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来曲唑有效提高性发育异常男性患儿的睾酮水平 被引量:5
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作者 于冰青 聂敏 +6 位作者 伍学焱 茅江峰 王曦 马婉璐 季文 黄奇彬 张睿 《浙江大学学报(医学版)》 CAS CSCD 北大核心 2020年第3期297-301,共5页
目的:评价第三代非甾体类芳香化酶抑制剂来曲唑治疗男性性发育异常(DSD)患儿的疗效和安全性。方法:收集2014年1月至2016年1月就诊于北京协和医院内分泌科门诊的男性DSD患儿12例,来曲唑治疗(1.25~2.5 mg,1次/d)不少于3个月,随访半年至2.... 目的:评价第三代非甾体类芳香化酶抑制剂来曲唑治疗男性性发育异常(DSD)患儿的疗效和安全性。方法:收集2014年1月至2016年1月就诊于北京协和医院内分泌科门诊的男性DSD患儿12例,来曲唑治疗(1.25~2.5 mg,1次/d)不少于3个月,随访半年至2.5年。采集其临床资料及实验室检查结果,比较治疗前后激素水平及生化指标的差异,并观察治疗中的不良反应。结果:本组患儿来曲唑治疗的平均年龄为(14.6±2.5)岁。来曲唑治疗半年后患者血促性腺激素黄体生成素(LH)、卵泡刺激素(FSH)及睾酮水平较基线升高(均P<0.05),雌二醇水平较基线下降(P<0.05);治疗1年后患者睾酮水平较基线高(P<0.05),LH及FSH水平较基线高,雌二醇水平较基线下降,但差异无统计学意义(均P>0.05)。8例患儿进行精液常规检测,其中3例尿道下裂患儿精液中可检测到精子。所有患儿治疗前后生化检查无明显变化,用药后无明显不良反应。结论:来曲唑可有效提高DSD患儿的睾酮水平,促进精子生成,且短期应用未见明显不良反应。 展开更多
关键词 性发育障碍/药物疗法 芳香酶抑制剂/治疗应用 来曲唑 睾酮 儿童
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Radiative Recombination Rates Enhancement at Low Energy Range in the Heavy Ion Storage Ring CSRm
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作者 Khan Nadir Huang Zhongkui +15 位作者 Wen Weiqiang Wang Shuxing Wang Hanbing ma wanlu Zhu Xiaolong Zhao Dongmei Zhu Linfan mao Lijun Li Jie ma Xiaoming Tang Meitang Yin Dayu Yang Weiqing Yang Jiancheng Yuan Youjin ma Xinwen 《IMP & HIRFL Annual Report》 2019年第1期74-75,共2页
Recombination of Ar^(14+),Ar^(15+),Ca^(16+) and Ni^(19+) ions with electrons has been investigated at low energy range at the CSRm.For each ion,the absolute recombination rate coefficients have been measured with elec... Recombination of Ar^(14+),Ar^(15+),Ca^(16+) and Ni^(19+) ions with electrons has been investigated at low energy range at the CSRm.For each ion,the absolute recombination rate coefficients have been measured with electron-ion collision energies from 0 to 1000 meV which include the radiative recombination(RR)and also dielectronic recombination(DR)processes.In order to interpret the measured results. 展开更多
关键词 processes. ABSOLUTE COLLISION
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Dielectronic Recombination of Na-like Kr^(25+) at the CSRm
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作者 Huang Zhongkui Wen Weiqiang +15 位作者 Wang Shuxing ma wanlu Wang Hanbing Nadir Khan Zhao Dongmei Zhu Xiaolong mao Lijun Li Jie ma Xiaoming Yin Dayu mao Ruishi Yuan Youjin Yang Jiancheng Chen Chongyang Zhu Linfan ma Xinwen 《IMP & HIRFL Annual Report》 2019年第1期72-72,共1页
The absolute rate coefficients for dielectronic recombination(DR)of Na-like Kr^(25+) ions were measured by employing the electron-ion merged-beam technique at the heavy-ion storage ring CSRm.The measured DR spectrum c... The absolute rate coefficients for dielectronic recombination(DR)of Na-like Kr^(25+) ions were measured by employing the electron-ion merged-beam technique at the heavy-ion storage ring CSRm.The measured DR spectrum covers the energy range of 0~70 eV. 展开更多
关键词 ABSOLUTE SPECTRUM BEAM
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Changes of sex hormones and sex hormone-binding globulin levels in male adults with hyperthyroidism before and after antithyroid drug treatment
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作者 马婉璐 《China Medical Abstracts(Internal Medicine)》 2019年第3期147-148,共2页
Objective To observe the changes of sex hormone and sex hormone-binding globulin(SHBG)levels in young male patients with hyperthyroidism before and after antithyroid drug(ATD)treatment.Methods Between January 2015 and... Objective To observe the changes of sex hormone and sex hormone-binding globulin(SHBG)levels in young male patients with hyperthyroidism before and after antithyroid drug(ATD)treatment.Methods Between January 2015 and July 2016,forty male patients with hyperthyroidism aged 19-52 years(with an median age of 33.1 years)were enrolled in the Department of Endocrinology of Peking Union Medical College Hospital.Blood samples were taken before treatment and at 1 month,2 months,3 months and 5 months after treatment to evaluate thyroid function,follicle stimulating hormone(FSH),luteinizing hormone(LH),testosterone(T),free testosterone(FT),estradiol(E2),prolactin and SHBG.Results A total of 40 patients were enrolled but only 35 patients completed the follow-up.The patients had high levels of thyroid function,SHBG and sex hormones before treatment.Before treatment,free thyroxine(FT4),free triiodothyronine(FT3),SHBG,LH,estradiol,testosterone and free testosterone was(0.30±0.12)pmol/L,(9.68±4.73)pmol/L,(146±111)nmol/L,(8.41±3.61)U/L,(19.9±7.7)pmol/L,(29.9±9.5)nmol/L and(0.24±0.08)nmol/L,respectively.After treatment,the level of triiodothyronine,thyroxine,FT3,and FT4 gradually decreased to normal(all P<0.001).Thyroid stimulating hormone(TSH)gradually increased to normal(P<0.001).LH and estradiol levels gradually decreased(all P<0.001).FSH decreased but the difference was not statistically significant.Prolactin did not change significantly.Testosterone and SHBG levels decreased significantly while the levels of free testosterone,free testosterone percentage(FT%),bio-available testosterone(BAT),bio-available testosterone percentage(BAT%),free androgen index(FAI)gradually increased and stabilized(all P<0.001).The difference was not statistically significant between T/LH and E2/LH before and after treatment(all P>0.05).However FT/LH gradually increased and its difference was statistically significant(P<0.001).Conclusion The levels of LH,estradiol,testosterone and SHBG in male patients with hyperthyroidism significantly increased,while the free testosterone level decreased,but they all gradually returned to normal with the lowering of thyroid hormone levels during ATD treatment. 展开更多
关键词 BLOOD GLOBULIN treatment
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