The relationship between neurons of the thalamic reticular nucleus (TRN) and relay neurons of the thalamic nuclei was studied. Activation of the TRN neurons was shown to abate activity of relay neurons. This evidence ...The relationship between neurons of the thalamic reticular nucleus (TRN) and relay neurons of the thalamic nuclei was studied. Activation of the TRN neurons was shown to abate activity of relay neurons. This evidence was obtained by stimulation of the TRN and the neocortex and, by introduction of small doses of nembutal as well. Suppression of the relay neuronal activity by the TRN neurons is supposed to occur monosynaptically. It has been also revealed that neuronal activity of the TRN enhances in a clonic phase of seizures generated by stimulation of the hippocampus and as soon as the electroencephalographic seizure reactions disappear. The suppression of limbic motor seizures is obviously related to the process of potentiation in GABAergic synapses of thalamocortical networks. Thus, stimulation of the TRN appears to be a rather valuable methodical tool that can open up prospects in the development of new “anticonvulsive” strategies in the treated of temporal lobe epilepsy.展开更多
The main objective of the study was to determine the effect of gestation and postgestation periods on development and course of seizure activity. The data obtained in the study showed that i) there is a reduction of b...The main objective of the study was to determine the effect of gestation and postgestation periods on development and course of seizure activity. The data obtained in the study showed that i) there is a reduction of both EEG and behavioral seizures during gestation in the presence of hippocampal epileptogenic locus (kindling model);ii) suppression of audiogenic seizures occurs in gestation, and development of audiogenic kindling and decrease of seizure reactions occur in the pseudogestation state. It is assumed that in gestation period the intensification of the possible endogenous inhibitory mechanisms follows the course of seizure activity.展开更多
文摘The relationship between neurons of the thalamic reticular nucleus (TRN) and relay neurons of the thalamic nuclei was studied. Activation of the TRN neurons was shown to abate activity of relay neurons. This evidence was obtained by stimulation of the TRN and the neocortex and, by introduction of small doses of nembutal as well. Suppression of the relay neuronal activity by the TRN neurons is supposed to occur monosynaptically. It has been also revealed that neuronal activity of the TRN enhances in a clonic phase of seizures generated by stimulation of the hippocampus and as soon as the electroencephalographic seizure reactions disappear. The suppression of limbic motor seizures is obviously related to the process of potentiation in GABAergic synapses of thalamocortical networks. Thus, stimulation of the TRN appears to be a rather valuable methodical tool that can open up prospects in the development of new “anticonvulsive” strategies in the treated of temporal lobe epilepsy.
文摘The main objective of the study was to determine the effect of gestation and postgestation periods on development and course of seizure activity. The data obtained in the study showed that i) there is a reduction of both EEG and behavioral seizures during gestation in the presence of hippocampal epileptogenic locus (kindling model);ii) suppression of audiogenic seizures occurs in gestation, and development of audiogenic kindling and decrease of seizure reactions occur in the pseudogestation state. It is assumed that in gestation period the intensification of the possible endogenous inhibitory mechanisms follows the course of seizure activity.
