Natural polyphenol has been widely believed to be effective in allergy remission. Currently, most of the natural poly- phenol products come from terrestrial sources such as tea, grape seeds among others, and few polyp...Natural polyphenol has been widely believed to be effective in allergy remission. Currently, most of the natural poly- phenol products come from terrestrial sources such as tea, grape seeds among others, and few polyphenols have been developed from algae for their anti-allergic activity. The aim of the study was to screen some commercial seaweed for natural extracts with anti-al- lergic activity. Five algae including Laminaria japonica, Porphyra sp., Spirulina platensis, Chlorella pyrenoidosa and Scytosiphon sp were extracted with ethanol, and the extracts were evaluated for total polyphenol contents and anti-allergic activity with the hyalu- ronidase inhibition assay. Results showed that the total polyphenol contents in the ethanol extracts ranged from 1.67% to 8.47%, while the highest was found in the extract from Scytosiphon sp. Hyaluronidase inhibition assay showed that the extracts from Scyto- siphon sp. had the lowest IC50, 0.67 mg mL-1, while Chlorella pyrenoidosa extract had the highest IC50, 15.07 mg mL-1. The anti-allergic activity of Scytosiphon sp. extract was even higher than the typical anti-allergic drug Disodium Cromoglycate （DSCG） （IC50=1.13 mg mL-1）, and was similar with natural polyphenol from Epigallocatechin gallate （EGCG） （IC50 = 0.56 mg mL-l）. These results indicated that the ethanol extract of Scytosiphon sp. contains a high concentration of polyphenol with high anti-allergic activ- ity. Potentially Scytosiphon sp. can be developed to a natural anti-allergic compound for allergy remission.展开更多
基金financially supported by Shandong Province Young and Middle-Aged Scientists Research Awards Fund(BS2011HZ020)the National Natural Science Foundation of China(No.31371730)Program for Changjiang Scholars and Innovative Research Team in University
文摘Natural polyphenol has been widely believed to be effective in allergy remission. Currently, most of the natural poly- phenol products come from terrestrial sources such as tea, grape seeds among others, and few polyphenols have been developed from algae for their anti-allergic activity. The aim of the study was to screen some commercial seaweed for natural extracts with anti-al- lergic activity. Five algae including Laminaria japonica, Porphyra sp., Spirulina platensis, Chlorella pyrenoidosa and Scytosiphon sp were extracted with ethanol, and the extracts were evaluated for total polyphenol contents and anti-allergic activity with the hyalu- ronidase inhibition assay. Results showed that the total polyphenol contents in the ethanol extracts ranged from 1.67% to 8.47%, while the highest was found in the extract from Scytosiphon sp. Hyaluronidase inhibition assay showed that the extracts from Scyto- siphon sp. had the lowest IC50, 0.67 mg mL-1, while Chlorella pyrenoidosa extract had the highest IC50, 15.07 mg mL-1. The anti-allergic activity of Scytosiphon sp. extract was even higher than the typical anti-allergic drug Disodium Cromoglycate （DSCG） （IC50=1.13 mg mL-1）, and was similar with natural polyphenol from Epigallocatechin gallate （EGCG） （IC50 = 0.56 mg mL-l）. These results indicated that the ethanol extract of Scytosiphon sp. contains a high concentration of polyphenol with high anti-allergic activ- ity. Potentially Scytosiphon sp. can be developed to a natural anti-allergic compound for allergy remission.
