Evaluating therapeutic potential of coriander seeds and leaves(Coriandrum sativum L.) to mitigate carbon tetrachloride-induced hepatotoxicity in rabbits

Objective: To evaluate the hepatic and renal protective potential of coriander seeds and leaves using animal feed model. Methods: Coriander seeds-and leaves-based sauces were administrated to normal(Study Ⅰ) and carbon tetrachloride(2 mL/kg B.W.)-induced hepatotoxic rabbits(Study Ⅱ). Hepatic and renal biomarkers like aspartate aminotransferase,alanine aminotransferase. alkaline phosphatase, superoxide dismutase and catalase were measured. Results: Coriander leaves-based sauce exerted more decline(P<0.05) in serum aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase levels in the study Ⅱ as 18.32%. 19.91% and 21.24%, respectively. While, hepatic superoxide dismutase and catalase levels were raised significantly(P<0.05) in both studies. Renal parameters also depicted positive impact by the provision of developed sauces. Conclusions: Coriander seeds and leaves based sauces are effective in alleviating the hepato/renal toxicity. The hepatoprotective effect of coriander leaves is more pronounced as compared to coriander seeds.

Harmony,Stability,and Prosperity in Xinjiang

CHINA'S Xinjiang Uygur Autonomous Region is renowned for its gorgeous natural beauty,diversified ethnic customs,and rich culture.It is the largest provincial region in China covering an area of about 1.66 million square kilometers,roughly the size of Iran.It is home to 25.85million people,among which the Han ethnic group makes up 10.92 million,and ethnic minorities 14.93million,according to data from the seventh national census in 2020.

Chemiluminescent Determination of Cyromazine in Milk Samples Using Copper（III） Chelate-Triton X-100 by Flow Injection Analysis

Cyromazine（CYR） was determined in milk samples using copper（HI） chelate-Triton X-100 chemiluminescence（CL） system associated with flow-injection（FI） in KOH medium. The relative CL intensity for CYR concentration was linear over the range of 5×10^-4-10μg/mL（R2=0.9990, n=11） with injection rate of 160 h-1 and the relative standard deviation（RSD, n=4） of 1.2%-2.6%. The limit of detection（LOD） for signal-to-noise ratio of 3 was 1.5×10^4μg/mL. The influences of key chemical and physical parameters, some major fresh water ions at their maximum admissible concentrations and a number of pesticides were examined as potential interferences. The concentrations of CYR in spiked milk samples were successfully determined by the proposed method and the results were in good agreement with that of the previously reported HPLC method, having recovery range of （92% a=4%）-（106% a：2%）. The possible CL reaction mechanism for copper（m） chelate-Triton X-100-CYR was also briefly discussed.

Estimation of infiltration models parameters and their comparison to simulate the onsite soil infiltration characteristics

Detailed knowledge about soil characteristics and site-specific final steady infiltration rate could help to increase the irrigation water use efficiency and decrease water losses in agricultural system.The experiments were conducted on Agricultural Research Farm of Bahauddin Zakariya University,Multan,Pakistan during 2016.The cumulative infiltration depth was measured using double ring infiltrometer at selected six points of the study area.Most commonly used infiltration models such as Kostikov’s,Philip’s and Horton’s were fitted to the field infiltration data for determination of model parameters and to find the best fit model for the study area.Kostikov’s infiltration model’s parameters such as empirical constant‘c’and infiltration decay constants‘k’were obtained in the ranges of 0.140-0.290 and 0.307-0.433,respectively.Philip’s infiltration model’s parameters such as sorptivity‘S’and conductivity constant‘A’were found in the ranges of 0.167-0.288 cm/min1/2 and-0.001 to-0.009 cm/min,respectively.Similarly,the Horton’s model’s‘parameter‘k’was obtained in the range of-1.619 to-1.238.The value of infiltration capacity at onset of infiltration(fo)was obtained as 1.744 to 3.491 for all the six points.The analysis showed that the infiltration models using the estimated parameters have satisfactory prediction capability at all the selected points.Horton’s model provided the lowest mean values for RMSE(0.235)and highest mean values for ME(94%);and the lowest mean values for MPD(0.127).This indicated that infiltration can be well-described by the Horton’s model at the selected site.

Chemiluminescence Determination of Cefixime Trihydrate Based on Acidic Diperiodatoargentate(Ⅲ)-Rhodamine 6-G System

A novel chemiluminescence(CL) method is proposed for cefixime trihydrate(CFX) determination based on its eiiliancement effect on diperiodatoargentate(III)(DPA)-rhodamine 6-G(Rh6-G) reaction in conjunction with flow injection analysis(FIA). A linear calibration curve was achieved over the range from 0.01 mg/L to 2.5 mg/L CFX(R^2=0.999,n=8) with relative standard deviation(RSD) of 1.4%-3.8%(n=4)), limit of detection(LOD) of 3.0×10^-3 mg/L(S/N=3),injection tliroughput of 180/h and regression equation of y=1113.2x-14.596[y=CL intensity (mV) and x=concentration of CFX(mg/L)]. The method was successfully applied to CFX determination in pharmaceutical formulations and the recoveries(%) for proposed FI-CL and a reported spectrophotometric method by applying the Student t-test [calculated t-test value: t=1.079215, and tabulated t-distributed(95%)=2.200985] were not significantly diflerent. The CFX was efficiently extracted and no significant effect of commonly found excipients in the pharmaceutical formulations was observed. The mechanism of CL reaction is discussed briefly.

Flow Injection Chemiluminescence Method for Nalbuphine Hydrochloride in Pharmaceutical Formulations Using Tris(2,2′-bipyridyl)ruthenium(II)Chloride-diperiodatocuprate(III)Reaction

A sensitive and selective method employing chemiluminescence(CL)coupled with flow injection(FI)is reported for nalbuphine hydrochloride(NAL)assay in pharmaceutical formulations.The enhancement effect of NAL on the CL reaction between tris(2,2′-bipyridyl)ruthenium(II)chloride-diperiodatocuprate(III){Ru[(bpy)_(3)]^(2+)-Cu(III)complex}in acidic medium is used as analytical measurement.The optimal conditions of the CL reaction were sulfuric acid 1.0×10^(−3) mol/L,Ru[(bpy)s]2+7.5×10^(−5) mol/L,Cu(III)/Ag(III)complexes 4.0×10^(−4)/5.0×10^(−4) mol/L,sample loop volume of 120µL and flow rate of 2.5 mL/min.The sensitivities of the method in terms of detection(S/N=3)and quantification(S/N=10)limits are 5×10^(−4) and 0.001 ppm(1 ppm=1 mg/L),respectively.The linear response of the instrument in the form of CL intensity with respect to NAL concentration is over the range 0.001-15.0 ppm(R^(2)=0.9999)with relative standard deviation from 0.8%to 3.2%and injection throughput of 120 injection/h.The applications of the method include the quantitative analysis of NAL in pharmaceutical injection samples.Variations and the average results of the proposed method are not significantly different from the results of a reported method by applying F-and paired student t-test.The most likely CL reaction mechanism is written in accordance with spectrophotometric and CL studies.

Cascade-exciton model analysis of level density parameter dependence in proton induced fission cross sections of some sub-actinide nuclei

Fission cross sections strongly depend on the ratio of the level density parameter in fission to neutron emission, af/an . In this work, a cascade-exciton model implemented in the code CEM95 has been used to observe this effect for proton induced fission cross sections of tungsten, lead and bismuth. The method was employed using different level density parameter ratios for each fission cross section calculation. The calculated fission cross sections are compared with the available experimental data in the literature. It has been observed that a change of the ratio of the level density parameter, af/an , is necessary with the incident energy of the proton, to best estimate the fission cross sections in CEM95.

Palpable Prosperity

China’s Xinjiang Uygur Autonomous Region is renowned for its breathtaking natural beauty,wide-ranging ethnic customs,and abundant culture.It is China’s largest province-level region,covering an area of some 1.66 million square km—roughly the area of Iran.Home to 25.85 million people,the Han ethnic group accounts for 10.92 million and ethnic minorities for 14.93 million,according to data from the seventh national census in 2020.