Using bioinformatics methods,79 functional SNPs of 44 finger bone development genes potentially related to the formation of digit ratio were selected.In our study,the relationship between 2D:4D and the above SNPs geno...Using bioinformatics methods,79 functional SNPs of 44 finger bone development genes potentially related to the formation of digit ratio were selected.In our study,the relationship between 2D:4D and the above SNPs genotyped by using multiple PCR method was evaluated in a Ningxia population(400 men and 408 women).L2D:4D was statistically different among different genotypes of rs3809346(COL4A2)in whole population and female;R2D:4D was different among genotypes in the female and the genotype carrying minor allele A had increased R2D:4D in the additive genetic model.L2D:4D was statistically different among rs3825490(COL4A2)in the whole population and male,and L2D:4D of T/T genotype under recessive model was higher than the C/C-T/C genotype.A statistical difference was found in different genotypes of rs7984100(COL4A2)in the whole population.L2D:4D differed among different genotypes for rs1042917(COL6A2).L2D:4D in women was significantly different among rs2839110(COL6A2).L2D:4D in females was different between genotypes of rs755793(FGFR2)gene.R2D:4D was statistically different in genotypes of rs17576(MMP9).展开更多
To analyze the body fat distribution characteristics of Hui and Han college students in Ningxia.Using a bioelectrical impedance analyzer connected with computer to determine the body fat distribution of 808 college st...To analyze the body fat distribution characteristics of Hui and Han college students in Ningxia.Using a bioelectrical impedance analyzer connected with computer to determine the body fat distribution of 808 college students(Hui:417,including 197 males and 220 females;Han:391,including 203 males and 188 females)in Ningxia.展开更多
Depression is a common mental disorder of great sex dimorphism(higher incidence in women).The intrauterine milieu exposure to sex hormones may be results in the increased vulnerability of depression.The second to four...Depression is a common mental disorder of great sex dimorphism(higher incidence in women).The intrauterine milieu exposure to sex hormones may be results in the increased vulnerability of depression.The second to fourth digit ratio(2D:4D)is considered to reflect the prenatal exposure to sex hormones.Thus,our study is to explore the potential relationship between the 2D:4D and the depression in Chinese women.Both hands of 244 females(controls:127,patients:117)and 178 males(controls 124,patients 54)were photographed.2D:4D and left minus right hand(DuR),body mass index(BMI)were compared and analyzed.展开更多
DAVID,METASCAPE,STRING and other gene databases was used to screen the finger bone development genes that may be related to the digit ratio;the online genomic SNP database SNPinfo Web Server was applied to select func...DAVID,METASCAPE,STRING and other gene databases was used to screen the finger bone development genes that may be related to the digit ratio;the online genomic SNP database SNPinfo Web Server was applied to select functional SNPs;79 SNPs of 43 steroid sex hormone genes were genotyped by using multiple PCR method in a healthy Ningxia population(400 men and 408 women).展开更多
Using bioinformatics methods,44 functional SNPs of 21 steroid sex hormone genes potentially related to the formation of digit ratio were selected.In our study,the relationship between 2D:4D and the above SNPs genotype...Using bioinformatics methods,44 functional SNPs of 21 steroid sex hormone genes potentially related to the formation of digit ratio were selected.In our study,the relationship between 2D:4D and the above SNPs genotyped by using multiple PCR method was evaluated in a Ningxia population(400 men and 408 women).展开更多
At present,11 loci have been identified in 2D:4D related GWAS,including rs4927012(GLIS1),rs11581730(EFNA1),rs340600(LDAH),rs12474669(OLA1),rs10790969(FLII),rs847158(HOXD11/12),rs77640775(GLI3),rs2332175(SMOC1),rs64997...At present,11 loci have been identified in 2D:4D related GWAS,including rs4927012(GLIS1),rs11581730(EFNA1),rs340600(LDAH),rs12474669(OLA1),rs10790969(FLII),rs847158(HOXD11/12),rs77640775(GLI3),rs2332175(SMOC1),rs6499762(SALL1),rs1080014(TOX3)and rs4799176(SALL3).In our study,the relationship between 2D:4D and the above SNPs genotyped by using multiple PCR method was evaluated in a Ningxia population(400 men and 408 women).L2D:4D of rs340600(LDAH)was significantly different among genotypes in whole population and female;rs10790969(FLI1)was statistically different among genotypes for L2D:4D in the male.展开更多
Using a bioelectrical impedance method,the body fat distribution characteristics of 808 people(400 males and 408 females)were measured,such as height,weight,body mass index,body fat mass,fat free mass,visceral fat are...Using a bioelectrical impedance method,the body fat distribution characteristics of 808 people(400 males and 408 females)were measured,such as height,weight,body mass index,body fat mass,fat free mass,visceral fat area,soft lean mass,skeletal muscle mass,waist and hip circumference,waist-hip ratio and waist-height ratio.展开更多
Using bioinformatics methods,44 functional SNPs of 21 steroid sex hormone genes potentially related to the formation of digit ratio were selected.The genes were genotyped by using multiple PCR method in a healthy Ning...Using bioinformatics methods,44 functional SNPs of 21 steroid sex hormone genes potentially related to the formation of digit ratio were selected.The genes were genotyped by using multiple PCR method in a healthy Ningxia population(400 men and 408 women).The recessive model of CYP17A1(rs1004467)gene showed sexual differences.AKR1C3(rs12529)gene showed a significantly lower proportion of C/G genotypes in males than in females under the co-dominant model.GPER1(rs12702047)gene,the recessive model was the genetic model with significant sexual differences.展开更多
文摘Using bioinformatics methods,79 functional SNPs of 44 finger bone development genes potentially related to the formation of digit ratio were selected.In our study,the relationship between 2D:4D and the above SNPs genotyped by using multiple PCR method was evaluated in a Ningxia population(400 men and 408 women).L2D:4D was statistically different among different genotypes of rs3809346(COL4A2)in whole population and female;R2D:4D was different among genotypes in the female and the genotype carrying minor allele A had increased R2D:4D in the additive genetic model.L2D:4D was statistically different among rs3825490(COL4A2)in the whole population and male,and L2D:4D of T/T genotype under recessive model was higher than the C/C-T/C genotype.A statistical difference was found in different genotypes of rs7984100(COL4A2)in the whole population.L2D:4D differed among different genotypes for rs1042917(COL6A2).L2D:4D in women was significantly different among rs2839110(COL6A2).L2D:4D in females was different between genotypes of rs755793(FGFR2)gene.R2D:4D was statistically different in genotypes of rs17576(MMP9).
文摘To analyze the body fat distribution characteristics of Hui and Han college students in Ningxia.Using a bioelectrical impedance analyzer connected with computer to determine the body fat distribution of 808 college students(Hui:417,including 197 males and 220 females;Han:391,including 203 males and 188 females)in Ningxia.
文摘Depression is a common mental disorder of great sex dimorphism(higher incidence in women).The intrauterine milieu exposure to sex hormones may be results in the increased vulnerability of depression.The second to fourth digit ratio(2D:4D)is considered to reflect the prenatal exposure to sex hormones.Thus,our study is to explore the potential relationship between the 2D:4D and the depression in Chinese women.Both hands of 244 females(controls:127,patients:117)and 178 males(controls 124,patients 54)were photographed.2D:4D and left minus right hand(DuR),body mass index(BMI)were compared and analyzed.
文摘DAVID,METASCAPE,STRING and other gene databases was used to screen the finger bone development genes that may be related to the digit ratio;the online genomic SNP database SNPinfo Web Server was applied to select functional SNPs;79 SNPs of 43 steroid sex hormone genes were genotyped by using multiple PCR method in a healthy Ningxia population(400 men and 408 women).
文摘Using bioinformatics methods,44 functional SNPs of 21 steroid sex hormone genes potentially related to the formation of digit ratio were selected.In our study,the relationship between 2D:4D and the above SNPs genotyped by using multiple PCR method was evaluated in a Ningxia population(400 men and 408 women).
文摘At present,11 loci have been identified in 2D:4D related GWAS,including rs4927012(GLIS1),rs11581730(EFNA1),rs340600(LDAH),rs12474669(OLA1),rs10790969(FLII),rs847158(HOXD11/12),rs77640775(GLI3),rs2332175(SMOC1),rs6499762(SALL1),rs1080014(TOX3)and rs4799176(SALL3).In our study,the relationship between 2D:4D and the above SNPs genotyped by using multiple PCR method was evaluated in a Ningxia population(400 men and 408 women).L2D:4D of rs340600(LDAH)was significantly different among genotypes in whole population and female;rs10790969(FLI1)was statistically different among genotypes for L2D:4D in the male.
文摘Using a bioelectrical impedance method,the body fat distribution characteristics of 808 people(400 males and 408 females)were measured,such as height,weight,body mass index,body fat mass,fat free mass,visceral fat area,soft lean mass,skeletal muscle mass,waist and hip circumference,waist-hip ratio and waist-height ratio.
文摘Using bioinformatics methods,44 functional SNPs of 21 steroid sex hormone genes potentially related to the formation of digit ratio were selected.The genes were genotyped by using multiple PCR method in a healthy Ningxia population(400 men and 408 women).The recessive model of CYP17A1(rs1004467)gene showed sexual differences.AKR1C3(rs12529)gene showed a significantly lower proportion of C/G genotypes in males than in females under the co-dominant model.GPER1(rs12702047)gene,the recessive model was the genetic model with significant sexual differences.
