Leaving ditches between adjacent mining areas can effectively reduce re-stripping in the latter mining area and simultaneously lead to an increment in internal dumping costs in the former mining area. This paper estab...Leaving ditches between adjacent mining areas can effectively reduce re-stripping in the latter mining area and simultaneously lead to an increment in internal dumping costs in the former mining area. This paper establishes calculation models for these two marginal costs. The optimizing model for slope cover height can be determined by including marginal cost models in the objective function. The paper has two main contributions:(a) it fully considers redistribution of dumping space in the model;(b) it introduces price fluctuations and cash discounts in the model. We use the typical open-pit mine as an example to test and prove the model. We conclude that a completely covered slope is reasonable in Haerwusu open pit mine; in addition to an increasing price index, the slope cover height can be reduced; and that price changes are one of the most important influencing factors of slope cover height optimization in an open-pit mine.展开更多
随着人们对肿瘤研究的深入,肿瘤疗法也越来越多元化,免疫疗法逐渐成为研究的热点。嵌合抗原受体T细胞疗法(chimeric antigen receptor T cell,CAR-T)是当今肿瘤治疗领域最具研究前景的方向之一,在血液瘤治疗方面取得了重大突破,但在实...随着人们对肿瘤研究的深入,肿瘤疗法也越来越多元化,免疫疗法逐渐成为研究的热点。嵌合抗原受体T细胞疗法(chimeric antigen receptor T cell,CAR-T)是当今肿瘤治疗领域最具研究前景的方向之一,在血液瘤治疗方面取得了重大突破,但在实体瘤中一直未有突破。本文就嵌合抗原受体T细胞疗法的结构发展历程和在实体瘤治疗中遇到的困难展开讨论。展开更多
基金the key project of the National Natural Science Foundation of China (No. 51034005)the Research Fund for the Doctoral Program of Higher Education of China(No.20100095110019)+1 种基金the National‘‘Twelfth Five-Year’’Plan for Science and Technology Support of China(No.2014BAC14B00)the National High Technology Research and Development Program of China(No.2012AA062004)
文摘Leaving ditches between adjacent mining areas can effectively reduce re-stripping in the latter mining area and simultaneously lead to an increment in internal dumping costs in the former mining area. This paper establishes calculation models for these two marginal costs. The optimizing model for slope cover height can be determined by including marginal cost models in the objective function. The paper has two main contributions:(a) it fully considers redistribution of dumping space in the model;(b) it introduces price fluctuations and cash discounts in the model. We use the typical open-pit mine as an example to test and prove the model. We conclude that a completely covered slope is reasonable in Haerwusu open pit mine; in addition to an increasing price index, the slope cover height can be reduced; and that price changes are one of the most important influencing factors of slope cover height optimization in an open-pit mine.
文摘随着人们对肿瘤研究的深入,肿瘤疗法也越来越多元化,免疫疗法逐渐成为研究的热点。嵌合抗原受体T细胞疗法(chimeric antigen receptor T cell,CAR-T)是当今肿瘤治疗领域最具研究前景的方向之一,在血液瘤治疗方面取得了重大突破,但在实体瘤中一直未有突破。本文就嵌合抗原受体T细胞疗法的结构发展历程和在实体瘤治疗中遇到的困难展开讨论。
