It is estimated that chronic kidney disease(CKD)will be the fifth leading cause of death in the world by 2040[1].Early recognition and intervention for kidney damage are essential.Estimated glomerular filtration rate(...It is estimated that chronic kidney disease(CKD)will be the fifth leading cause of death in the world by 2040[1].Early recognition and intervention for kidney damage are essential.Estimated glomerular filtration rate(eGFR)can be calculated by measuring blood creatinine to evaluate glomerular function,and urinary N-acetyl-β-δ-glucosaminidase(UNAG)level is generally recognized as a marker of renal tubular injury.Exposure to lead(Pb)and cadmium(Cd)can damage renal function,leading to a decrease in eGFR and an increase in UNAG[2].Both Pb and Cd are easily accumulated in the body and then slowly released by the kidneys and excreted.So,urinary Pb(UPb)and Cd(UCd)levels can be used as biomarkers of exposure[3,4].展开更多
Hypertension is an increasingly prevalent chronic disease that affects approximately 1 billion people worldwide.Elevated blood pressure inflicts longterm damage to various organs,including the kidneys.Hypertension agg...Hypertension is an increasingly prevalent chronic disease that affects approximately 1 billion people worldwide.Elevated blood pressure inflicts longterm damage to various organs,including the kidneys.Hypertension aggravates the clinical course of chronic kidney disease,and promotes progression toward end-stage renal disease.Among the cases of end-stage renal disease,30%are directly attributable to hypertension.Though the molecular mechanism responsible for renal injury remains largely unknown,elucidating this mechanism is critical to preventing these deleterious complications.展开更多
基金supported by the National Natural Science Foundation of China[grant numbers 81872701,81273040]Shanxi Scholarship Council of China[grant number 2022-113].
文摘It is estimated that chronic kidney disease(CKD)will be the fifth leading cause of death in the world by 2040[1].Early recognition and intervention for kidney damage are essential.Estimated glomerular filtration rate(eGFR)can be calculated by measuring blood creatinine to evaluate glomerular function,and urinary N-acetyl-β-δ-glucosaminidase(UNAG)level is generally recognized as a marker of renal tubular injury.Exposure to lead(Pb)and cadmium(Cd)can damage renal function,leading to a decrease in eGFR and an increase in UNAG[2].Both Pb and Cd are easily accumulated in the body and then slowly released by the kidneys and excreted.So,urinary Pb(UPb)and Cd(UCd)levels can be used as biomarkers of exposure[3,4].
基金supported by a grant from the National Natural Science Foundation of China[No 81273040,81872701]grant from Shanxi graduate joint training base talent project[No 2016JD24]a research project of postgraduate education reform in Shanxi province[2018JG47]。
文摘Hypertension is an increasingly prevalent chronic disease that affects approximately 1 billion people worldwide.Elevated blood pressure inflicts longterm damage to various organs,including the kidneys.Hypertension aggravates the clinical course of chronic kidney disease,and promotes progression toward end-stage renal disease.Among the cases of end-stage renal disease,30%are directly attributable to hypertension.Though the molecular mechanism responsible for renal injury remains largely unknown,elucidating this mechanism is critical to preventing these deleterious complications.
