The rise of resistance to all known antibiotics is a global crisis.In addition to novel treatment options,there is an urgent need to develop rapid,specific,sensitive,and reliable diagnostic methods to detect pathogeni...The rise of resistance to all known antibiotics is a global crisis.In addition to novel treatment options,there is an urgent need to develop rapid,specific,sensitive,and reliable diagnostic methods to detect pathogenic bacteria in clinical samples and reduce the overuse and misuse antibiotics.Pseudopaline,a metallophore produced by the human pathogen Pseudomonas aeruginosa,transports divalent metal ions via a dedicated active transport system,making it an ideal carrier for a second functional moiety.展开更多
基金from the National Key Research and Development Program of China(no.2017YFA0505200)the National Natural Science Foundation of China Grant(nos.21625201,21961142010,21661140001,91853202,and 21521003)+1 种基金the Beijing Outstanding Young Scientist Program(no.BJJWZYJH01201910001001)a special research grant for early drug discovery from Roche Pharma Research&Early Development is gratefully acknowledged.
文摘The rise of resistance to all known antibiotics is a global crisis.In addition to novel treatment options,there is an urgent need to develop rapid,specific,sensitive,and reliable diagnostic methods to detect pathogenic bacteria in clinical samples and reduce the overuse and misuse antibiotics.Pseudopaline,a metallophore produced by the human pathogen Pseudomonas aeruginosa,transports divalent metal ions via a dedicated active transport system,making it an ideal carrier for a second functional moiety.
