Sepsis is a complex syndrome caused by multiple pathogens and involves multiple organ failure,particularly spleen dysfunction.In 2017,the worldwide incidence was 48.9 million sepsis cases and 1l million sepsis-related...Sepsis is a complex syndrome caused by multiple pathogens and involves multiple organ failure,particularly spleen dysfunction.In 2017,the worldwide incidence was 48.9 million sepsis cases and 1l million sepsis-related deaths were reported(Rudd et al.,2020).Inflammation,oxidative stress,and apoptosis are the most common pathologies seen in sepsis.Liensinine(LIE)is a bisbenzylisoquinoline-type alkaloid extracted from the seed embryo of Nelumbo nucifera.Lotus seed hearts have high content of LIE which mainly has antihypertensive and antiarrhythmic pharmacological effects.It can exert anti-carcinogenicactivityby regulating cell.展开更多
Pseudomonas aeruginosa belongs to the genus Pseudomonas and is a common Gram-negative,exclusively aerobic,conditionally pathogenic bacterium with the characteristics of easy colonization,mutation,and multidrug resista...Pseudomonas aeruginosa belongs to the genus Pseudomonas and is a common Gram-negative,exclusively aerobic,conditionally pathogenic bacterium with the characteristics of easy colonization,mutation,and multidrug resistance(Deng et al.,2015;Azam and Khan,2019;Jurado-Martin et al.,2021).展开更多
基金the National Natural Science Foundation of China(No.81773968)the Basic Science(Natural Science)Research Project of Higher Education of Jiangsu Province(No.21KJB230001)+1 种基金the Open-End Funds of Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening(No.HY202101)the Priority Academic Program Development of Jiangsu Higher Education Institutions of China。
文摘Sepsis is a complex syndrome caused by multiple pathogens and involves multiple organ failure,particularly spleen dysfunction.In 2017,the worldwide incidence was 48.9 million sepsis cases and 1l million sepsis-related deaths were reported(Rudd et al.,2020).Inflammation,oxidative stress,and apoptosis are the most common pathologies seen in sepsis.Liensinine(LIE)is a bisbenzylisoquinoline-type alkaloid extracted from the seed embryo of Nelumbo nucifera.Lotus seed hearts have high content of LIE which mainly has antihypertensive and antiarrhythmic pharmacological effects.It can exert anti-carcinogenicactivityby regulating cell.
基金supported by the Basic Science (Natural Science)Research Project of Higher Education of Jiangsu Province (No.21KJB230001)the Open-End Funds of Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening (No.HY202101)+3 种基金the Lianyungang City Science and Technology Bureau Science and Technology Plan (Social Development)Project (No.SF2140)the 2022 Medical Research guiding Project of Jiangsu Provincial Health Commission (No.Z2022070)the 2023 Jiangsu Graduate Research Innovation Plan Project (No.SJCX23_1838)the Priority Academic Program Development of Jiangsu Higher Education Institutions of China.
文摘Pseudomonas aeruginosa belongs to the genus Pseudomonas and is a common Gram-negative,exclusively aerobic,conditionally pathogenic bacterium with the characteristics of easy colonization,mutation,and multidrug resistance(Deng et al.,2015;Azam and Khan,2019;Jurado-Martin et al.,2021).
