Clinical efficacy of external treatment with Zi Cao Yang He Tang combined with hormone therapy for granulomatous mastitis and its effect on cellular pyroptosis proteins

Objective:To observe the clinical effect of external application of Zi Cao Yang He Tang combined with dexamethasone ointment in the treatment of granulomatous lobular mastitis in the mass stage and the effect on cellular pyroptosis-related proteins.Methods:Forty patients with granulomatous lobular mastitis were randomly divided into 20 cases in the observation group and 20 cases in the control group.Both groups were given dexamethasone ointment for treatment,and the observation group was treated with external application of Zi Cao Yang He Tang on the basis of the control group.Breast lump vol-ume changes,breast pain and pus symptoms,pathology and histology and immunohistochemistry,cellular death-related indicators expression were compared between the two groups.Results:After treatment,the difference in mass volume of the observation group was significantly greater than that of the control group(16.7±21.5 in the control group and 32.9±27.4 in the experimental group)and the difference between the two groups was statistically significant(P<0.05);the objective remission rate of the patients in the observation group(ORR=85%)was significantly higher than that of the treatment group(ORR=50%,P<0.05).In terms of pus formation rate and pain level,the breast pain score of the observation group was significantly lower than that of the control group after two weeks or three weeks of treatment(P<0.05);the pus formation rate of the observation group was 30%,and the pus formation rate of the control group was 20%,and the difference was not statistically significant(P>0.05).The immunohistochemical expression levels of caspase-1 and GSDMD in the observation group were significantly lower than those in the control group(P<0.05);and in terms of the expression of cellular pyroptosis-related indexes,the expression of GSDMD,cas-pase-1,and NLRP3 in the observation group was significantly lower compared with that in the control group(P<0.05).Conclusion:The efficacy of external application of Zi Cao Yang He Tang combined with dexamethasone ointment in treating granulomatous lobular mastitis in the mass stage is remarkable,which can effectively reduce breast pain,reduce the size of the mass,de-crease the expression of cellular pyroptosisrelated indexes,and have a good anti-inflammatory effect.

Geochemical and Isotopic Techniques Constraints on the Origin,Evolution,and Residence Time of Low-enthalpy Geothermal Water in Western Wugongshan,SE China

Geothermal resources are increasingly gaining attention as a competitive,clean energy source to address the energy crisis and mitigate climate change.The Wugongshan area,situated in the southeast coast geothermal belt of China,is a typical geothermal anomaly and contains abundant medium-and low-temperature geothermal resources.This study employed hydrogeochemical and isotopic techniques to explore the cyclic evolution of geothermal water in the western Wugongshan region,encompassing the recharge origin,water-rock interaction mechanisms,and residence time.The results show that the geothermal water in the western region of Wugongshan is weakly alkaline,with low enthalpy and mineralization levels.The hydrochemistry of geothermal waters is dominated by Na-HCO_(3)and Na-SO_(4),while the hydrochemistry types of cold springs are all Na-HCO_(3).The hydrochemistry types of surface waters and rain waters are NaHCO_(3)or Ca-HCO_(3).The δD and δ^(18)O values reveal that the geothermal waters are recharged by atmospheric precipitation at an altitude between 550.0 and 1218.6 m.Molar ratios of maj or solutes and isotopic compositions of^(87)Sr/^(86)Sr underscore the significant role of silicate weathering,dissolution,and cation exchange in controlling geothermal water chemistry.Additionally,geothermal waters experienced varying degrees of mixing with cold water during their ascent.Theδ^(13)C values suggest that the primary sources of carbon in the geothermal waters were biogenic and organic.Theδ^(34)S value suggests that the sulfates in geothermal water originate from sulfide minerals in the surrounding rock.Age dating using 3H and^(14)C isotopes suggests that geothermal waters have a residence time exceeding 1 kaBP and undergo a long-distance cycling process.

Identifying the Hydrochemical Characteristics,Genetic Mechanisms and Potential Human Health Risks of Fluoride and Nitrate Enriched Groundwater in the Tongzhou District,Beijing,North China

Fluoride and nitrate enriched groundwater are potential threats to the safety of the groundwater supply that may cause significant effects on human health and public safety,especially in aggregated population areas and economic hubs.This study focuses on the high F^(−)and NO_(3)^(−)concentration groundwater in Tongzhou District,Beijing,North China.A total of 36 groundwater samples were collected to analyze the hydrochemical characteristics,elucidate genetic mechanisms and evaluate the potential human health risks.The results of the analysis indicate:Firstly,most of the groundwater samples are characterized by Mg-HCO_(3) and Na-HCO_(3) with the pH ranging from 7.19 to 8.28 and TDS with a large variation across the range 471-2337 mg/L.The NO_(3)^(−)concentration in 38.89%groundwater samples and the F^(−)concentration in 66.67%groundwater samples exceed the permissible limited value.Secondly,F^(−)in groundwater originates predominantly from water-rock interactions and the fluorite dissolution,which is also regulated by cation exchange,competitive adsorption of HCO_(3)−and an alkaline environment.Thirdly,the effect of sewage disposal and agricultural activities have a significant effect on high NO3-concentration,while the high F^(−)concentration is less influenced by anthropogenic activity.The alkaline environment favors nitrification,thus being conducive to the production of NO_(3)^(−).Finally,the health risk assessment is evaluated for different population groups.The results indicate that high NO_(3)^(−)and F^(−)concentration in groundwater would have the largest threat to children’s health.The findings of this study could contribute to the provision of a scientific basis for groundwater supply policy formulation relating to public health in Tongzhou District.

Numerical Simulation of Rainfall-induced Xianchi Reservoir Landslide in Yunyang,Chongqing,China

A calamitous landslide happened at 22:00 on September 1,2014 in the Yunyang area of Chongqing City,southwest China,enforcing the evacuation of 508 people and damaging 23 buildings.The landslide volume comprised 1.44 million m^(3) of material in the source area and 0.4 million m^(3) of shoveled material.The debris flow runout extended 400 m vertically and 1600 m horizontally.The Xianchi reservoir landslide event has been investigated as follows:(1)samples collected from the main body of landslide were carried out using GCTS ring shear apparatus;(2)the parameters of shear and pore water pressure have been measured;and(3)the post-failure characteristics of landslide have been analyzed using the numerical simulation method.The excess pore-water pressure and erosion in the motion path are considered to be the key reasons for the long-runout motion and the scale-up of landslides,such as that at Xianchi,were caused by the heavy rainfall.The aim of this paper is to acquired numerical parameters and the basic resistance model,which is beneficial to improve simulation accuracy for hazard assessment for similar to potentially dangerous hillslopes in China and elsewhere.

自体动静脉内瘘狭窄与转化生长因子-β1/Smad4信号通路的关系

目的探讨自体动静脉内瘘(AVF)狭窄与转化生长因子(TGF)-β1/Smad4信号通路的关系。方法选取2017年10月至2020年2月于贵州医科大学附属医院行AVF的60例患者为观察组,选取同期50例因外周血管疾病行血管切除的患者为对照组。比较两组患者的年龄、血钙、血磷、血红蛋白、血全段甲状旁腺激素(iPTH)、β2微球蛋白、C反应蛋白(CRP)水平、Smad4及TGF-β1蛋白水平。结果两组患者年龄、血钙、血磷、血红蛋白、血iPTH、β2微球蛋白、CRP水平比较,差异均无统计学意义(P>0.05)。观察组Smad4蛋白表达量低于对照组,TGF-β1蛋白表达量高于对照组,差异均有统计学意义(P<0.05)。结论TGF-β1、Smad4在透析患者AVF狭窄组织中异常表达,并在静脉内膜增生引起瘘管狭窄的过程中发挥重要作用。

The Psychosomatic Traits of“People with the Five Elements in Traditional Chinese Medicine”:A Qualitative Study

Objective To identify the representative attributes of the five elements of a person with a qualitative methodology and provide the basis for the clinical diagnosis and treatment of“people with the five elements in traditional Chinese medicine(TCM).”Methods Data collected from the literature review,two sessions of brainstorming of experts with related experience in“people with the five elements in TCM”from October 2020 to December 2020,and six rounds of in-depth interviews with 30 participants who had various attributes of the five elements from March 2021 to October 2021 were analyzed.Triangulation was used in this study,and theming and synthesizing were used to analyze the data.Results A total of 31 experts and 30 interviewees participated in this study.The median age of the experts and interviewees were 48.0 and 38.5 years,respectively;51.66%and 54.8%of experts and interviewees,respectively,were men.The descriptors of facial diagrams of“people with the five elements in TCM”were complexion,shape,distribution state of facial bones,convergence trend of facial muscles,and facial expression.A theoretical model of“people with the five elements in TCM”was shaped based on these findings.Conclusion The study suggests a possibility for bridging the gap between personality and bodily state,identifying an avenue for personality research from the perspective of TCM.

基于综合评分法和风险商值法筛选黄河流域特征污染物及风险污染物

随着工业化进程的加快和城市化的发展,大量污染物排入黄河流域,并被频繁检出,威胁生态系统和人类健康。为获取潜在生态环境风险污染物,该研究通过调研2000年1月1日−2022年12月31日Web of Science(WoS)和中国知网(CNKI)数据库中黄河流域已报道的288篇污染物相关文献,使用多指标综合评分法筛选黄河流域的特征污染物,采用风险商值法获取水样和沉积物中的风险污染物。结果表明:①黄河流域共检出10类144种污染物,采用9类共13个筛选指标构建多指标综合评分法,对污染物各项指标进行评分,然后进行K-means聚类分析,按得分高低分为Ⅰ~Ⅵ级,选取得分较高的33种Ⅰ级和Ⅱ级高分值污染物作为黄河流域特征污染物,包括12种有机氯农药、10种多环芳烃、10种多氯联苯和1种邻苯二甲酸酯。②水样污染物浓度和沉积物含量前5种都是重金属、有机氯农药、邻苯二甲酸酯、多环芳烃以及药品和个人护理产品,而且二者顺序完全一致,且多数污染物的浓度之间存在显著相关性。③根据风险最大化原则,使用风险商值法(RQ)分别对水样和沉积物进行风险评估,将RQ≥0.1的污染物列为风险污染物,水样中共筛选出21种风险污染物,其中RQ≥1的高风险污染物有5种,包括硒、铅、苯并[a,h]蒽、苯并[a]蒽和邻苯二甲酸二丁酯。④沉积物中共筛选出19种风险污染物,其中有13种高风险污染物,包括8种多环芳烃(芘、蒽、荧蒽、苊、萘、芴、苯并[a]蒽、苯并[a,h]蒽)、4种重金属(汞、铅、硒、砷)和1种邻苯二甲酸酯(邻苯二甲酸二丁酯)。该研究对相关部门拟定黄河流域污染物监测方案和管控措施有重要参考意义。

紫外分光光度法测定歧化松香中去氢枞酸含量的干扰因素研究

利用液相色谱仪、制备液相色谱仪、气相色谱质谱联用仪,对歧化松香(DR)中去氢枞酸(DA)紫外光谱测定方法的干扰因素进行了详细研究。测定的市售不同省份的5个样品中有2个主要干扰物质,进一步定性,确定干扰物质1为6,8,11,13-枞四烯酸(ATA),干扰物质2为混合物,主要检出物为去氢枞醛(D)和枞酸(AA)。采用二阶导数光谱法和偏最小二乘(PLS)法对紫外光谱数据进行分析,以消除去氢枞酸紫外分光光度法的干扰,结果表明:PLS法比二阶导数光谱法误差更小,能够同时消除多种干扰因素,使测试结果更加接近真实值。

以问题为导向联合线上学习模式在缺血性脑血管病专业进修中的应用分析

目的探讨以问题为导向联合线上学习模式相比于非问题为导向的线下学习模式在缺血性脑血管病专业进修中的可行性及有效性。方法采取问卷调查法对2017年1月至2023年1月在首都医科大学宣武医院介入放射中心接受过系统培训的152名进修医师进行回访。根据进修时间以及学习模式的不同,将2017年1月至2020年1月进修方式为非问题为导向的线下学习模式的进修医师纳入非问题为导向组,将2020年2月至2023年1月进修方式为以问题为导向联合线上学习模式的进修医师纳入以问题为导向组。于培训结束时以及结束2个月后进行问卷调查。问卷内容包括:进修医师的性别、年龄,参与培训前已有的工作年限,参加进修培训的目的,培训时长,对培训的感受、建议和意见,培训结束后是否开展新手术(主要包括颅内外动脉支架置入术、颈动脉内膜切除术、杂交手术、动脉旁路移植术、急诊取栓术或其他)和培训结束后开展的新手术数量。结果(1)共发放问卷调查表152份,参与问卷调查并完成反馈者136名,其中4份问卷填写不全或填写错误,排除无效问卷后,剩余有效问卷调查表共132份,回收率和有效应答率分别为89.5%和97.1%。参与培训时,进修医师的年龄为25~44岁,平均(34±4)岁。医师的工作年限分布不等,>10年者占22.7%(30/132),>5~10年者占40.9%(54/132),0~5年者占36.4%(48/132)。不同工作年限者间是否开展新手术的比例差异有统计学意义(χ^(2)=2.501,P=0.012)。(2)参与以问题为导向和非问题为导向两种培训模式的人数分别为70人和62人。以问题为导向组中,希望通过培训学习新技术和提高手术能力的进修医师占88.6%(62/70),而在非问题为导向组中,该比例为87.1%(54/62),两组进修医师的进修培训目的差异无统计学意义(χ^(2)=0.067,P=0.796)。对培训体会进行分析显示,认为现有的培训形式合理和内容较为充实的进修医师占比为96.2%(127/132),以问题为导向组和非问题为导向组中比例分别为97.1%(68/70)和95.2%(59/62),两组差异无统计学意义(χ^(2)=0.354,P=0.552)。(3)经过培训后,以问题为导向组开展新手术的进修医师比例为80.0%(56/70),非问题为导向组的比例为66.1%(41/62),两组差异无统计学意义(χ^(2)=3.247,P=0.072)。在开展新手术的数量方面,以问题为导向组和非问题为导向组中,开展新手术数量≥30例的进修医师比例分别为70.0%(49/70)和46.8%(29/62),两组差异有统计学意义(χ^(2)=7.337,P=0.007)。(4)在非问题为导向组中,开展新手术例数≥30例的进修医师进修时长为3、6、12个月者分别占13.8%(4/29)、82.8%(24/29)、3.4%(1/29);在以问题为导向组中,开展新手术例数≥30例的进修医师进修时长为3、6、12个月者分别占4.1%(2/49)、57.1%(28/49)、38.8%(19/49),两组差异有统计学意义(χ^(2)=3.531,P<0.01)。结论以问题为导向联合线上学习模式有助于中青年神经外科医师的新手术开展以及增加开展的新手术数量,但需结合既往的工作年限和进修时长作为参考。

8种杀螨剂对新疆棉田棉叶螨的防效评价

为探索不同杀螨剂对新疆棉田棉叶螨防治效果,在博尔塔拉蒙古自治州开展试验研究了8种杀螨剂对北疆棉田棉叶螨的防治效果。结果显示:25%(质量分数,下同)三唑锡悬浮剂(SC)和56%阿维·炔螨特微乳剂(ME)具有很好的速效性和持效性,而30%腈吡螨酯SC、20%丁氟螨酯SC、30%乙唑螨腈SC和5%阿维菌素SC处理对棉叶螨的防效随时间延长而提高,具有较好持效性;22%螺虫乙酯SC+助剂(哈速腾)速效性相对较好,持效性表现优良,而110 g·L^(-1)乙螨唑SC速效性和持效性均较差。结果初步表明,以上8种杀螨剂,除乙螨唑以外,其余药剂在试验剂量下对棉叶螨均表现出较好的防治效果,可轮换在棉田使用。

生态系统理论指导下的营养管理对急性淋巴细胞白血病化疗患儿营养状态的影响

目的:分析生态系统理论指导下的营养管理对急性淋巴细胞白血病(ALL)化疗患儿营养状态的影响。方法:选取2021年1月至2021年12月郑州大学第一附属医院收治的86例ALL患儿,采用群随机的方法分为对照组和观察组,每组各43例。对照组采取常规的营养管理,观察组采用生态系统理论指导下的营养管理。干预前后采用全自动生化仪检测血清白蛋白(ALB)、前白蛋白(PA)和转铁蛋白(TFN)水平,测量患儿上臂围、三角肌皮褶厚度,采用Piper疲乏量表评估癌因性疲乏程度。记录患儿干预期间不良反应发生情况。结果:干预后观察组血清ALB、PA、TFN、上臂围较干预前的下降幅度小于对照组(P<0.05),躯体疲乏、认知疲乏、情感疲乏、综合疲乏评分下降幅度大于对照组(P<0.05)。观察组粒细胞减少、血小板减少、肝损伤、恶心呕吐、腹泻和黏膜炎症的总不良反应发生率均低于对照组(P<0.05)。结论:生态系统理论指导的营养管理可有效维持ALL化疗患儿的营养状态,提高患儿化疗耐受性。

不同年龄段婴儿1177例维生素K1与K2水平分布调查分析

目的探讨对比各年龄段婴儿血清维生素K1与K2水平,了解维生素K1与K2在不同年龄段婴儿体内的分布情况。方法选取课题单位(儿科、新生儿科、儿童保健科、产科)出生/就诊的儿童作为研究对象,按年龄为0~3 d(591例)、4~7 d(255例)、8~15 d(104例)、1个月(118例)、2个月(40例)、3个月(69例)进行分组。收集患者的一般资料,采用统一平台的高效液相色谱-质谱(LC-MS)法测定患者血清维生素K1与K2水平,从维生素K1与K2不同年龄段的水平分布,缺乏率进行数据分析。结果各年龄段的维生素K1与K2水平分布具有统计学意义(P<0.001);新生儿极易缺乏维生素K1,随着年龄增长,维生素K2的缺乏率高于维生素K1。结论维持维生素K1及K2的正常对于各年龄段婴幼儿的正常生长发育至关重要,应当密切关注婴幼儿维生素K1及K2的监测和补充。

2023年LIS期刊论文研究方法应用态势

研究方法的选择和运用影响研究的深度和可靠性,对科学研究发展十分重要。文章在总结LIS领域方法论研究的基础上,将LIS领域常用的研究方法整理、汇总、编码,以LIS领域11种TOP期刊2023年收录的论文为数据源,统计分析LIS期刊论文的研究方法应用态势,探讨LIS学科性质、研究对象、作者学科背景等因素对研究方法的影响。研究发现:LIS领域论文使用的研究方法内容不断演进,跨学科和新兴理论方法以及多元研究方法的应用促进了研究的深入和丰富。

结直肠息肉冷圈套切除术的临床疗效分析

目的对内镜下冷圈套器息肉切除术(CSP)的临床疗效进行对照研究,评估CSP在结直肠息肉切除中的实用性、有效性及安全性,探讨其应用价值。方法收集2019年1月至2021年12月银川市第一人民医院肠镜检查中检出的直径3~10 mm息肉共694枚,按照息肉直径分成微小息肉组及小息肉组,对于微小息肉组,对照分析CSP及冷活检钳夹术(CFP)两种处理术式的完全切除率;对于小息肉组,对照分析CSP及内镜下黏膜切除术(EMR)两种处理术式的迟发性出血率、穿孔率及钛夹利用率。结果微小息肉组中CFP与CSP两种处理术式,息肉直径差异无统计学意义(P>0.05),CFP组息肉完全切除率为72.6%,低于CSP组的98.6%(P<0.05)。小息肉组中CSP与EMR处理术式在息肉直径、息肉完全切除率间差异无统计学意义(P均>0.05);CSP处理术式的迟发性出血率、穿孔率及钛夹利用率均低于EMR(P均<0.05)。结论在切除微小息肉时,CSP的完全切除率比CFP更高;在切除小息肉时,CSP比EMR更加安全、经济。CSP在切除结直肠微小息肉及小息肉时,具备更多的优势,可在临床上推广应用。

研究生数据素养对科研创新能力的影响研究

数据素养是研究生开展学术研究的关键,是培养研究生科研创新能力的基础。本研究以硕士研究生为对象,运用结构方程模型(SEM)展开实证研究,构建研究生数据素养对科研创新能力的影响模型。结果表明:(1)研究生数据素养5个变量对科研创新能力产生正向显著的影响;(2)数据分析应用能力和数据获取能力对研究生科研素养具有较强的正向影响效应,影响系数分别为0.63和0.57;(3)数据处理能力(0.36)和数据意识(0.25)对研究生的科研创新能力具有较弱的正向影响效应。根据研究结果,提出如下建议:构建意识驱动、数据实践、伦理守门三位一体的培养引导机制;塑造学校数据文化,构建完善的数据素养课程体系;完善数据资源设施,优化研究生科研创新平台等重要建议,促进研究生数据素养和科研创新能力提升。

神经电生理监测下MVD术对面肌痉挛患者临床疗效及并发症的影响

目的:探究神经电生理监测下微血管减压(MVD)术对面肌痉挛(HFS)患者的临床治疗效果以及并发症的影响。方法:选取2016年5月—2021年6月郑州大学第五附属医院收治的78例HFS患者作为研究对象,按随机数表法分为对照组(39例)与监测组(39例)。两组患者均给予MVD术进行治疗,监测组患者在实施MVD术中进行神经电生理监测。观察监测组患者面神经侧方扩散反应(LSR)情况以及脑干听觉诱发电位(BAEP)中的V波情况,比较两组患者术后临床治疗效果以及术后并发症发生情况。结果:通过对监测组患者在MVD术中进行神经电生理监测发现,其中有5例患者LSR波形消失是在进行桥小脑角探测检查时,32例患者是在进行神经减压时消失,其余2例患者直至MVD手术结束LSR波形仍然可见。术后1 d,监测组患者治疗总有效率较对照组更高,差异有统计学意义(P<0.05);监测组患者并发症总发生率较对照组更低,差异有统计学意义(χ^(2)=22.675,P<0.05)。结论:HFS患者在神经电生理监测下实施MVD术进行治疗,临床治疗效果较为显著,同时,患者的并发症发生情况较少,比临床治疗HFS患者时单独采用MVD术进行治疗的方式更具优势,值得临床借鉴参考。

Experimental Study on Pharmacodynamic of Qingyan Granules

Objective: To investigate the pharmacodynamics of Qingyan granules. Methods: To investigate the efficancy of qingyan granules, the animal experience of maximum tolerated dose of mice was made. And the auricular swelling model of mice, the foot swelling model of rat, the phenol red secretion method, and the hot-plate and glacial acetic acid stimulation writhing method was established and used to test the anti-inflammatory effect, the expectorant effect, and the analgesia effect. Results: Pharmacodynamics experiment proved that the maximum dosage for mice was 42g/kg, the equivalent of 56 times for human. Qingyan granules has obvious inhibitory effect on mouse auricle swelling caused by xylene, and has obvious inhibitory effect on carrageenan-induced rat paw edem. Also, the mice pain caused by thermal and chemical stimulation has obviously inhibited by Qingyan granules. Qingyan granules can prolong the pain reaction time on mice caused by acetic acid. Conclusions: Qingyan granules have evident effects of anti-inflammatory effect, analgesic effect and expectorant effect.

ICT应用下居家养老服务“数字鸿沟”的形成机理与规划对策研究——以福州市中心城区为例

当前我国社会正处于老龄化与信息化相互交织的关键时期。研究ICT应用下城市老年人获取居家养老服务过程中“数字鸿沟”问题的形成机理与规划对策,对于老年友好社区的智慧化升级与智慧社区的适老化设计有重要意义。以福州市中心城区为例,运用回归分析等方法,分析不同类型老年人的信息化水平,比较其对不同类型ICT智慧居家养老服务的使用意愿与使用能力,进而探究ICT智慧居家养老服务“数字鸿沟”的影响因素、形成原因和发生场景。在此基础上,结合福州市居家养老服务设施建设现状,提出社区信息中心的功能组织与空间配置策略,以期为弥合城市老年人智慧居家养老“数字鸿沟”、提升智慧养老服务供需匹配水平提供借鉴。

应当尊重教科书的正当权威——基于研究者泛教科书批判的现象学研究

近年来,有关教科书二次开发的研究很多,但不少研究是对纸质教科书的有罪推定,对后现代主义课程观的牵强附会,对智能化数字教科书的盲目自信,对已有研究结论的低水平重复,严重消解了教科书本身的权威属性。对教科书的现有批判进行再批判可以发现:后现代主义教科书开发路径缺乏行动方案和操作程序;数字教科书内容创编易加大认知负荷和数字鸿沟;研究结论低水平重复会导致学术假问题和伪创新。事实上,教科书的正当权威是教科书的本质属性和实是信念,它提供了合法知识和经典价值,象征着国家意志和民主策略,彰显着课程逻辑和教学确证。因此,教科书研究者应当严谨治学,坚守学术智识,切忌盲从跟风。

Treatment Outcomes in COVID-19 Patients with Brucellosis:Case Series in Heilongjiang and Systematic Review of Literature

Objective Clinical characteristics and outcome in COVID-19 with brucellosis patients has not been well demonstrated,we tried to analyze clinical outcome in local and literature COVID-19 cases with brucellosis before and after recovery.Methods We retrospectively collected hospitalization data of comorbid patients and prospectively followed up after discharge in Heilongjiang Infectious Disease Hospital from January 15,2020 to April29,2022.Demographics,epidemiological,clinical symptoms,radiological and laboratory data,treatment medicines and outcomes,and follow up were analyzed,and findings of a systematic review were demonstrated.Results A total of four COVID-19 with brucellosis patients were included.One patient had active brucellosis before covid and 3 patients had nonactive brucellosis before brucellosis.The median age was54.5 years,and all were males(100.0%).Two cases(50.0%)were moderate,and one was mild and asymptomatic,respectively.Three cases(75.0%)had at least one comorbidity(brucellosis excluded).All4 patients were found in COVID-19 nucleic acid screening.Case C and D had only headache and fever on admission,respectively.Four cases were treated with Traditional Chinese medicine,western medicines for three cases,no adverse reaction occurred during hospitalization.All patients were cured and discharged.Moreover,one case(25.0%)had still active brucellosis without re-positive COVID-19,and other three cases(75.0%)have no symptoms of discomfort except one case fell fatigue and anxious during the follow-up period after recovery.Conducting the literature review,two similar cases have been reported in two case reports,and were both recovered,whereas,no data of follow up after recovery.Conclusion These cases indicate that COVID-19 patients with brucellosis had favorable outcome before and after recovery.More clinical studies should be conducted to confirm our findings.