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昼夜无创正压通气在慢性阻塞性肺疾病稳定期肺康复治疗中的疗效研究 被引量:11
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作者 周燕娟 缪小辉 +2 位作者 周尧 庄志方 许姣 《实用老年医学》 CAS 2019年第3期269-272,共4页
目的研究昼夜无创正压通气在慢性阻塞性肺疾病(COPD)稳定期病人肺康复治疗中的治疗效果。方法将2015~2016年在本院呼吸科确诊的68例稳定期COPD病人随机分为日间无创组、夜间无创组和锻炼组3组,6个月后比较各组病人在生活质量、呼吸困... 目的研究昼夜无创正压通气在慢性阻塞性肺疾病(COPD)稳定期病人肺康复治疗中的治疗效果。方法将2015~2016年在本院呼吸科确诊的68例稳定期COPD病人随机分为日间无创组、夜间无创组和锻炼组3组,6个月后比较各组病人在生活质量、呼吸困难、运动耐量及肺功能方面的差异。结果 (1)干预前,各组间性别、年龄、吸烟、体质量指数(BMI)、COPD评估测试(CAT)评分、改良的英国医学委员会呼吸困难量表(m MRC)评分、6 min步行距离(6MWD)、第1秒用力呼气容积占预计值的百分比(FEV1%pred)等方面比较,差异均无统计学意义。(2)干预后,3组的CAT评分、m MRC评分、6MWD、FEV1%pred均较干预前显著改善(P<0. 05)。(3)与锻炼组相比,干预后日间无创组及夜间无创组的CAT评分、m MRC评分、6MWD均显著改善(P<0. 05);与日间无创组相比,干预后夜间无创组CAT评分、m MRC评分、6MWD差异无统计学意义(P>0. 05)。(4)干预后3组FEV1%pred差异均无统计学意义(P>0. 05)。结论 COPD稳定期病人肺康复治疗中联合昼、夜使用无创正压通气较单纯康复锻炼更能显著提高其生活质量,改善呼吸困难、运动耐量。 展开更多
关键词 慢性阻塞性肺疾病 无创正压通气 肺康复治疗
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4D CTA与DSA在烟雾病分级中的对比研究 被引量:7
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作者 施红芳 缪小惠 +5 位作者 李子文 许兵 任丽 刘崎 田冰 陆建平 《影像诊断与介入放射学》 2017年第6期476-480,共5页
目的利用4D CTA对烟雾病的血管改变进行Suzuki分级,以DSA为"金标准",评价无创血管成像在烟雾病的血管评估中的应用价值。方法符合入选标准的烟雾病患者101例均行4D CTA及DSA检查,两者检查时间间隔小于1周。由2名神经放射学专... 目的利用4D CTA对烟雾病的血管改变进行Suzuki分级,以DSA为"金标准",评价无创血管成像在烟雾病的血管评估中的应用价值。方法符合入选标准的烟雾病患者101例均行4D CTA及DSA检查,两者检查时间间隔小于1周。由2名神经放射学专家对4D CTA(VR结合MIP)及DSA图像共同进行评估,以DSA作为金标准,参照DSA图像的改良法Suzuki分级,对4D CTA评估烟雾病的血管改变进行相应的评分。将4D CTA与DSA各评分进行一致性检验,并计算4D CTA的Kappa值及其95%可信区间。另外将4D CTA与DSA各评分进行相关性分析。结果 4D CTA与DSA评估烟雾病血管的改良法Suzuki分级的一致性评分Kappa值为0.714(0.649~0.778),相关系数及P值为0.843(0.000)。结论4D CTA对烟雾病的Suzuki分级与DSA具有较强的一致性与相关性,能够无创的作为临床上烟雾病患者严重程度评估的主要手段。 展开更多
关键词 成人 烟雾病 动态容积CT血管成像 数字减影血管造影 分级
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精细化护理在幽闭恐惧症患者MRI检查中的应用 被引量:32
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作者 缪小惠 任丽 +3 位作者 石亚娜 李子文 张姝姝 赵海凤 《中国医学计算机成像杂志》 CSCD 北大核心 2018年第4期352-355,共4页
目的:探讨对接受磁共振检查的幽闭恐惧症患者进行精细化护理的效果。方法:研究在长海医院接受MRI检查的96例幽闭恐惧症患者的临床表现,并应用精细化护理的方法进行处理,并统计分析患者在生命体征和主要症状的前后变化。结果:90例患者通... 目的:探讨对接受磁共振检查的幽闭恐惧症患者进行精细化护理的效果。方法:研究在长海医院接受MRI检查的96例幽闭恐惧症患者的临床表现,并应用精细化护理的方法进行处理,并统计分析患者在生命体征和主要症状的前后变化。结果:90例患者通过工作人员的护理或由家属、工作人员陪同完成了预定扫描,另外,6例不配合而未完成扫描,占检查中的6.3%。在对幽闭恐惧症患者进行精细化护理后,患者的生命体征、主要症状都得到了改善,且P<0.05,差异具有统计学意义。结论:应用精细化护理的方法,能够减轻幽闭恐惧症患者的恐惧心理,有助于完成磁共振成像检查。 展开更多
关键词 精细化护理 幽闭恐惧症 MRI检查 影像科
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D-D、NLR和PLR在慢性阻塞性肺疾病并肺栓塞患者中的变化及临床意义 被引量:5
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作者 徐永谦 濮荔 +2 位作者 钟亚花 缪小辉 庄志方 《临床肺科杂志》 2021年第6期909-912,共4页
目的探讨D-二聚体、中性粒细胞/淋巴细胞比值(Neutrophil/lymphocyte ratio,NLR)和血小板/淋巴细胞比值(Platelet/lymphocyte ratio,PLR)在慢性阻塞性肺疾病(简称慢阻肺)合并肺栓塞患者中的变化及临床意义。方法选择慢阻肺合并肺栓塞患... 目的探讨D-二聚体、中性粒细胞/淋巴细胞比值(Neutrophil/lymphocyte ratio,NLR)和血小板/淋巴细胞比值(Platelet/lymphocyte ratio,PLR)在慢性阻塞性肺疾病(简称慢阻肺)合并肺栓塞患者中的变化及临床意义。方法选择慢阻肺合并肺栓塞患者44例,慢阻肺患者30例,健康体检者30例为对照组,检测并计算各组D-二聚体、NLR和PLR水平,进行统计学分析。结果慢阻肺合并肺栓塞组患者D-二聚体、NLR和PLR水平高于慢阻肺组及健康对照组,且慢阻肺组高于健康对照组;慢阻肺合并肺栓塞患者中3项指标高危组和中危组高于低危组,且中危组高于低危组,差异均有统计学意义(P<0.05)。ROC曲线显示,D-二聚体、NLR、PLR以及三者联合诊断慢阻肺合并肺栓塞曲线下面积(AUC)分别为0.875、0.950、0.810和0.971。结论D-二聚体、NLR和PLR在肺栓塞患者中升高,通过测定D-二聚体、NLR和PLR水平有助于慢阻肺合并肺栓塞的早期诊断及病情评估。 展开更多
关键词 D-二聚体 中性粒细胞/淋巴细胞比值 血小板/淋巴细胞比值 慢性阻塞性肺疾病 肺栓塞
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Proteomic analysis of differently expressed proteins in human hepatocellular carcinoma cell lines HepG2 with transfecting hepatitis B virus X gene 被引量:6
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作者 LI Wei-hua miao xiao-hui +3 位作者 QI Zhong-tian NI Wu ZHU Shi-ying FANG Fang 《Chinese Medical Journal》 SCIE CAS CSCD 2009年第1期15-23,共9页
Background Hepatitis B virus encoded X protein (HBx) is a trans-activating protein that may be involved in hepatocarcinogenesis, although few natural effectors of HBx that participate in this process have been ident... Background Hepatitis B virus encoded X protein (HBx) is a trans-activating protein that may be involved in hepatocarcinogenesis, although few natural effectors of HBx that participate in this process have been identified. We screened, by comparative proteomics method, effectors of HBx associated with hepatocarcinogenesis.Methods HBx positive and negative HepG2 cells were constructed and expression patterns of cellular proteins were obtained by high resolution, two dimensional electrophoresis. Comprehensive analyses of proteins associated with hepatocellular carcinoma (HCC) were focused on the differently expressed proteins (more than two-fold increase or decrease, P 〈0.05) from HBx positive and negative HepG2 cells. For peptide mass fingerprinting, protein spots with different intensity between HBx positive and negative HepG2 cells were directly cut out of gels and processed for matrix assisted, laser desorption/ionization, time of flight mass spectrometry and liquid chromatography-tandem mass spectrometry (LC-ESI-MS/MS) analysis.Results The mean number of protein spots for HBx negative and HBx positive HepG2 cells were 2095±137 and 2188±105, respectively. The analysis of paired cells showed 75 spots with significant differences in expression between HBx negative and HBx positive cells: 37 spots corresponding to 32 different proteins; 25 proteins were upregulated, 7 downregulated. We found 7 proteins not previously reported differentially expressed in HBx positive HepG2 cells. Variations in protein accumulation were confirmed for four (HSP90AB1, BCL2 associated athanogene 2. nucleophosmin and chloride intracellular channel 1) by Western blotting in HBx positive HepG2 cells.Conclusions Numerous effectors of HBx that may promote the development of HCC are identified, of which 7 are newly noted in HepG2 cells. Several of these effectors of HBx may help in elucidating the roles of HBx in hepatocarcinogenesis and diagnostics or targets for therapeutic intervention. 展开更多
关键词 hepatitis B virus x protein hepatocellular carcinoma hepatocellular carcinoma associated proteins PROTEOMICS
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Single-agent maintenance therapy in non-small cell lung cancer: a systematic review and meta-analysis 被引量:1
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作者 YUAN Dong-mei WEI Shu-zhen +6 位作者 LU Yan-ling ZHANG Yan miao xiao-hui ZHAN Ping YU Li-ke SHI Yi SONG Yong 《Chinese Medical Journal》 SCIE CAS CSCD 2012年第17期3143-3149,共7页
Background Can single-agent maintenance therapy be considered as an ideal strategy for non-small cell lung cancer (NSCLC) treatment to achieve prolonged survival and tolerated toxicity? A systematic review and meta... Background Can single-agent maintenance therapy be considered as an ideal strategy for non-small cell lung cancer (NSCLC) treatment to achieve prolonged survival and tolerated toxicity? A systematic review and meta-analysis was performed to etuc(date this issue. Methods The electronic databases were searched for RCTs comparing single-agent maintenance therapy with placebo, best support care or observation. The required data for estimation of response, survival and toxicity were extracted from the publications and the combined data were calculated. Results Eleven RCTs involving 3686 patients were identified. We found a statistically significant higher probability of tumor response for patients with maintenance therapy versus control patients (OR: 2.80, 95% CI: 2.15-3.64). Patients receiving maintenance therapy had significantly longer progression-free survival (PFS) (HR: 0.67, 95% CI: 0.62-0.71) and overall survival (OS) (HR: 0.84, 95% CI: 0.78-0.90). However, maintenance therapy was associated with more severe toxicities (OR: 6.45, 95% CI: 4.61-9.01). Conclusion In patients with advanced NSCLC, the use of single-agent maintenance therapy is associated with higher response rate and significantly prolongs PFS and OS despite of the risk of additional toxicity. 展开更多
关键词 non-small cell lung cancer maintenance therapy molecular targeted therapy systematic review META-ANALYSIS
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