为探究低温解除后苜蓿光合作用恢复过程中的限制位点,以‘新牧4号’和‘甘农5号’2个品种紫花苜蓿为材料,测定其低温胁迫及恢复过程中苜蓿叶片光合活性的变化。结果表明,低温胁迫下2个苜蓿品种叶片叶绿素含量、净光合速率以及光系统Ⅱ(p...为探究低温解除后苜蓿光合作用恢复过程中的限制位点,以‘新牧4号’和‘甘农5号’2个品种紫花苜蓿为材料,测定其低温胁迫及恢复过程中苜蓿叶片光合活性的变化。结果表明,低温胁迫下2个苜蓿品种叶片叶绿素含量、净光合速率以及光系统Ⅱ(photosystemⅡ,PSⅡ)活性显著下降,非光化学淬灭系数(nonphotochemical quenching factor,NPQ)显著上升,但对光系统Ⅰ(photosystemⅠ,PSⅠ)的活性无显著影响;其中,‘甘农5号’叶绿素对低温更敏感,含量下降较多。室温恢复72 h后,2个品种苜蓿叶片PSⅡ的活性及净光合速率都有上升但均未恢复至处理前水平;NPQ缓慢下降至处理前水平,‘甘农5号’NPQ较‘新牧4号’更高,表明在恢复过程中仍有过剩光能需通过NPQ消耗。苜蓿叶片的电子传递链在低温下受抑制显著,恢复72 h后PSⅡ受体侧活性基本恢复至处理前,而PSⅡ供体侧活性显著下降。2个品种苜蓿单位反应中心捕获的用于电子传递的能量(energy captured by unit reaction center for electron transfer,ETO/RC)和单位反应中心捕获的用于还原QA的能量(energy captured by the unit reaction center for reducing QA,TRO/RC)在低温处理72 h后显著下降,解除低温后恢复至处理前水平,且2个品种无显著差异;2个苜蓿品种单位反应中心耗散掉的能量(energy dissipated by the unit reaction center,DIO/RC)未恢复至处理前水平,且‘甘农5号’在恢复72 h后DIO/RC显著升高。综上,低温胁迫显著伤害紫花苜蓿叶片光合机构,降低了光合速率,光合速率未恢复到处理前与PSⅡ的活性显著相关,限制光合作用恢复的位点在其供体侧,非光化学淬灭是恢复24 h过剩光能的主要分配途径。展开更多
为获得一种绿色高效的羧甲基多孔淀粉制备工艺,本研究以酶解制得的多孔木薯淀粉为原料,氯乙酸钠为醚化剂,氢氧化钠为催化剂,采用机械活化协同固相醚化法制备羧甲基多孔淀粉,通过单因素实验探究各因素对羧甲基多孔淀粉取代度(Degree of s...为获得一种绿色高效的羧甲基多孔淀粉制备工艺,本研究以酶解制得的多孔木薯淀粉为原料,氯乙酸钠为醚化剂,氢氧化钠为催化剂,采用机械活化协同固相醚化法制备羧甲基多孔淀粉,通过单因素实验探究各因素对羧甲基多孔淀粉取代度(Degree of substitution,DS)的影响,并探讨羧甲基多孔淀粉在酱油中的应用。结果表明,机械活化协同固相法制备羧甲基多孔淀粉的最佳工艺条件为:多孔淀粉与氯乙酸钠的物质的量之比为1:1,氢氧化钠质量分数为18.8%,球磨时间1.5 h,反应温度50℃,此条件下制备得到的羧甲基多孔淀粉取代度最高为0.2532。通过红外光谱仪(Infrared spectrometer,FTIR)、X-射线粉末衍射仪(X-ray powder diffractometer,XRD)和扫描电镜(Scanning electron microscope,SEM)等表征,进一步证实多孔淀粉发生了羧甲基化反应。随着羧甲基多孔淀粉DS的增大其冷水溶解度、吸水率和柠檬黄吸附量增大;当DS为0.2532时,羧甲基多孔淀粉的冷水溶解度达到64.94%,吸水率达到180.73%,柠檬黄吸附量达到2.5086 mg·g^(-1)。羧甲基多孔淀粉所制备的粉末酱油相比于木薯淀粉和多孔淀粉所制备的粉末酱油溶解性更好,吸潮性更低,氨基酸态氮含量更高,与原酱油最接近。因此,机械活化协同固相醚化法可有效制备羧甲基多孔淀粉,该法操作简单,绿色环保,取代高,为多孔淀粉的开发利用提供了科学依据。展开更多
目的:系统评价地黄饮子加减及联合常规西药治疗痴呆的有效性。方法:计算机检索中国知网、中国生物医学文献数据库、万方数据库、维普数据库、PubMed、Web of science、Embase数据库中地黄饮子加减及联合常规西药治疗痴呆的随机对照试验...目的:系统评价地黄饮子加减及联合常规西药治疗痴呆的有效性。方法:计算机检索中国知网、中国生物医学文献数据库、万方数据库、维普数据库、PubMed、Web of science、Embase数据库中地黄饮子加减及联合常规西药治疗痴呆的随机对照试验,检索时间为各数据库建库至2023年9月。筛选符合纳入标准的文献进行质量评价,提取相应资料,采用RevMan5.3软件进行Meta分析。结果:共纳入文献21篇,1647例患者。Meta分析结果显示,治疗组的临床疗效高于对照组[OR=4.22,95%CI(3.22,5.52),P<0.00001],治疗组改善痴呆的MMSE评分高于对照组[MD=3.88,95%CI(1.98,5.77),P<0.0001],治疗组改善痴呆的HDS评分高于对照组[MD=3.86,95%CI(1.85,5.88),P<0.01],治疗组改善痴呆的ADL评分低于对照组[MD=-2.79,95%CI(-4.56,-1.02),P<0.01]。治疗组痴呆的不良反应发生率未明显低于对照组[OR=0.50,95%CI(0.25,0.99),P=0.05>0.01]。结论:地黄饮子加减及联合常规西药治疗痴呆的总有效率高于单纯常规西药治疗,且可改善简易精神状态检查量表(mini-mental state examination,MMSE)、长谷川痴呆量表(hastgawa dementia scale,HDS)和日常生活能力量表(activity of daily living scale,ADL)评分。本研究存在一定的局限性,仍需多中心、大样本、高质量的研究补充论证。展开更多
Additive manufacturing provides achievability for the fabrication of bimetallic and multi-material structures;however,the material compatibility and bondability directly affect the parts’formability and final quality...Additive manufacturing provides achievability for the fabrication of bimetallic and multi-material structures;however,the material compatibility and bondability directly affect the parts’formability and final quality.It is essential to understand the underlying printability of different material combinations based on an adapted process.Here,the printability disparities of two common and attractive material combinations(nickel-and iron-based alloys)are evaluated at the macro and micro levels via laser directed energy deposition(DED).The deposition processes were captured using in situ high-speed imaging,and the dissimilarities in melt pool features and track morphology were quantitatively investigated within specific process windows.Moreover,the microstructure diversity of the tracks and blocks processed with varied material pairs was comparatively elaborated and,complemented with the informative multi-physics modeling,the presented non-uniformity in mechanical properties(microhardness)among the heterogeneous material pairs was rationalized.The differences in melt flow induced by the unlike thermophysical properties of the material pairs and the resulting element intermixing and localized re-alloying during solidification dominate the presented dissimilarity in printability among the material combinations.This work provides an in-depth understanding of the phenomenological differences in the deposition of dissimilar materials and aims to guide more reliable DED forming of bimetallic parts.展开更多
The formation of low-resistance Ohmic contacts in Ga_(2)O_(3) is crucial for high-performance electronic devices. Conventionally, a titanium/gold(Ti/Au) electrode is rapidly annealed to achieve Ohmic contacts, resulti...The formation of low-resistance Ohmic contacts in Ga_(2)O_(3) is crucial for high-performance electronic devices. Conventionally, a titanium/gold(Ti/Au) electrode is rapidly annealed to achieve Ohmic contacts, resulting in mutual diffusion of atoms at the interface. However, the specific role of diffusing elements in Ohmic contact formation remains unclear.In this work, we investigate the contribution of oxygen atom diffusion to the formation of Ohmic contacts in Ga_(2)O_(3). We prepare a Ti/Au electrode on a single crystal substrate and conduct a series of electrical and structural characterizations.Using density functional theory, we construct a model of the interface and calculate the charge density, partial density of states, planar electrostatic potential energy, and I–V characteristics. Our results demonstrate that the oxygen atom diffusion effectively reduces the interface barrier, leading to low-resistance Ohmic contacts in Ga_(2)O_(3). These findings provide valuable insights into the underlying mechanisms of Ohmic contact formation and highlight the importance of considering the oxygen atom diffusion in the design of Ga_(2)O_(3)-based electronic devices.展开更多
We investigate the chiral edge states-induced Josephson current–phase relation in a graphene-based Josephson junction modulated by the off-resonant circularly polarized light and the staggered sublattice potential.By...We investigate the chiral edge states-induced Josephson current–phase relation in a graphene-based Josephson junction modulated by the off-resonant circularly polarized light and the staggered sublattice potential.By solving the Bogoliubov–de Gennes equation,a φ_(0) Josephson junction is induced in the coaction of the off-resonant circularly polarized light and the staggered sublattice potential,which arises from the fact that the center of-mass wave vector of Cooper pair becomes finite and the opposite center of-mass wave vector to compensate is lacking in the nonsuperconducting region.Interestingly,when the direction of polarization of light is changed,-φ_(0) to φ_(0) transition generates,which generalizes the concept of traditional 0–πtransition.Our findings provide a purely optical way to manipulate a phase-controllable Josephson device and guidelines for future experiments to confirm the presence of graphene-based φ_(0)Josephson junction.展开更多
Objective To investigate the efficacy of raw corn starch(RCS)in clinical management of insulinoma-induced hypoglycemia.Methods We retrospectively collected clinical data of insulinoma patients who received RCS-supplem...Objective To investigate the efficacy of raw corn starch(RCS)in clinical management of insulinoma-induced hypoglycemia.Methods We retrospectively collected clinical data of insulinoma patients who received RCS-supplemented diet preoperatively,and analyzed the therapeutic effects of the RCS intervention on blood glucose control,weight change,and its adverse events.Results The study population consisted of 24 cases of insulinoma patients,7 males and 17 females,aged 46.08±14.15 years.Before RCS-supplemented diet,all patients had frequent hypoglycemic episodes(2.51±3.88 times/week),concurrent with neuroglycopenia(in 83.3% of patients)and autonomic manifestations(in 75.0% of patients),with the median fasting blood glucose(FBG)of 2.70(interquartile range[IQR]:2.50-2.90)mmol/L.The patients'weight increased by 0.38(IQR:0.05-0.65)kg per month,with 8(33.3%)cases developing overweight and 7(29.2%)cases developing obesity.All patients maintained the RCS-supplemented diet until they underwent tumor resection(23 cases)and transarterial chemoembolization for liver metastases(1 case).For 19 patients receiving RCS throughout the day,the median FBG within one week of nutritional management was 4.30(IQR:3.30-5.70)mmol/L,which was a significant increase compared to pre-nutritional level[2.25(IQR:1.60-2.90)mmol/L;P<0.001].Of them,10 patients receiving RCS throughout the day for over four weeks had sustained improvement in FBG compared to pre-treatment[3.20(IQR:2.60-3.95)mmol/L vs.2.15(IQR:1.83-2.33)mmol/L;P<0.001].Five patients who received RCS only at night also had a significant increase in FBG within one week of nutritional management[3.50(IQR:2.50-3.65)mmol/L vs.2.20(IQR:1.80-2.60)mmol/L;P<0.001],but only one patient who continued to receive RCS for over four weeks did not have a significant improvement in FBG.No improvement in weight gain was observed upon RCS supplementation.Mild diarrhea(2 cases)and flatulence(1 case)occurred,and were relieved by reduction of RCS dose.Conclusion The RCS-supplemented diet is effective in controlling insulinoma-induced hypoglycemia.展开更多
BACKGROUND Gastric cancer has a high incidence and fatality rate,and surgery is the preferred course of treatment.Nonetheless,patient survival rates are still low,and the incidence of major postoperative complications...BACKGROUND Gastric cancer has a high incidence and fatality rate,and surgery is the preferred course of treatment.Nonetheless,patient survival rates are still low,and the incidence of major postoperative complications cannot be disregarded.The systemic inflammatory response,nutritional level,and coagulation status are key factors affecting the postoperative recovery and prognosis of gastric cancer patients.The systemic inflammatory response index(SIRI)and the albumin fibrinogen ratio(AFR)are two valuable comprehensive indicators of the severity and prognosis of systemic inflammation in various medical conditions.AIM To assess the clinical importance and prognostic significance of the SIRI scores and the AFR on early postoperative outcomes in patients undergoing radical gastric cancer surgery.METHODS We conducted a retrospective analysis of the clinicopathological characteristics and relevant laboratory indices of 568 gastric cancer patients from January 2018 to December 2019.We calculated and compared two indicators of inflammation and then examined the diagnostic ability of combined SIRI and AFR values for serious early postoperative complications.We scored the patients and categorized them into three groups based on their SIRI and AFR levels.COX analysis was used to compare the three groups of patients the prognostic value of various preoperative SIRI-AFR scores for 5-year overall survival(OS)and disease-free survival(DFS).RESULTS SIRI-AFR scores were an independent risk factor for prognosis[OS:P=0.004;hazards ratio(HR)=3.134;DFS:P<0.001;HR=3.543]and had the highest diagnostic power(area under the curve:0.779;95%confidence interval:0.737-0.820)for early serious complications in patients with gastric cancer.The tumor-node-metastasis stage(P=0.001),perioperative transfusion(P=0.044),positive carcinoembryonic antigen(P=0.014)findings,and major postoperative complications(P=0.011)were factors associated with prognosis.CONCLUSION Preoperative SIRI and AFR values were significantly associated with early postoperative survival and the occurrence of severe complications in gastric cancer patients.展开更多
Atherosclerosis(AS)is the main underlyingpathology of atherosclerotic cardiovascular disease(ASCVD),which is the leading cause of mortality inthe worldwide[1,2].Since the 19th century,Virchowhas already stated that AS...Atherosclerosis(AS)is the main underlyingpathology of atherosclerotic cardiovascular disease(ASCVD),which is the leading cause of mortality inthe worldwide[1,2].Since the 19th century,Virchowhas already stated that AS is a chronic inflammatorystate induced by cholesterol.After that,it took at leastthree decades’worth of study to establish the multipleinflammatory pathways related to AS.展开更多
文摘为探究低温解除后苜蓿光合作用恢复过程中的限制位点,以‘新牧4号’和‘甘农5号’2个品种紫花苜蓿为材料,测定其低温胁迫及恢复过程中苜蓿叶片光合活性的变化。结果表明,低温胁迫下2个苜蓿品种叶片叶绿素含量、净光合速率以及光系统Ⅱ(photosystemⅡ,PSⅡ)活性显著下降,非光化学淬灭系数(nonphotochemical quenching factor,NPQ)显著上升,但对光系统Ⅰ(photosystemⅠ,PSⅠ)的活性无显著影响;其中,‘甘农5号’叶绿素对低温更敏感,含量下降较多。室温恢复72 h后,2个品种苜蓿叶片PSⅡ的活性及净光合速率都有上升但均未恢复至处理前水平;NPQ缓慢下降至处理前水平,‘甘农5号’NPQ较‘新牧4号’更高,表明在恢复过程中仍有过剩光能需通过NPQ消耗。苜蓿叶片的电子传递链在低温下受抑制显著,恢复72 h后PSⅡ受体侧活性基本恢复至处理前,而PSⅡ供体侧活性显著下降。2个品种苜蓿单位反应中心捕获的用于电子传递的能量(energy captured by unit reaction center for electron transfer,ETO/RC)和单位反应中心捕获的用于还原QA的能量(energy captured by the unit reaction center for reducing QA,TRO/RC)在低温处理72 h后显著下降,解除低温后恢复至处理前水平,且2个品种无显著差异;2个苜蓿品种单位反应中心耗散掉的能量(energy dissipated by the unit reaction center,DIO/RC)未恢复至处理前水平,且‘甘农5号’在恢复72 h后DIO/RC显著升高。综上,低温胁迫显著伤害紫花苜蓿叶片光合机构,降低了光合速率,光合速率未恢复到处理前与PSⅡ的活性显著相关,限制光合作用恢复的位点在其供体侧,非光化学淬灭是恢复24 h过剩光能的主要分配途径。
文摘为获得一种绿色高效的羧甲基多孔淀粉制备工艺,本研究以酶解制得的多孔木薯淀粉为原料,氯乙酸钠为醚化剂,氢氧化钠为催化剂,采用机械活化协同固相醚化法制备羧甲基多孔淀粉,通过单因素实验探究各因素对羧甲基多孔淀粉取代度(Degree of substitution,DS)的影响,并探讨羧甲基多孔淀粉在酱油中的应用。结果表明,机械活化协同固相法制备羧甲基多孔淀粉的最佳工艺条件为:多孔淀粉与氯乙酸钠的物质的量之比为1:1,氢氧化钠质量分数为18.8%,球磨时间1.5 h,反应温度50℃,此条件下制备得到的羧甲基多孔淀粉取代度最高为0.2532。通过红外光谱仪(Infrared spectrometer,FTIR)、X-射线粉末衍射仪(X-ray powder diffractometer,XRD)和扫描电镜(Scanning electron microscope,SEM)等表征,进一步证实多孔淀粉发生了羧甲基化反应。随着羧甲基多孔淀粉DS的增大其冷水溶解度、吸水率和柠檬黄吸附量增大;当DS为0.2532时,羧甲基多孔淀粉的冷水溶解度达到64.94%,吸水率达到180.73%,柠檬黄吸附量达到2.5086 mg·g^(-1)。羧甲基多孔淀粉所制备的粉末酱油相比于木薯淀粉和多孔淀粉所制备的粉末酱油溶解性更好,吸潮性更低,氨基酸态氮含量更高,与原酱油最接近。因此,机械活化协同固相醚化法可有效制备羧甲基多孔淀粉,该法操作简单,绿色环保,取代高,为多孔淀粉的开发利用提供了科学依据。
文摘目的:系统评价地黄饮子加减及联合常规西药治疗痴呆的有效性。方法:计算机检索中国知网、中国生物医学文献数据库、万方数据库、维普数据库、PubMed、Web of science、Embase数据库中地黄饮子加减及联合常规西药治疗痴呆的随机对照试验,检索时间为各数据库建库至2023年9月。筛选符合纳入标准的文献进行质量评价,提取相应资料,采用RevMan5.3软件进行Meta分析。结果:共纳入文献21篇,1647例患者。Meta分析结果显示,治疗组的临床疗效高于对照组[OR=4.22,95%CI(3.22,5.52),P<0.00001],治疗组改善痴呆的MMSE评分高于对照组[MD=3.88,95%CI(1.98,5.77),P<0.0001],治疗组改善痴呆的HDS评分高于对照组[MD=3.86,95%CI(1.85,5.88),P<0.01],治疗组改善痴呆的ADL评分低于对照组[MD=-2.79,95%CI(-4.56,-1.02),P<0.01]。治疗组痴呆的不良反应发生率未明显低于对照组[OR=0.50,95%CI(0.25,0.99),P=0.05>0.01]。结论:地黄饮子加减及联合常规西药治疗痴呆的总有效率高于单纯常规西药治疗,且可改善简易精神状态检查量表(mini-mental state examination,MMSE)、长谷川痴呆量表(hastgawa dementia scale,HDS)和日常生活能力量表(activity of daily living scale,ADL)评分。本研究存在一定的局限性,仍需多中心、大样本、高质量的研究补充论证。
基金supported by the National Natural Science Foundation of China(51975112,52375412)Fundamental Research Funds for Central Universities(N2203011)。
文摘Additive manufacturing provides achievability for the fabrication of bimetallic and multi-material structures;however,the material compatibility and bondability directly affect the parts’formability and final quality.It is essential to understand the underlying printability of different material combinations based on an adapted process.Here,the printability disparities of two common and attractive material combinations(nickel-and iron-based alloys)are evaluated at the macro and micro levels via laser directed energy deposition(DED).The deposition processes were captured using in situ high-speed imaging,and the dissimilarities in melt pool features and track morphology were quantitatively investigated within specific process windows.Moreover,the microstructure diversity of the tracks and blocks processed with varied material pairs was comparatively elaborated and,complemented with the informative multi-physics modeling,the presented non-uniformity in mechanical properties(microhardness)among the heterogeneous material pairs was rationalized.The differences in melt flow induced by the unlike thermophysical properties of the material pairs and the resulting element intermixing and localized re-alloying during solidification dominate the presented dissimilarity in printability among the material combinations.This work provides an in-depth understanding of the phenomenological differences in the deposition of dissimilar materials and aims to guide more reliable DED forming of bimetallic parts.
基金Projects supported by the National Natural Science Foundation of China (Grant Nos.61874084,61974119,and U21A20501)。
文摘The formation of low-resistance Ohmic contacts in Ga_(2)O_(3) is crucial for high-performance electronic devices. Conventionally, a titanium/gold(Ti/Au) electrode is rapidly annealed to achieve Ohmic contacts, resulting in mutual diffusion of atoms at the interface. However, the specific role of diffusing elements in Ohmic contact formation remains unclear.In this work, we investigate the contribution of oxygen atom diffusion to the formation of Ohmic contacts in Ga_(2)O_(3). We prepare a Ti/Au electrode on a single crystal substrate and conduct a series of electrical and structural characterizations.Using density functional theory, we construct a model of the interface and calculate the charge density, partial density of states, planar electrostatic potential energy, and I–V characteristics. Our results demonstrate that the oxygen atom diffusion effectively reduces the interface barrier, leading to low-resistance Ohmic contacts in Ga_(2)O_(3). These findings provide valuable insights into the underlying mechanisms of Ohmic contact formation and highlight the importance of considering the oxygen atom diffusion in the design of Ga_(2)O_(3)-based electronic devices.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.12104232,11805103,and 11804167)the Natural Science Foundation of Jiangsu Province,China(Grant Nos.BK20190137 and BK20180739)+2 种基金the Fundamental Research Funds for the Central Universities(Grant Nos.020414380195 and B230201042)the Jit-b Project(Grant No.201831)the Natural Science Fund of Nanjing University of Posts and Telecommunications(Grant No.NY222163)。
文摘We investigate the chiral edge states-induced Josephson current–phase relation in a graphene-based Josephson junction modulated by the off-resonant circularly polarized light and the staggered sublattice potential.By solving the Bogoliubov–de Gennes equation,a φ_(0) Josephson junction is induced in the coaction of the off-resonant circularly polarized light and the staggered sublattice potential,which arises from the fact that the center of-mass wave vector of Cooper pair becomes finite and the opposite center of-mass wave vector to compensate is lacking in the nonsuperconducting region.Interestingly,when the direction of polarization of light is changed,-φ_(0) to φ_(0) transition generates,which generalizes the concept of traditional 0–πtransition.Our findings provide a purely optical way to manipulate a phase-controllable Josephson device and guidelines for future experiments to confirm the presence of graphene-based φ_(0)Josephson junction.
基金supported by the National High Level Hospital Clinical Research Fund(2022-PUMCH-A-146)the National Natural Science Foundation of China(72074222)the Na-tional Key Research and Development Program of China(2020YFC2005005).
文摘Objective To investigate the efficacy of raw corn starch(RCS)in clinical management of insulinoma-induced hypoglycemia.Methods We retrospectively collected clinical data of insulinoma patients who received RCS-supplemented diet preoperatively,and analyzed the therapeutic effects of the RCS intervention on blood glucose control,weight change,and its adverse events.Results The study population consisted of 24 cases of insulinoma patients,7 males and 17 females,aged 46.08±14.15 years.Before RCS-supplemented diet,all patients had frequent hypoglycemic episodes(2.51±3.88 times/week),concurrent with neuroglycopenia(in 83.3% of patients)and autonomic manifestations(in 75.0% of patients),with the median fasting blood glucose(FBG)of 2.70(interquartile range[IQR]:2.50-2.90)mmol/L.The patients'weight increased by 0.38(IQR:0.05-0.65)kg per month,with 8(33.3%)cases developing overweight and 7(29.2%)cases developing obesity.All patients maintained the RCS-supplemented diet until they underwent tumor resection(23 cases)and transarterial chemoembolization for liver metastases(1 case).For 19 patients receiving RCS throughout the day,the median FBG within one week of nutritional management was 4.30(IQR:3.30-5.70)mmol/L,which was a significant increase compared to pre-nutritional level[2.25(IQR:1.60-2.90)mmol/L;P<0.001].Of them,10 patients receiving RCS throughout the day for over four weeks had sustained improvement in FBG compared to pre-treatment[3.20(IQR:2.60-3.95)mmol/L vs.2.15(IQR:1.83-2.33)mmol/L;P<0.001].Five patients who received RCS only at night also had a significant increase in FBG within one week of nutritional management[3.50(IQR:2.50-3.65)mmol/L vs.2.20(IQR:1.80-2.60)mmol/L;P<0.001],but only one patient who continued to receive RCS for over four weeks did not have a significant improvement in FBG.No improvement in weight gain was observed upon RCS supplementation.Mild diarrhea(2 cases)and flatulence(1 case)occurred,and were relieved by reduction of RCS dose.Conclusion The RCS-supplemented diet is effective in controlling insulinoma-induced hypoglycemia.
基金the National Natural Science Foundation of China,No.8236110677Central to guide local scientific and Technological Development,No.ZYYDDFFZZJ-1+1 种基金Natural Science Foundation of Gansu Province,China,No.18JR2RA033Gansu Da Vinci Robot High-End Diagnosis and Treatment Team Construction Project,National Key Research and Development Program,No.2020RCXM076.
文摘BACKGROUND Gastric cancer has a high incidence and fatality rate,and surgery is the preferred course of treatment.Nonetheless,patient survival rates are still low,and the incidence of major postoperative complications cannot be disregarded.The systemic inflammatory response,nutritional level,and coagulation status are key factors affecting the postoperative recovery and prognosis of gastric cancer patients.The systemic inflammatory response index(SIRI)and the albumin fibrinogen ratio(AFR)are two valuable comprehensive indicators of the severity and prognosis of systemic inflammation in various medical conditions.AIM To assess the clinical importance and prognostic significance of the SIRI scores and the AFR on early postoperative outcomes in patients undergoing radical gastric cancer surgery.METHODS We conducted a retrospective analysis of the clinicopathological characteristics and relevant laboratory indices of 568 gastric cancer patients from January 2018 to December 2019.We calculated and compared two indicators of inflammation and then examined the diagnostic ability of combined SIRI and AFR values for serious early postoperative complications.We scored the patients and categorized them into three groups based on their SIRI and AFR levels.COX analysis was used to compare the three groups of patients the prognostic value of various preoperative SIRI-AFR scores for 5-year overall survival(OS)and disease-free survival(DFS).RESULTS SIRI-AFR scores were an independent risk factor for prognosis[OS:P=0.004;hazards ratio(HR)=3.134;DFS:P<0.001;HR=3.543]and had the highest diagnostic power(area under the curve:0.779;95%confidence interval:0.737-0.820)for early serious complications in patients with gastric cancer.The tumor-node-metastasis stage(P=0.001),perioperative transfusion(P=0.044),positive carcinoembryonic antigen(P=0.014)findings,and major postoperative complications(P=0.011)were factors associated with prognosis.CONCLUSION Preoperative SIRI and AFR values were significantly associated with early postoperative survival and the occurrence of severe complications in gastric cancer patients.
文摘Atherosclerosis(AS)is the main underlyingpathology of atherosclerotic cardiovascular disease(ASCVD),which is the leading cause of mortality inthe worldwide[1,2].Since the 19th century,Virchowhas already stated that AS is a chronic inflammatorystate induced by cholesterol.After that,it took at leastthree decades’worth of study to establish the multipleinflammatory pathways related to AS.