识别出核素40K。烟花爆竹中鞭炮药放射性相对较低,四批查发货物中,最大净计数率增加为19.9%,可以触发RPM设备高报警阈值,但SPM设备无法在短时间内识别出核素。通过合理设置设备报警阈值,辐射探测技术可以作为有效的技术手段,应用于海关打击危险品伪瞒报走私。

数字经济赋能区域共同富裕的作用机制及提升路径分析——以新疆为例

[研究目的]在政策和技术双重驱动下,新疆县市的数字经济呈现出良好发展趋势,数字产业比例逐年攀升,且增速超越了全国平均水平。然而,新疆的数字经济仍面临一些瓶颈问题,包括基础设施建设滞后、数字政策支持体系不完善以及数字技能培训匮乏等。故应聚焦于“十四五”时期数字经济如何助力新疆各县市实现共同富裕的具体问题。[研究方法]根据国内外相关研究的文献综述,分析新疆数字经济发展现状及其作用机制,给出了提升路径和政策建议。[研究结论]为解决上述问题,提出了“数字农业+电商+农户”“数字产业+创新创业+就业”“数字基建+公共服务+民生”等发展模式。在提升路径方面,建议加强数字基础设施建设,推动数字人才的培养与创新能力提升,完善数字政策支持机制,并促进数字经济与传统产业的一体化发展。从政策规划层面,强调需要加强数字政策的支持机制,确保政策的前瞻性、实效性与可操作性。同时,加强政策实施评估,保证公开透明,接受公众监督。

复方桦褐孔菌咀嚼片的制备及对高血脂症小鼠降血脂作用

为研发一种以桦褐孔菌和山楂为原料药制备的咀嚼片,并对成品的降血脂作用进行验证。本研究采用单因素方法和响应面试验优化咀嚼片最优制备工艺,测定小鼠血清中胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、谷丙转氨酶(ALT)及谷草转氨酶(AST)的水平变化,判断咀嚼片降血脂作用。结果表明,最佳处方工艺为30%主药,42.48%淀粉,26%甘露醇,0.02%阿斯巴甜以及1.5%硬脂酸镁;60%乙醇为润湿剂,过14目筛制粒,65℃干燥35 min。制备所得的咀嚼片可显著降低TC、TG、LDL-C、ALT、AST水平,复方桦褐孔菌咀嚼片可以显著改善高脂血症小鼠血脂水平,修复高脂饮食诱发的肝细胞损伤,具有明显的降血脂作用。

基于区块链技术的医疗信息共享研究综述

随着医疗信息共享的持续发展,数据安全、数据一致性、数据可控性和数据准确性逐渐受到关注。区块链技术因其去中心化、不可窜改和可追溯的特性被认为是解决医疗信息共享问题的有效手段,已有许多基于区块链的医疗信息共享方案涌现。旨在对基于区块链的医疗信息共享方案进行综合分析,探讨其优势、不足以及面临的挑战,为未来研究提供参考,推动该领域方案的进一步发展和完善。总结基于区块链的医疗信息共享方案,重点关注区块链模式、数据安全存储、访问控制策略和完整性验证等方面。分析不同方案的优势和不足之处,比较各方案的特点,探讨其在解决医疗信息共享问题中的效果。提出未来研究方向和发展建议,以促进基于区块链的医疗信息共享方案的进一步完善和创新。聚焦于基于区块链的医疗信息共享方案,涵盖区块链技术在医疗信息共享中的应用、数据安全、访问控制、完整性验证等相关主题。通过系统性的比较和分析,探讨当前方案的优势与挑战,为未来研究和实践提供指导和参考。

基于区块链的可搜索属性加密技术应用综述

随着信息共享的蓬勃发展,数据隐私安全问题逐渐凸显,催生了区块链技术和可搜索属性加密技术的迅速发展。区块链作为一种去中心化、不可篡改的技术,保障了搜索数据的安全性和完整性,可搜索属性加密技术可以有效地防止非法用户的访问查询。然而随着数据规模和复杂性的增加,出现了检索效率低、查询结果验证复杂、属性权限分发困难等问题。首先,针对以上问题,分别总结了基于区块链的可搜索加密技术、基于区块链的属性加密技术以及基于区块链的可搜索属性加密技术应用的研究现状。其次,对三者之间的优势和侧重点进行了比较分析。最后,重点总结了基于区块链的可搜索属性加密技术在关键字检索、属性权限管理以及数据完整性验证方面的应用,以及所面临的问题和挑战。希望为实现更安全、高效、去中心化的数据存储与共享提供更加安全的技术应用支持。

The“depict”strategy for discovering new compounds in complex matrices:Lycibarbarspermidines as a case

The comprehensive detection and identification of active ingredients in complex matrices is a crucial challenge.Liquid chromatography coupled with high-resolution mass spectrometry(LC-HRMS)is the most prominent analytical platform for the exploration of novel active compounds from complex matrices.However,the LC-HRMS-based analysis workflow suffers from several bottleneck issues,such as trace content of target compounds,limited acquisition for fragment information,and uncertainty in interpreting relevant MS2 spectra.Lycibarbarspermidines are vital antioxidant active ingredients in Lycii Fructus,while the reported structures are merely focused on dicaffeoylspermidines due to their low content.To comprehensively detect the new structures of lycibarbarspermidine derivatives,a“depict”strategy was developed in this study.First,potential new lycibarbarspermidine derivatives were designed according to the biosynthetic pathway,and a comprehensive database was established,which enlarged the coverage of lycibarbarspermidine derivatives.Second,the polarity-oriented sample preparation of potential new compounds increased the concentration of the target compounds.Third,the construction of the molecular network based on the fragmentation pathway of lycibarbarspermidine derivatives broadened the comprehensiveness of identification.Finally,the weak response signals were captured by data-dependent scanning(DDA)followed by parallel reaction monitoring(PRM),and the efficiency of acquiring MS2 fragment ions of target compounds was significantly improved.Based on the integrated strategy above,210 lycibarbarspermidine derivatives were detected and identified from Lycii Fructus,and in particular,170 potential new compounds were structurally characterized.The integrated strategy improved the sensitivity of detection and the coverage of low-response components,and it is expected to be a promising pipeline for discovering new compounds.

PAC心理弹性理论对老年糖尿病患者治疗依从性的影响

目的探究PAC心理弹性理论对老年糖尿病患者治疗依从性的影响。方法选取2022年1月至2023年10月就诊的老年糖尿病患者83例,按照随机数字表法分为对照组(41例,给予常规护理干预)和研究组(42例,给予常规联合PAC心理弹性理论护理干预),观察并对比2组治疗依从性、心理弹性、血糖指标水平以及生活质量。结果在护理结束后,2组总治疗依从率均较护理前有所提升,且研究组总治疗依从率(92.86%)显著高于对照组总治疗依从率(75.61%)(P<0.05);研究组的心理弹性量表(CD-RISC)总分明显高于对照组(P<0.05);与护理前相比,2组的空腹血糖(FPG)、餐后2 h血糖(2hPG)以及糖化血红蛋白(HbA1c)水平均降低,且研究组的水平低于对照组(P<0.05);2组的糖尿病生存质量特异性量(DSQL)总分均下降,且研究组的下降幅度更显著(P<0.05)。结论在老年糖尿病患者的护理干预中,采用PAC心理弹性理论护理能够显著提高治疗依从性,改善血糖水平,并促进生活质量的提高。

乙醇胺对蒸汽发生器排污电离除盐膜堆性能的影响研究

采用电离除盐膜堆(EDI)净化核电厂蒸汽发生器排污水具有诸多优点,目前排污EDI运行经验均基于氨(NH_(3))运行。本文开展研究了乙醇胺(ETA)及其热解产物对EDI运行参数及净化性能的影响。结果表明,进水增加ETA及热解产物不会对EDI运行压差造成明显变化,但EDI运行电阻有增大趋势,会提升运行能耗,EDI产水电阻率会明显降低,工程应用需调整系统对应的报警值。ETA的添加相比纯NH_(3)工况,虽然EDI对Na^(+)、Cl^(-)、SO_(4)^(2-)的去除率略有下降,但出水水质依然满足核电厂运行控制要求。

A Fault Detection Method for Electric Vehicle Battery System Based on Bayesian Optimization SVDD Considering a Few Faulty Samples

Accurate and reliable fault detection is essential for the safe operation of electric vehicles.Support vector data description(SVDD)has been widely used in the field of fault detection.However,constructing the hypersphere boundary only describes the distribution of unlabeled samples,while the distribution of faulty samples cannot be effectively described and easilymisses detecting faulty data due to the imbalance of sample distribution.Meanwhile,selecting parameters is critical to the detection performance,and empirical parameterization is generally timeconsuming and laborious and may not result in finding the optimal parameters.Therefore,this paper proposes a semi-supervised data-driven method based on which the SVDD algorithm is improved and achieves excellent fault detection performance.By incorporating faulty samples into the underlying SVDD model,training deals better with the problem of missing detection of faulty samples caused by the imbalance in the distribution of abnormal samples,and the hypersphere boundary ismodified to classify the samplesmore accurately.The Bayesian Optimization NSVDD(BO-NSVDD)model was constructed to quickly and accurately optimize hyperparameter combinations.In the experiments,electric vehicle operation data with four common fault types are used to evaluate the performance with other five models,and the results show that the BO-NSVDD model presents superior detection performance for each type of fault data,especially in the imperceptible early and minor faults,which has seen very obvious advantages.Finally,the strong robustness of the proposed method is verified by adding different intensities of noise in the dataset.

血清前列腺素内过氧化物合酶2、几丁质酶3样蛋白1水平与精神分裂症患者认知功能的关系

目的:探究血清前列腺素内过氧化物合酶2(prostaglandin endoperoxide synthase 2,PTGS2)、几丁质酶3样蛋白1(chitinase 3-like protein 1,CHI3L1)水平与精神分裂症患者认知功能的关系。方法:选取130例精神分裂症患者设为研究组,同期来院体检的96名健康体检者作为对照组。采用精神分裂症认知功能成套测验(MATRICS consensus cognitive battery,MCCB)评分评估研究对象的认知功能。检测两组研究对象血清PTGS2、CHI3L1水平。Pearson法分析精神分裂症患者血清中PTGS2与CHI3L1水平与MCCB评分的相关性。结果:与对照组相比,研究组精神分裂症患者血清PTGS2、CHI3L1水平升高,差异有统计学意义(P均<0.05),精神分裂症患者连线测验、语言记忆、言语流畅、符号编码、迷宫测验、视觉记忆的MCCB分值均降低,差异有统计学意义(P均<0.05)。血清PTGS2、CHI3L1水平与连线测验、语言记忆、言语流畅、符号编码、迷宫测验、视觉记忆的MCCB分值均呈负相关(P均<0.05)。结论:血清PTGS2、CHI3L1水平均与精神分裂症患者的认知功能呈负相关,是评估精神分裂症患者认知功能的潜在标志物。

早发型重度子痫前期患者血清SPA,SPD及Hcy表达及临床意义

目的探讨早发型重度子痫前期(early onset severe pre-eclampsia,EOSP)患者血清表面活性蛋白A(surfactant associated protein A,SPA)、表面活性蛋白D(surfactant associated protein D,SPD)及同型半胱氨酸(homocysteine,Hcy)表达及临床意义。方法选取2020年8月~2021年8月期间邯郸市中心医院诊治的124例EOSP患者为研究对象,以同期60例健康体检孕妇为对照组。酶联免疫吸附实验(ELISA)检测各组血清SPA,SPD及Hcy水平。比较两组一般资料及血清SPA,SPD及Hcy水平的差异。Pearson相关分析血清SPA,SPD及Hcy水平与临床参数的相关性。多因素Logistic回归分析影响EOSP发生的影响因素。受试者工作曲线(ROC)分析血清SPA,SPD及Hcy对EOSP的诊断价值。结果相比于对照组,EOSP组血清SPA(13.27±5.14ng/ml vs 22.14±6.04ng/ml),SPD(8.73±2.38ng/ml vs19.34±3.46ng/ml)水平明显降低,Hcy(15.27±3.13μmol/L vs 8.35±2.32μmol/L)水平明显升高,差异具有统计学意义(t=10.353,24.299,15.214,均P<0.05)。EOSP组患者血清SPA,SPD水平与新生儿出生体质量呈正相关(r=0.515,0.447,均P<0.05),与体质量指数、舒张压、收缩压和24h尿蛋白定量呈负相关(r=-0.604~-0.413,均P<0.05);血清Hcy水平与新生儿出生体质量呈负相关(r=-0.538,P<0.05),与体质量指数、舒张压、收缩压和24h尿蛋白定量呈正相关(r=0.420~0.610,均P<0.05)。24h尿蛋白定量[1.266(1.110~1.444)]、舒张压[1.270(1.071~1.506)]、SPA[0.865(0.778~0.962)],SPD[0.877(0.781~0.985)]及Hcy[1.347(1.084~1.675)]是影响EOSP发生的独立因素。血清SPA,SPD和Hcy联合检测对EOSP诊断的曲线下面积(95%CI)为0.909(0.877~0.945),显著高于SPA,SPD和Hcy各指标单独检测0.780(0.726~0.836),0.758(0.705~0.810),0.740(0.692~0.789),差异具有统计学意义(Z=4.370,5.567,7.702,均P<0.05)。结论子痫前期患者血清SPA和SPD降低,Hcy升高,三者共同参与EOSP疾病发生发展,是影响ES-PE发生的独立危险因素。

B-doped and La_(4)NiLiO_(8)-coated Ni-rich cathode with enhanced structural and interfacial stability for lithium-ion batteries

Ni-rich layered oxides are considered promising cathodes for advanced lithium-ion batteries(LIBs)in the future,owing to their high capacity and low cost.However,the issues on structural and interfacial stability of Ni-rich cathodes still pose substantial obstacles in the practical application of advanced LIBs.Here,we employ a one-step method to synthesize a B-doped and La_(4)NiLiO_(8)-coated LiNi_(0.82)5Co_(0.115)Mn_(0.06)O_(2)(BL-1)cathode with reliable structure and interface,for the first time.The La_(4)NiLiO_(8)coating layer can prevent cathodes from electrolyte assault and facilitate Li+diffusion kinetics.Moreover,B-doping can effectively restrain the pernicious H_(2)-H_(3) phase transition and adjust the orientation of primary particles to a radial alignment,which is obstructive to the arise of microcracks induced by the change of anisotropic volume.Specifically,when tested in pouch cells,the BL-1 cathode exhibits outstanding capacity retention of 93.49%after 500 cycles at 1 C.This dual-modification strategy dramatically enhances the stability of the structure and interface for Ni-rich cathode materials,consequently accelerating the commercialization process of high-energy–density LIBs.

Nucleoside diphosphate-linked moiety X-type motif 15 R139C genotypes impact 6-thioguanine nucleotide cut-off levels to predict thiopurine-induced leukopenia in Crohn’s disease patients

BACKGROUND Thiopurine-induced leukopenia(TIL)is a life-threatening toxicity and occurs with a high frequency in the Asian population.Although nucleoside diphosphate-linked moiety X-type motif 15(NUDT15)variants significantly improve the predictive sensitivity of TIL,more than 50%of cases of this toxicity cannot be predicted by this mutation.The potential use of the 6-thioguanine nucleotide(6TGN)level to predict TIL has been explored,but no decisive conclusion has been reached.Can we increase the predictive sensitivity based on 6TGN by subgrouping patients according to their NUDT15 R139C genotypes?AIM To determine the 6TGN cut-off levels after dividing patients into subgroups according to their NUDT15 R139C genotypes.METHODS Patients’clinical and epidemiological characteristics were collected from medical records from July 2014 to February 2017.NUDT15 R139C,thiopurine S methyltransferase,and 6TGN concentrations were measured.RESULTS A total of 411 Crohn’s disease patients were included.TIL was observed in 72 individuals with a median 6TGN level of 323.4 pmol/8×10^8 red blood cells(RBC),which was not different from that of patients without TIL(P=0.071).Then,we compared the 6TGN levels based on NUDT15 R139C.For CC(n=342)and CT(n=65)genotypes,the median 6TGN level in patients with TIL was significantly higher than that in patients without(474.8 vs 306.0 pmol/8×10^8 RBC,P=9.4×10-^5;291.7 vs 217.6 pmol/8×10^8 RBC,P=0.039,respectively).The four TT carriers developed TIL,with a median 6TGN concentration of 135.8 pmol/8×10^8 RBC.The 6TGN cut-off levels were 411.5 and 319.2 pmol/8×108 RBC for the CC and CT groups,respectively.CONCLUSION The predictive sensitivity of TIL based on 6TGN is dramatically increased after subgrouping according to NUDT15 R139C genotypes.Applying 6TGN cut-off levels to adjust thiopurine therapies based on NUDT15 is strongly recommended.

Clinical study on the minimally invasive percutaneous nephrolithotomy treatment of upper urinary calculi

BACKGROUND Upper urinary tract stones are very common in my country,with an incidence of 1%to 5%in the North and an even higher incidence of 5%to 10%in the south.The incidence rate in the south is higher than that in the north,mainly due to the water quality,climate and eating habits of the region.From the perspective of sex,incidence is more likely in males than females.In the high-incidence population,young adults are most prone to stones.Men in the age range of 25 to 40 years are more likely to have stones.AIM To observe the therapeutic effect of minimally invasive percutaneous nephrolithotomy(mPCNL)on upper urinary tract stones and its influence on the renal function of patients.METHODS Patients with upper urinary tract stones who were treated in our hospital from February 2017 to March 2018 were selected as research subjects and were divided into the PCNL group and the mPCNL group according to the random number table method.The general conditions of the two groups of patients were observed during the perioperative period,and the differences in stone clearance,pain,renal function indicators and complication rates were compared between the two groups to determine which were statistically significant(P<0.05).RESULTS The operation time of the mPCNL group was longer than that of the PCNL group(t=-34.392,P<0.001),and the intraoperative blood loss of the mPCNL group was more than that of the PCNL group(t=34.090,P<0.001).There was no difference in renal function indices between the two groups of patients before treatment,and there was no difference in the levels of serum creatinine,β2 microglobulin or retinol binding protein in the mPCNL group after treatment.The visual analog scale score of patients in the mPCNL group was lower than that of the PCNL group(t=12.191,P<0.001),and there was no significant difference in the stone clearance rate between the two groups(χ2 value=1.013,P=0.314).There was no significant difference in the incidence of urine extravasation,dyspnea and peripheral organ damage between the two groups(χ2 value=1.053,P=0.305).At 1 mo after treatment and 3 mo after treatment,the quality of life of the mPCNL group was lower than that of the PCNL group,and the Qmax level of the mPCNL group was higher than that of the PCNL group.CONCLUSION mPCNL has a good therapeutic effect on upper urinary tract stones,with a high stone clearance rate without causing kidney damage or increasing the incidence of complications,and thus has good application value.

海洋放线菌 Nocardiopsis dassonvillei JS106 的抗群体感应活性物质研究

群体感应抑制剂能够通过调控致病菌的群体感应系统来降低其致病力,且不易使其产生抗性突变,有望治疗或协同治疗细菌性感染,以应对细菌耐药性问题。本文研究了一株海洋来源的放线菌达松维尔拟诺卡氏菌JS106中的抗群体感应活性物质。采用减压柱层析和高效液相色谱从JS106的发酵液中分离到6个化合物:1,6-二羟基吩嗪(1)、6-羟基-1-甲氧基吩嗪(2)、4',7-二甲氧基异黄酮(3)、N-(2-羟基苯基)乙酰胺(4)、1-甲氧基吩嗪(5)和2-氨基吩恶嗪-3-酮(6)。在测试浓度下,所有化合物均表现出很好的抗群体感应活性,对紫色色杆菌的色素产生有显著的抑制作用,但没有明显的生长抑制。菌株JS106可产生丰富的吩嗪类化合物,在抗群体感应方面有出色的应用潜力。