Human-mouse chimeras offer advantages for studying the pathophysiology of human cells in vivo.Chimeric mouse brains have been created by engrafting human fetal tissue-or pluripotent stem cell-derived progenitor cells ...Human-mouse chimeras offer advantages for studying the pathophysiology of human cells in vivo.Chimeric mouse brains have been created by engrafting human fetal tissue-or pluripotent stem cell-derived progenitor cells into the neonatal mouse brain.This provides new opportunities to understand human brain development and neurological disorders.展开更多
基金This work was in part supported by grants from the NIH(R01NS102382,R01NS122108,and R01AG073779 to P.J.).
文摘Human-mouse chimeras offer advantages for studying the pathophysiology of human cells in vivo.Chimeric mouse brains have been created by engrafting human fetal tissue-or pluripotent stem cell-derived progenitor cells into the neonatal mouse brain.This provides new opportunities to understand human brain development and neurological disorders.
