1∶2000到1∶10000数字线划图缩编技术研究

以1∶2000数字线划图缩编1∶10000数字线划图为例,结合项目生产实际,制定了数字线划图缩编的技术路线,并针对生产流程中各环节的重点问题探索了相应的自动化处理方法。在数据预处理阶段建立了数据转换模型,可实现生产底图的自动匹配与转换;在生产阶段定制了基于通用性缩编要求的缩编规则库,构建了自动化缩编批处理场景,并针对居民地、交通、水系、植被等要素缩编的特殊处理要求,开发了相应的缩编工具作为有效补充。针对自动缩编导致的要素拓扑关系错误,以狭长地带归并为例,设计了相应的分割与合并算法,并基于ArcGIS搭建了数据批处理模型,实现了自动化处理。以流程化批处理辅以定制缩编工具结合人机交互的方式进行数字线划图缩编可大幅提高生产效率,保障数据质量,为数字线划图缩编相关工作提供参考。

基于InSAR的武汉地区2016—2021年地面沉降监测

利用2016年1月—2021年12月的89景哨兵一号雷达影像,采用相干点目标分析合成孔径雷达干涉测量技术(IPTA-In⁃SAR)进行数据处理,获取了武汉地区的地面沉降信息,并联合GNSS基准站观测成果对InSAR监测的形变进行分析。结果表明2016—2021年期间,武汉市主城区形成了汉口、沙湖北和白沙洲3个较为明显的沉降中心,地面沉降呈连片化发展趋势。汉口地区的地面沉降速率最高,部分区域沉降超过10 mm/a,典型沉降区的地面沉降过程伴随有一定的波动特征,其中下沉趋势在不同年间会有区别,2016—2020年间特征点缓慢下沉,2018年开始加速下沉,至2020年下沉速度再次放缓。GNSS与InSAR特征点沉降分析表明2种技术的监测结果整体上具有很好的一致性。

学术期刊与新媒体融合构建学术生态圈

基于新媒体融合背景,分析了中文学术期刊影响力的发展现状。我国新媒体发展分为三个阶段:网络新媒体时代(1996—2008)、移动社交新媒体时代(2009—2018)、智慧新媒体时代(2019至今)。以广东省学术期刊公众号为例,分析了学术期刊新媒体发展中存在的共性问题。提出新媒体时代学术期刊影响力的提升策略:精准定位受众,打造期刊学术IP品牌;策划优质内容,积累期刊“私域流量”;建设学术社群,发展期刊“学术生态圈”。

Pt-Ni core-shell structure with Pt-skin and electronic effect on catalytic performance

In order to improve the catalytic performance of the nitrobenzene hydrogenation rearrangement to prepare p-aminophenol,a bimetallic Pt-Ni/C(PNC)catalyst was synthesized.Taking advantage of the synergistic effect of Ni and Pt to enhance product selectivity and catalytic performance stability,the electrons in Ni are moved to Pt by the electron effect,which affects the catalyst’s ability to activate H_(2)as well as the amount of hydrogen activated.Furthermore,due to the strong Pt(5d)-Ni(3d)coupling effect,Ni can effectively maintain Pt stability in the acidic system and reduce Pt dissolution.The stability of the PNC can be found to be greatly enhanced compared to the Pt/C(PC)catalyst,and p-aminophenol selectivity is greatly enhanced,showing excellent catalytic performance.

热风炉烟气温度广义预测控制器的设计与实现

某钢铁厂顶燃式热风炉升温过程具有滞后、时变和非线性的特点,现场热风炉烟气温度控制自动化程度低、控制品质差。为此,通过带遗忘因子的递推最小二乘法在线辨识时变模型参数,设计烟气温度升温过程的广义预测控制器。仿真和投运结果表明:控制效果良好,热风温度提高了3~5℃,同时节省了1.5%左右的煤气流量。

东革阿里多糖对红细胞氧化溶血的保护作用

采用超声结合水提的方法提取东革阿里的多糖,通过L9(34)正交试验确定最佳提取条件。利用柱层析纯化得到一种含糖醛酸的新型多糖组分Ali-1;通过分子量检测和单糖组成分析对Ali-1进行基本结构表征;采用氧自由基吸收能力(ORAC)和人血红细胞溶血模型测定多糖的抗氧化活性,并同时测定红细胞内活性氧物质(ROS)、丙二醛(MDA)水平和过氧化氢酶(CAT)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)抗氧化酶活力的变化。结果表明:东革阿里多糖最佳提取条件为料液比1:40、浸提温度95℃、超声波破碎功率300W、浸提时间2h,最适条件下东革阿里的粗多糖得率为10.09%;Ali-1的平均分子量为14.3ku,主要由木糖、阿拉伯糖、葡萄糖醛酸和半乳糖醛酸组成,其摩尔比为:4.43:1.10:1:1.14;Ali-1的QRAC值为302.48±2.71μmol Trolox/g,且Ali-1的预处理使得AAPH损伤的人血红细胞内的ROS和MDA水平降低,使红细胞恢复到正常状态;虽SOD、GSH-Px和CAT平均酶活力降低,但结果表明较弱的红细胞也受到了保护。综上所述,经分离纯化后的东革阿里多糖组分Ali-1可以保护人血红细胞免受AAPH的损伤,具有较好的抗氧化活性。

自然资源调查监测中的地理国情监测分类研究

在自然资源调查监测体系的框架下,地理国情监测工作需要分析自然资源本底数据,并结合自然资源"两统一"职责,制定可行的分类标准。通过分析基础调查的分类标准,研究了现有地理国情监测的分类体系,提出了新的分类构想,以期更好地与自然资源调查工作衔接、与前期地理国情监测工作衔接,为开展各项自然资源工作提供基础支撑。

Antioxidant and Anti-inflammatory Capacity of Ferulic Acid Released from Wheat Bran by Solid-state Fermentation of Aspergillus niger

Objective A strain of Aspergillus niger(A. niger), capable of releasing bound phenolic acids from wheat bran, was isolated. This strain was identified by gene sequence identification. The antioxidant and anti-inflammatory capacity of ferulic acid released from wheat bran by this A. niger strain(FA-WB) were evaluated. Methods Molecular identification techniques based on PCR analysis of specific genomic sequences were conducted; antioxidant ability was examined using oxygen radical absorbance capacity(ORAC), cellular antioxidant activity(CAA) assays, and erythrocyte hemolysis assays. RAW264.7 cells were used as a model to detect anti-inflammatory activity. Results The filamentous fungal isolate was identified to be A. niger. ORAC and CAA assay showed that FA-WB had better antioxidant activity than that of the ferulic acid standard. The erythrocyte hemolysis assay results suggested that FA-WB could attenuate AAPH-induced oxidative stress through inhibition of reactive oxy gen species(ROS) generation. FA-WB could significantly restore the AAPH-induced increase in intracellular antioxidant enzyme activities to normal levels as well as inhibit the intracellular malondialdehyde formation. TNF-?, IL-6, and NO levels indicated that FA-WB can inhibit the inflammation induced by lipopolysaccharide(LPS). Conclusion Ferulic acid released from wheat bran by a new strain of A. niger had good anti-inflammatory activity and better antioxidant ability than standard ferulic acid.

不同屈光度近视青少年儿童黄斑区血管密度和视网膜厚度的比较

目的:通过光学相干断层扫描血管成像技术(OCTA)观察与比较不同屈光度近视青少年儿童黄斑区血管密度和视网膜厚度的变化,并探讨其相关性。方法:前瞻性横断面研究。纳入6~18岁青少年儿童115例230眼。根据等效球镜度数(SE)分为4组:正视组16例32眼,低度近视组47例94眼,中度近视组34例68眼,高度近视组18例36眼。RTVueXR扫描黄斑区6mm×6mm范围,系统自动分区,分为以黄斑中心小凹为中心,直径分别为1mm的中心凹(fovea)环、1~3mm的内环(parafovea)、3~6mm的外环(perifovea),且每个圆环被进一步划分为颞(T)、上(S)、鼻(N)、下(I)4个象限,定量分析各分区浅层、深层毛细血管密度和视网膜厚度。结果:正视、低度、中度和高度近视组黄斑区整体浅层毛细血管密度依次显著减低,分别为(44.4±3.5)%、(44.8±3.8)%、(44.3±3.8)%、(42.6±4.5)%(F=2.963,P=0.033),内环颞侧浅层毛细血管密度分别为(46.1±3.5)%、(46.8±5.1)%、(46.2±4.3)%、(43.8±5.5)%(F=3.436,P=0.018);四组黄斑区整体深层毛细血管密度随着近视度数增加亦显著降低,分别为(49.9±4.1)%、(48.4±4.7)%、(47.9±5.5)%、(45.3±4.7)%(F=4.806,P=0.003),外环深层毛细血管密度分别为(49±4.4)%、(47.2±5.2)%、(46.6±6)%、(43.6±5.1)%(F=5.495,P=0.001)。四组黄斑区整体视网膜厚度分别为293.9±12.9、295.5±13.0、290.9±12.0、284.5±10.7μm(F=6.606,P<0.001)。内环颞侧、鼻侧浅层毛细血管密度与SE呈正相关(r=0.221、0.219,P=0.001、0.001),外环颞侧、上方、鼻侧、下方深层毛细血管密度与SE呈正相关(r=0.172、0.200、0.250、0.296,P=0.011、0.003、<0.001、<0.001);黄斑区除中心凹外其余区域视网膜厚度与SE均呈正相关(P<0.05)。结论:随着青少年儿童近视度数的增加,黄斑区浅层毛细血管密度降低,以内环颞侧为甚;深层毛细血管密度降低,以外环范围内为甚;视网膜厚度降低,以内环和外环范围为甚。青少年儿童近视随着屈光度增加,会导致黄斑区结构和血流循环的变化,在高度近视眼中改变尤为显著。

25G微创玻璃体切除术治疗眼内异物的疗效及术后视力的影响因素分析

目的:探讨经25G微创玻璃体切除手术(PPV)治疗的眼内异物的临床特征及疗效,分析术后视力的影响因素。方法:收集西南医科大学附属医院眼科2016-01-01/2019-01-01以眼内异物并行25G微创玻璃体切除手术治疗的患者105例105眼,对患者眼内异物的临床特征、PPV的疗效和最佳矫正视力(BCVA)等情况进行回顾性研究并统计分析术后视力的影响因素。结果:患者105例中以中青年男性居多,多来自于乡镇。异物类型以金属常见,共计62眼(59.0%),主要由Ⅰ区进入眼内(78眼,74.3%)。术中异物取出率100%。术前BCVA≥0.1的患者17眼,BCVA<0.1者88眼;术后BCVA≥0.1患者43眼,BCVA<0.1患者62眼,术后BCVA较术前BCVA有提高(P<0.05)。经多因素Logistic回归分析,术前较差的BCVA、视网膜脱离和眼内炎是术后视力较差的独立危险因素。结论:25G微创玻璃体切除手术可以改善大多数眼内异物患者视力。术前较差的BCVA、合并视网膜脱离和眼内炎是术后视力较差的重要危险因素。

Short-term Outcomes of Laparoscopic vs.Open Hepatectomy for Primary Hepatocellular Carcinoma:A Prospective Comparative Study

Laparoscopic hepatectomy(LH)is a newly developed technique associated with advantages as open surgery,but the study on outcome of liver function recovery was scarce.This preliminary report was aimed to comparatively assess the short?term outcomes between LH and open hepatectomy(OH)for primary hepatocellular carcinoma(PHC).This study retrospectively analyzed the demographic data and short-term outcomes of 81 patients who underwent LH or OH for the primary treatment of PHC between Oct.2017 and May 2018 at Union Hospital,Tongji Medical College,Huazhong University of Science and Technology(China).A total of 81 PHC patients who received major liver resection were enrolled.There were 38(47%)patients in the LH group and 43(53%)patients in the OH group.The operative time was significantly longer(373.53±173.38 vs.225.43±55.08,P<0.01),and hospital stay(17.34±5.93 vs.21.70±6.89,P=0.003),exhaust time(2.32±0.62 vs.3.07±0.59,P<0.01)and defecation time(2.92±0.78 vs.3.63±0.58,P<0.01)were significantly shorter in LH group than in OH group.The recovery of liver function was significantly faster in LH group,including higher serum albumin(P=0.002),higher ratio of albumin/globulin(P=0.029)and lower direct bilirubin(P=0.001)than in OH group.It is suggested that LH can serve as a fast recovery and cheap surgical procedure in the treatment of PHC,which is safe and feasible.

Identification and validation of tumor microenvironment-related lnc RNA prognostic signature for uveal melanoma

AIM:To investigate the role of tumor microenvironment(TME)-related long non-coding RNA(lncRNA)in uveal melanoma(UM),probable prognostic signature and potential small molecule drugs using bioinformatics analysis.METHODS:UM expression profile data were downloaded from the Cancer Genome Atlas(TCGA)and bioinformatics methods were used to find prognostic lncRNAs related to UM immune cell infiltration.The gene expression profile data of 80 TCGA specimens were analyzed using the single sample Gene Set Enrichment Analysis(ss GSEA)method,and the immune cell infiltration of a single specimen was evaluated.Finally,the specimens were divided into high and low infiltration groups.The differential expression between the two groups was analyzed using the R package‘edge R’.Univariate,multivariate and Least Absolute Shrinkage and Selection Operator(LASSO)Cox regression analyses were performed to explore the prognostic value of TMErelated lncRNAs.Gene Ontology and Kyoto Encyclopedia of Genes and Genomes(KEGG)functional analyses were also performed.The Connectivity Map(CMap)data set was used to screen molecular drugs that may treat UM.RESULTS:A total of 2393 differentially expressed genes were identified and met the criteria for the low and high immune cell infiltration groups.Univariate Cox analysis of lncRNA genes with differential expression identified 186 genes associated with prognosis.Eight prognostic markers of TME-included lncRNA genes were established as potentially independent prognostic elements.Among 269 differentially expressed lncRNAs,69 were up-regulated and 200 were down-regulated.Univariate Cox regression analysis of the risk indicators and clinical characteristics of the 8 lncRNA gene constructs showed that age,TNM stage,tumor base diameter,and low and high risk indices had significant prognostic value.We screened the potential small-molecule drugs for UM,including W-13,AH-6809 and Imatinib.CONCLUSION:The prognostic markers identified in this study are reliable biomarkers of UM.This study expands our current understanding of the role of TME-related lncRNAs in UM genesis,which may lay the foundations for future treatment of this disease.

Diagnosis and treatment of acute graft-versus-host disease after liver transplantation:Report of six cases

BACKGROUND Graft-versus-host disease(GVHD)following liver transplantation(LT)is an unpredictable complication with poor outcome.However,consensus regarding the diagnosis and therapeutic regimen for the disease is yet lacking.The present study summarized the clinical experience on the diagnosis and treatment of acute GVHD(aGVHD)following LT and reviewed the pertinent literature.CASE SUMMARY Between January 1^(st),2000 and December 31^(st),2020,a total of 1053 LT were performed in the First Affiliated Hospital of Xi’an Jiaotong University.Six recipients developed aGVHD with clinical symptoms of fever,rash,diarrhea,and pancytopenia.The incidence of aGVHD was 0.57%.The median time from LT to the clinical presentation of aGVHD was 22.17 d.The median time from the beginning of the clinical symptom to histopathological diagnosis was 7.5 d.All six cases underwent treatment of immunosuppressant adjustment,corticosteroids,human normal immunoglobulin,and antithymocyte globulin/IL-2 antagonists.Despite intensive treatment strategies,4 patients were deceased due to sepsis,multiple organ failure,and cerebral hemorrhage.The remaining two cases were discharged as treatment successfully.However,one died because of tuberculosis infection on the 6 th month of follow-up,the other one was alive healthy during 30 mo of follow-up.CONCLUSION The rapid diagnosis of aGVHD is mainly based on the time from the first symptom,histopathological features,and the donor T-lymphocyte chimerism.Our cases report highlights massive corticosteroid therapy and age difference between donors and recipients could accelerate to aGVHD.Moreover,gut microbial interventions and donor-targeted serotherapy may provide novel therapeutics.

Warm ischemia time and elevated serum uric acid are associated with metabolic syndrome after liver transplantation with donation after cardiac death

AIM To describe the prevalence of posttransplant metabolic syndrome(PTMS) after donation after cardiac death(DCD) liver transplantation(LT) and the pre-and postoperative risk factors.METHODS One hundred and forty-seven subjects who underwent DCD LT from January 2012 to February 2016 were enrolled in this study. The demographics and the clinical characteristics of pre-and post-transplantation were collected for both recipients and donors. PTMS was defined according to the 2004 Adult Treatment Panel-Ⅲ criteria. All subjects were followed monthly for the initial 6 mo after discharge, and then, every 3 mo for 2 years. The subjects were followed every 6 mo or as required after 2 years post-LT.RESULTS The prevalence of PTMS after DCD donor orthotopic LT was 20/147(13.6%). Recipient's body mass index(P = 0.024), warm ischemia time(WIT)(P = 0.045), and posttransplant hyperuricemia(P = 0.001) were significantly associated with PTMS. The change in serum uric acid levels in PTMS patients was significantly higher than that in non-PTMS patients(P < 0.001). After the 1 s t mo, the level of serum uric acid of PTMS patients rose continually over a period, while it was unaltered in non-PTMS patients. After transplantation, the level of serum uric acid in PTMS patients was not associated with renal function.CONCLUSION PTMS could occur at early stage after DCD LT with growing morbidity with the passage of time. WIT and post-LT hyperuricemia are associated with the prevalence of PTMS. An increased serum uric acid level is highly associated with PTMS and could act as a serum marker in this disease.

省级卫星中心遥感数据管理服务平台建设实践

以省级卫星中心遥感数据综合管理服务平台建设为例,设计了基于Web服务器、PostgreSQL数据库、C/S架构、B/S架构等技术的遥感数据管理方法。通过建设实践解决大规模遥感数据和信息产品共享中的多项关键技术,消除了目前空间数据分散和信息孤岛现象,提高了遥感数据查询、获取的准确性和时效性,实现了信息资源共享和高效服务。省级遥感数据管理服务平台的构建,为自然资源管理部门及社会公众提供了及时有效的动态监测信息和科学决策,可进一步推广应用在市县卫星应用技术中心节点的建设中。

赣州市两所学校初中生社会支持现状调查

目的:了解赣州市两所学校初中生社会支持的基本现状,为帮助开展初中生健康教育提供理论依据。方法:采用整群抽样方法抽取赣州市两所中学,共抽取初中生3 803名,使用《社会支持评定量表》对初中生进行匿名问卷调查,用以评定初中生社会支持现状。结果:初中生的社会支持总得分为36.10±7.13;其中,客观支持得分为7.56±2.18;主观支持得分为21.06±4.39;对社会支持的利用度得分为7.48±2.37。男生客观支持得分低于女生;农村初中生客观支持、支持利用度和支持总评分均低于乡镇初中生。多因素分析结果显示,母亲文化程度、主要使用的网络功能为学习知识及在网上常做帮助学习的事情、因为逃避现实或压力而喜欢上网等因素在不同程度上影响着初中生的社会支持状况。结论:初中生社会支持偏低,初中生社会支持各维度存在差异,学校在教育和管理过程中,应加大对初中生社会支持的关注,并采取一些针对性的方法改善和提高初中生的社会支持。

Efficacy and safety of sirolimus early conversion protocol in liver transplant patients with hepatocellular carcinoma:A single-arm, multicenter, prospective study

Mammalian target of rapamycin(m TOR) inhibitor as an attractive drug target with promising antitumor effects has been widely investigated. High quality clinical trial has been conducted in liver transplant(LT) recipients in Western countries. However, the pertinent studies in Eastern world are paucity. Therefore, we designed a clinical trial to test whether sirolimus can improve recurrence-free survival(RFS) in hepatocellular carcinoma(HCC) patients beyond the Milan criteria after LT. This is an open-labeled, single-arm, prospective, multicenter, and real-world study aiming to evaluate the clinical outcomes of early switch to sirolimus-based regimens in HCC patients after LT. Patients with a histologically proven HCC and beyond the Milan criteria will be enrolled. The initial immunosuppressant regimens are center-specifc for the frst 4-6 weeks. The following regimens integrated sirolimus into the regimens as a combination therapy with reduced calcineurin inhibitors based on the condition of patients and centers. The study is planned for 4 years in total with a 2-year enrollment period and a 2-year follow-up. We predict that sirolimus conversion regimen will provide survival benefts for patients particular in the key indicator RFS as well as better quality of life. If the trial is conducted successfully, we will have a continued monitoring over a longer follow-up time to estimate indicator of overall survival. We hope that the outcome will provide better evidence for clinical decision-making and revising treatment guidelines based on Chinese population data.

Application of evidence-based nursing intervention in patients with congenital heart diseases treated by transcatheter interventional therapy

Objective To explore the application of evidence-based nursing intervention in patients with congenital heart diseases treated by transcatheter interventional therapy.Methods A total of 64 patients with congenital heart diseases who were administered in our hospital from June 2011 to July 2013 were recruited in our research.

Uncatalyzed Condensation Reactions between Aromatic Aldehydes and Thiobarbituric Acid in Water

A series of 5-arylidene thiobarbituric acids were prepared from aromatic aldehydes and thiobarbituric acid in water without catalyst conditions in good yields. The structures were characterized by elemental analysis, IR and 1H NMR spectra.

Geographical Indication Protection and Brand Cultivation of Hefeng Tea in Wuling Mountain Area

Located in Wuling mountain area which is the main battlefield for poverty alleviation in the new stage,Hefeng County of Hubei Province has been recognized as a " National Key Tea-producing County in 2013"( ranking 17th) and one of the " Top Ten Ecological Rea Counties of China in 2012". As the first county of tea export in Hubei Province,it has been awarded the " Town of the Chinese Tea" certificate by the State Forestry Bureau. This paper introduced the characteristics of geographical indication and the current situation of brand of Hefeng Tea. Later,it analyzed its geographical indication protection and brand cultivation strategies and puts forward 9 suggestions.