Polarization optical imaging can be used to characterize anisotropy in biological tissue microstructures and has been demonstrated to be a powerful tool for clinical diagnosis. However, the approach is limited by an i...Polarization optical imaging can be used to characterize anisotropy in biological tissue microstructures and has been demonstrated to be a powerful tool for clinical diagnosis. However, the approach is limited by an inability to image targets deeper than ~1 mm due to strong optical scattering in biological tissues. As such, we propose a novel polarization microwave-induced thermoacoustic imaging(P-MTAI) technique to noninvasively detect variations in deep tissue by exploiting the thermoacoustic signals induced by four pulsed microwaves of varying polarization orientations. The proposed P-MTAI method overcomes the penetration limits of conventional polarization optical imaging and provides submillimeter resolution over depths of several centimeters. As part of the paper, the structural characteristics of tissues were quantified using a new parameter, the degree of microwave absorption anisotropy. P-MTAI was also applied to the noninvasive detection of morphological changes in cardiomyocytes as they transitioned from ordered to disordered states, providing a potential indication of myocardial infarction.展开更多
Background:Total mesorectum excision(TME)is considered the standard surgical procedure for rectal-cancer treatment.Transanal TME(taTME)is a new procedure to treat low rectal cancer.Some published studies have proven t...Background:Total mesorectum excision(TME)is considered the standard surgical procedure for rectal-cancer treatment.Transanal TME(taTME)is a new procedure to treat low rectal cancer.Some published studies have proven that taTME can provide a better-quality resected specimen in low-rectal-cancer patients in comparison to the transabdominal procedure,yet long-term outcomes must be investigated.We designed this non-inferiority trial(TaLaR trial)to compare short-term and long-term outcomes between taTME and laparoscopic TME(lapTME)for rectal cancer.Methods:The TaLaR trial is a phase III open-labeled multicenter randomized-controlled trial.Patients who are diagnosed with rectal cancer with no more than T3N2 stage,and with the tumor location below the peritoneal reflection by magnetic resonance imaging scan,digital rectal examination,or colonoscopy,qualify for this study.After calculating,a total of 1,114 patients(557 per group)will be randomly allocated to either the taTME or the lapTME group.Primary endpoints are the 3-year disease-free survival(DFS)rate and the 5-year overall survival(OS)rate.Secondary endpoints include specimen quality,perioperative results,pelvic and anal function,and quality of life.Discussion:The TaLaR trial is expected to clarify whether taTME can achieve comparable oncological outcomes,as well as improve specimen quality and recovery conditions in rectal-cancer patients compared with lapTME.展开更多
基金National Natural Science Foundation of China(62075066)Science and Technology Planning Project of Guangdong Province(2019A1515012054)Science and Technology Program of Guangzhou(2019050001).
文摘Polarization optical imaging can be used to characterize anisotropy in biological tissue microstructures and has been demonstrated to be a powerful tool for clinical diagnosis. However, the approach is limited by an inability to image targets deeper than ~1 mm due to strong optical scattering in biological tissues. As such, we propose a novel polarization microwave-induced thermoacoustic imaging(P-MTAI) technique to noninvasively detect variations in deep tissue by exploiting the thermoacoustic signals induced by four pulsed microwaves of varying polarization orientations. The proposed P-MTAI method overcomes the penetration limits of conventional polarization optical imaging and provides submillimeter resolution over depths of several centimeters. As part of the paper, the structural characteristics of tissues were quantified using a new parameter, the degree of microwave absorption anisotropy. P-MTAI was also applied to the noninvasive detection of morphological changes in cardiomyocytes as they transitioned from ordered to disordered states, providing a potential indication of myocardial infarction.
基金supported by a grant from Fundamental Research Funds for the Central Universities[Grant No.16ykjc25 addressed to L.K.]the Sun Yat-sen University Clinical Research 5010 Program[Grant No.2016005 addressed to L.K.].
文摘Background:Total mesorectum excision(TME)is considered the standard surgical procedure for rectal-cancer treatment.Transanal TME(taTME)is a new procedure to treat low rectal cancer.Some published studies have proven that taTME can provide a better-quality resected specimen in low-rectal-cancer patients in comparison to the transabdominal procedure,yet long-term outcomes must be investigated.We designed this non-inferiority trial(TaLaR trial)to compare short-term and long-term outcomes between taTME and laparoscopic TME(lapTME)for rectal cancer.Methods:The TaLaR trial is a phase III open-labeled multicenter randomized-controlled trial.Patients who are diagnosed with rectal cancer with no more than T3N2 stage,and with the tumor location below the peritoneal reflection by magnetic resonance imaging scan,digital rectal examination,or colonoscopy,qualify for this study.After calculating,a total of 1,114 patients(557 per group)will be randomly allocated to either the taTME or the lapTME group.Primary endpoints are the 3-year disease-free survival(DFS)rate and the 5-year overall survival(OS)rate.Secondary endpoints include specimen quality,perioperative results,pelvic and anal function,and quality of life.Discussion:The TaLaR trial is expected to clarify whether taTME can achieve comparable oncological outcomes,as well as improve specimen quality and recovery conditions in rectal-cancer patients compared with lapTME.
