Jiuzhaigou of Sichuan Province is a world cultural heritage site and wonderful scenic spot where you could spend the hot summer there.Located in the Jiuzhaigou County,Aba Tibetan and Qiang Autonomous Prefecture,Jiuzha...Jiuzhaigou of Sichuan Province is a world cultural heritage site and wonderful scenic spot where you could spend the hot summer there.Located in the Jiuzhaigou County,Aba Tibetan and Qiang Autonomous Prefecture,Jiuzhaigou earned its name for nine Tibetan villages spreading among the lakes in a plateau lake area.展开更多
Known as 'South of the Clouds',Yunnan is known to the world for its beautiful and magic scenery,and bountiful resources.It is known as 'different tribes living in the same mountain,and different views in t...Known as 'South of the Clouds',Yunnan is known to the world for its beautiful and magic scenery,and bountiful resources.It is known as 'different tribes living in the same mountain,and different views in the same mountain'.It attracts tourists from all over the world as it is called a 'magical land'.Kunming is the city of spring with unique sceneries.It is as warm as展开更多
Lipids exert many essential physiological functions,such as serving as a structural component of biological membranes,storing energy,and regulating cell signal transduction.Dysregulation of lipid metabolism can lead t...Lipids exert many essential physiological functions,such as serving as a structural component of biological membranes,storing energy,and regulating cell signal transduction.Dysregulation of lipid metabolism can lead to dyslipidemia related to various human diseases,such as obesity,diabetes,and cardiovascular disease.Therefore,lipid metabolism is strictly regulated through multiple mechanisms at different levels,including the extracellular matrix.Membrane-type I matrix metalloproteinase(MT1-MMP),a zinc-dependent endopeptidase,proteolytically cleaves extracellular matrix components,and non-matrix proteins,thereby regulating many physiological and pathophysiological processes.Emerging evidence supports the vital role of MT1-MMP in lipid metabolism.For example,MT1-MMP mediates ectodomain shedding of low-density lipoprotein receptor and increases plasma low-density lipoprotein cholesterol levels and the development of atherosclerosis.It also increases the vulnerability of atherosclerotic plaque by promoting collagen cleavage.Furthermore,it can cleave the extracellular matrix of adipocytes,affecting adipogenesis and the development of obesity.Therefore,the activity of MT1-MMP is strictly regulated by multiple mechanisms,such as autocatalytic cleavage,endocytosis and exocytosis,and post-translational modifications.Here,we summarize the latest advances in MT1-MMP,mainly focusing on its role in lipid metabolism,the molecular mechanisms regulating the function and expression of MT1-MMP,and their pharmacotherapeutic implications.展开更多
文摘Jiuzhaigou of Sichuan Province is a world cultural heritage site and wonderful scenic spot where you could spend the hot summer there.Located in the Jiuzhaigou County,Aba Tibetan and Qiang Autonomous Prefecture,Jiuzhaigou earned its name for nine Tibetan villages spreading among the lakes in a plateau lake area.
基金supported Chicago Diahetes Project(CDP)National Institutes of Health(NIH)ROl DK091526,R25 DK105924-01Natural ScienceFoundation of Tianjin,China(13JCYBJC42600)
文摘Known as 'South of the Clouds',Yunnan is known to the world for its beautiful and magic scenery,and bountiful resources.It is known as 'different tribes living in the same mountain,and different views in the same mountain'.It attracts tourists from all over the world as it is called a 'magical land'.Kunming is the city of spring with unique sceneries.It is as warm as
基金supported by grants from the Canadian Institutes of Health Research(PS 155994)the Natural Sciences and Engineering Research Council of Canada(RGPIN-2016-06479)the National Natural Science Foundation of China(Joint Research Fund for Overseas Chinese Scholars and Scholars in Hong Kong and Macao,NSFC 81929002).
文摘Lipids exert many essential physiological functions,such as serving as a structural component of biological membranes,storing energy,and regulating cell signal transduction.Dysregulation of lipid metabolism can lead to dyslipidemia related to various human diseases,such as obesity,diabetes,and cardiovascular disease.Therefore,lipid metabolism is strictly regulated through multiple mechanisms at different levels,including the extracellular matrix.Membrane-type I matrix metalloproteinase(MT1-MMP),a zinc-dependent endopeptidase,proteolytically cleaves extracellular matrix components,and non-matrix proteins,thereby regulating many physiological and pathophysiological processes.Emerging evidence supports the vital role of MT1-MMP in lipid metabolism.For example,MT1-MMP mediates ectodomain shedding of low-density lipoprotein receptor and increases plasma low-density lipoprotein cholesterol levels and the development of atherosclerosis.It also increases the vulnerability of atherosclerotic plaque by promoting collagen cleavage.Furthermore,it can cleave the extracellular matrix of adipocytes,affecting adipogenesis and the development of obesity.Therefore,the activity of MT1-MMP is strictly regulated by multiple mechanisms,such as autocatalytic cleavage,endocytosis and exocytosis,and post-translational modifications.Here,we summarize the latest advances in MT1-MMP,mainly focusing on its role in lipid metabolism,the molecular mechanisms regulating the function and expression of MT1-MMP,and their pharmacotherapeutic implications.
