Malaria caused by the Plasmodium falciparum parasite is responsible for more than 240 million cases per year and killed 627,000 people in 2020,mostly African children.The malaria parasite is transmitted by mosquitos b...Malaria caused by the Plasmodium falciparum parasite is responsible for more than 240 million cases per year and killed 627,000 people in 2020,mostly African children.The malaria parasite is transmitted by mosquitos belonging to the genus Anopheles.After an asymptomatic liver stage,the parasite is released into the bloodstream to invade red blood cells(RBCs)and replicate asexually.This erythrocytic phase is associated with a variety of clinical manifestations,including mild and severe malaria.Cerebral malaria(CM)is one of the most severe forms,characterized by the sequestration of parasitized RBCs in the small capillaries of the brain and the local development of cytokine-mediated inflammation.Genetic variants in genes encoding proteins involved in red blood cell physiology are protective factors against severe malaria,as clearly demonstrated for the sickle cell variant of hemoglobin(HbS).展开更多
基金supported by the African Higher Education Centers of Excellence Project(CEA-SAMEF)at UCAD,the Pasteur Institute in Dakar,the Pasteur Institute in Paris,the French Embassy in Senegal,INSERM,and Aix-Marseille University.MA and SN were supported by a Ph.D.fellowship from the French Ministry of Research and the Higher Education Commission(HEC)in Pakistan,respectivelysupport from the French Government under the France 2030 Investment Plan,as part of the Initiative d'Excellence d'Aix-Marseille Université-A∗MIDEX-Institute MarMaRa(No.AMX-19-IET-007).
文摘Malaria caused by the Plasmodium falciparum parasite is responsible for more than 240 million cases per year and killed 627,000 people in 2020,mostly African children.The malaria parasite is transmitted by mosquitos belonging to the genus Anopheles.After an asymptomatic liver stage,the parasite is released into the bloodstream to invade red blood cells(RBCs)and replicate asexually.This erythrocytic phase is associated with a variety of clinical manifestations,including mild and severe malaria.Cerebral malaria(CM)is one of the most severe forms,characterized by the sequestration of parasitized RBCs in the small capillaries of the brain and the local development of cytokine-mediated inflammation.Genetic variants in genes encoding proteins involved in red blood cell physiology are protective factors against severe malaria,as clearly demonstrated for the sickle cell variant of hemoglobin(HbS).
