Pseudomonas aeruginosa (P. aeroginosa) is one of the opportunistic pathogens, which is the main cause of prevalent hospital infections worldwide. The aim of this study was to determine the prevalence of antibiotic res...Pseudomonas aeruginosa (P. aeroginosa) is one of the opportunistic pathogens, which is the main cause of prevalent hospital infections worldwide. The aim of this study was to determine the prevalence of antibiotic resistance pattern against P. aeroginosa from clinical samples in our population. This study was performed during March 2009 to September 2011. During this period 233 clinical isolated samples from hospital patients were examined. In these studies, different strains of P. aeroginosa were isolated from samples, then microbiologically tested. Bacterial susceptibility was performed by the disc-diffusion tests with Kirby Baur disc diffusion tests in Muller-Hinto environment. Our results showed maximum antibiotic resistance (99.5%) of P. aeruginosa against Trimetoprime Solfametoxasole and Ciprofloxacin (55.33%), Amikacin (61%), Imipenem (33%), which were identified as the most effective antibiotics in this study. In conclusion, indeed most Pseudomonas aeruginosa strains infections are treated as soon as possible due to their severe resistance against antibiotics. So, we have to apply an accurate antibiotic treatment discipline, according to the finding, based on antibiogram, in order to prevent its spread and also, monitoring and optimization of antimicrobial use should be considered carefully.展开更多
It seems that defects on micro-minerals levels have an etiologic role involved in type 1 diabetes mellitus pathogenicity. The aim of our study were to evaluate the serum levels of zinc and iron and investigate their p...It seems that defects on micro-minerals levels have an etiologic role involved in type 1 diabetes mellitus pathogenicity. The aim of our study were to evaluate the serum levels of zinc and iron and investigate their possible relationship between these biochemical parameters with demographic conditions and glycemic control in patients with type 1 diabetes mellitus disorder. In this case-control based study, 68 female with type 1 diabetes mellitus with a mean age of 52.2 ±2 as case group and 122 healthy women as a control group with a mean age of 49/4 ±3/2 were investigated .for biochemical analysis ,10 mL fasting venous blood sample were obtained from each subjects. FBS （fasting blood glucose）, fructosamine （glycemic control parameter） were determined （spectrophotometry method, （pars azmoon, Iran）, nitroblue tetrazoline method respectively）.serum zinc level with colorimetric method （Biorex-UK） and serum iron with photometric method （pars azmoon, Iran） were determined. Statistical analysis using SPSS software performed. Significant levels considered as P 〈 0.05. According to this study there is statistically significant difference between serum levels of iron and zinc in patients with type 1 diabetes compared to controls .indeed serum level of iron and zinc had lower level in patient group toward controls. In patients group, there are a positive correlation between age and decreased level of serum zinc （P 〈 0.05）. Also there was a significant negative correlation between the glycemic control status and serum zinc. Other studied parameters concluded BMI （body mass index）, Weight and height have not significant difference between groups. The decrease in serum iron and zinc level in women with type 1 diabetes may be related to low dietary intake or increased excretion of micro minerals or the presence of confounding factors that require more extensive intervention studies to confirm it.展开更多
文摘Pseudomonas aeruginosa (P. aeroginosa) is one of the opportunistic pathogens, which is the main cause of prevalent hospital infections worldwide. The aim of this study was to determine the prevalence of antibiotic resistance pattern against P. aeroginosa from clinical samples in our population. This study was performed during March 2009 to September 2011. During this period 233 clinical isolated samples from hospital patients were examined. In these studies, different strains of P. aeroginosa were isolated from samples, then microbiologically tested. Bacterial susceptibility was performed by the disc-diffusion tests with Kirby Baur disc diffusion tests in Muller-Hinto environment. Our results showed maximum antibiotic resistance (99.5%) of P. aeruginosa against Trimetoprime Solfametoxasole and Ciprofloxacin (55.33%), Amikacin (61%), Imipenem (33%), which were identified as the most effective antibiotics in this study. In conclusion, indeed most Pseudomonas aeruginosa strains infections are treated as soon as possible due to their severe resistance against antibiotics. So, we have to apply an accurate antibiotic treatment discipline, according to the finding, based on antibiogram, in order to prevent its spread and also, monitoring and optimization of antimicrobial use should be considered carefully.
文摘It seems that defects on micro-minerals levels have an etiologic role involved in type 1 diabetes mellitus pathogenicity. The aim of our study were to evaluate the serum levels of zinc and iron and investigate their possible relationship between these biochemical parameters with demographic conditions and glycemic control in patients with type 1 diabetes mellitus disorder. In this case-control based study, 68 female with type 1 diabetes mellitus with a mean age of 52.2 ±2 as case group and 122 healthy women as a control group with a mean age of 49/4 ±3/2 were investigated .for biochemical analysis ,10 mL fasting venous blood sample were obtained from each subjects. FBS （fasting blood glucose）, fructosamine （glycemic control parameter） were determined （spectrophotometry method, （pars azmoon, Iran）, nitroblue tetrazoline method respectively）.serum zinc level with colorimetric method （Biorex-UK） and serum iron with photometric method （pars azmoon, Iran） were determined. Statistical analysis using SPSS software performed. Significant levels considered as P 〈 0.05. According to this study there is statistically significant difference between serum levels of iron and zinc in patients with type 1 diabetes compared to controls .indeed serum level of iron and zinc had lower level in patient group toward controls. In patients group, there are a positive correlation between age and decreased level of serum zinc （P 〈 0.05）. Also there was a significant negative correlation between the glycemic control status and serum zinc. Other studied parameters concluded BMI （body mass index）, Weight and height have not significant difference between groups. The decrease in serum iron and zinc level in women with type 1 diabetes may be related to low dietary intake or increased excretion of micro minerals or the presence of confounding factors that require more extensive intervention studies to confirm it.
