昼夜混合路径条件下低频天波传播特性的研究对导航授时系统中应用模式拓展及低电离层参数反演均具有重要的研究意义.本文以地—电离层中100 kHz载频罗兰-C信号的时域有限差分(Finite Difference Time Domain,FDTD)仿真为前提,基于传统...昼夜混合路径条件下低频天波传播特性的研究对导航授时系统中应用模式拓展及低电离层参数反演均具有重要的研究意义.本文以地—电离层中100 kHz载频罗兰-C信号的时域有限差分(Finite Difference Time Domain,FDTD)仿真为前提,基于传统的过零检测和快速傅里叶变换(Fast Fourier Transform,FFT)/逆快速傅里叶变换(Inverse Fast Fourier Transform,IFFT)频谱相除算法,对昼夜混合信道(传播路径为东西取向)中地面接收的一跳天波进行模式区分及特性分析.给出了在白天至夜晚、夜晚至白天两种突变电离层下罗兰-C一跳天波中不同模式随收发距离的变化规律,同时给出了模式干涉区域优势场量的分布情况.结果表明,对于昼夜混合模型,一跳天波中存在来自不同高度及昼夜突跳边界反射的多种模式,基于传统方法检测的幅度相位存在不稳定干涉效应,模式界定困难,而基于FFT/IFFT频谱相除算法能够将主要模式进行细化区分,从而获得更高精度、更平稳的模式特性.展开更多
Objective:To study the key target genes and signaling pathways in the treatment of Allergic Rhinitis(AR)with Radix Aconiti Lateralis Preparata(aka Fuzi).Methods:The TCMPS and PubChem databases were used to screen the ...Objective:To study the key target genes and signaling pathways in the treatment of Allergic Rhinitis(AR)with Radix Aconiti Lateralis Preparata(aka Fuzi).Methods:The TCMPS and PubChem databases were used to screen the active ingredients and target genes of Fuzi using oral bioavailability and drug similarity as screening conditions,and the GeneCards database was used to screen the target genes of AR.The online tool Venny2.1 was used to screen the target genes of Fuzi for the treatment of Allergic Rhinitis;the STRING database was used to obtain the protein-protein interaction(PPI)network of drug-disease targets,and the key target genes were identified by the MCC algorithm.The potential biological processes and signaling pathways were identified by GO enrichment and KEGG enrichment analysis.Finally,animal experiments were conducted to demonstrate the therapeutic effect ofFuzi on Allergic Rhinitis.Results:The TCMSP,PubChem and GeneCards databases were used to screen the 21 active compound components of Fuzi and 68 potential therapeutic target genes of Fuzi for Allergic Rhinitis.PPI network analysis identified the top ten key target genes,namely:PTGS2,TNF,IL6,AKT1,ALB,STAT3,CCL2,CXCL8,VEGFA and JUN,GO functional and KEGG pathway enrichment analysis showed that the significantly enriched functions and pathways of Fuzi on Allergic Rhinitis were closely related to Allergic Rhinitis.Finally,animal experiments were conducted to verify that Fuzi is effective in the treatment of Allergic rhinitis.Conclusion:Increased expression of IL-6 and TNF-αin nasal mucosal tissues of patients with Allergic Rhinitis was positively correlated with indicators related to the disease activity of AllergicRhinitis.Fuzi ameliorated the inflammatory changes in mice with Allergic Rhinitis by inhibiting the activation of Toll-like signaling pathway in the nasal mucosa and decreasing the expression activity of IL-6 and TNF-α.展开更多
文摘昼夜混合路径条件下低频天波传播特性的研究对导航授时系统中应用模式拓展及低电离层参数反演均具有重要的研究意义.本文以地—电离层中100 kHz载频罗兰-C信号的时域有限差分(Finite Difference Time Domain,FDTD)仿真为前提,基于传统的过零检测和快速傅里叶变换(Fast Fourier Transform,FFT)/逆快速傅里叶变换(Inverse Fast Fourier Transform,IFFT)频谱相除算法,对昼夜混合信道(传播路径为东西取向)中地面接收的一跳天波进行模式区分及特性分析.给出了在白天至夜晚、夜晚至白天两种突变电离层下罗兰-C一跳天波中不同模式随收发距离的变化规律,同时给出了模式干涉区域优势场量的分布情况.结果表明,对于昼夜混合模型,一跳天波中存在来自不同高度及昼夜突跳边界反射的多种模式,基于传统方法检测的幅度相位存在不稳定干涉效应,模式界定困难,而基于FFT/IFFT频谱相除算法能够将主要模式进行细化区分,从而获得更高精度、更平稳的模式特性.
基金Natural Science Foundation of Hainan Province(No.820RC627)。
文摘Objective:To study the key target genes and signaling pathways in the treatment of Allergic Rhinitis(AR)with Radix Aconiti Lateralis Preparata(aka Fuzi).Methods:The TCMPS and PubChem databases were used to screen the active ingredients and target genes of Fuzi using oral bioavailability and drug similarity as screening conditions,and the GeneCards database was used to screen the target genes of AR.The online tool Venny2.1 was used to screen the target genes of Fuzi for the treatment of Allergic Rhinitis;the STRING database was used to obtain the protein-protein interaction(PPI)network of drug-disease targets,and the key target genes were identified by the MCC algorithm.The potential biological processes and signaling pathways were identified by GO enrichment and KEGG enrichment analysis.Finally,animal experiments were conducted to demonstrate the therapeutic effect ofFuzi on Allergic Rhinitis.Results:The TCMSP,PubChem and GeneCards databases were used to screen the 21 active compound components of Fuzi and 68 potential therapeutic target genes of Fuzi for Allergic Rhinitis.PPI network analysis identified the top ten key target genes,namely:PTGS2,TNF,IL6,AKT1,ALB,STAT3,CCL2,CXCL8,VEGFA and JUN,GO functional and KEGG pathway enrichment analysis showed that the significantly enriched functions and pathways of Fuzi on Allergic Rhinitis were closely related to Allergic Rhinitis.Finally,animal experiments were conducted to verify that Fuzi is effective in the treatment of Allergic rhinitis.Conclusion:Increased expression of IL-6 and TNF-αin nasal mucosal tissues of patients with Allergic Rhinitis was positively correlated with indicators related to the disease activity of AllergicRhinitis.Fuzi ameliorated the inflammatory changes in mice with Allergic Rhinitis by inhibiting the activation of Toll-like signaling pathway in the nasal mucosa and decreasing the expression activity of IL-6 and TNF-α.