ain can be defined as an unpleasant sensory and emotional experience caused by either actual or potential tissue damage or even resemble that unpleasant experience.For years,science has sought to find treatment altern...ain can be defined as an unpleasant sensory and emotional experience caused by either actual or potential tissue damage or even resemble that unpleasant experience.For years,science has sought to find treatment alternatives,with minimal side effects,to relieve pain.However,the currently available pharmacological options on the market show significant adverse events.Therefore,the search for a safer and highly efficient analgesic treatment has become a priority.Stem cells(SCs)are non-specialized cells with a high capacity for replication,self-renewal,and a wide range of differentiation possibilities.In this review,we provide evidence that the immune and neuromodulatory properties of SCs can be a valuable tool in the search for ideal treatment strategies for different types of pain.With the advantage of multiple administration routes and dosages,therapies based on SCs for pain relief have demonstrated meaningful results with few downsides.Nonetheless,there are still more questions than answers when it comes to the mechanisms and pathways of pain targeted by SCs.Thus,this is an evolving field that merits further investigation towards the development of SCbased analgesic therapies,and this review will approach all of these aspects.展开更多
基金Conselho Nacional de Desenvolvimento Científico e Tecnológico,CNPq#203112/2020-2,#307852/2019-9,#309633/2021-4,#405027/2021-4,and#427946/2018-2+3 种基金PRONEX grant supported by SETI/Fundação Araucária and MCTI/CNPq,and Governo do Estado do Paraná(agreement#014/2017)Fundação Araucária(PBA/PROPPG 13/2021 agreements#276/2022-PBA and#250/2022-PBA)Financiadora de Estudos e Projetos-FINEPand CAPES(finance code#001).
文摘ain can be defined as an unpleasant sensory and emotional experience caused by either actual or potential tissue damage or even resemble that unpleasant experience.For years,science has sought to find treatment alternatives,with minimal side effects,to relieve pain.However,the currently available pharmacological options on the market show significant adverse events.Therefore,the search for a safer and highly efficient analgesic treatment has become a priority.Stem cells(SCs)are non-specialized cells with a high capacity for replication,self-renewal,and a wide range of differentiation possibilities.In this review,we provide evidence that the immune and neuromodulatory properties of SCs can be a valuable tool in the search for ideal treatment strategies for different types of pain.With the advantage of multiple administration routes and dosages,therapies based on SCs for pain relief have demonstrated meaningful results with few downsides.Nonetheless,there are still more questions than answers when it comes to the mechanisms and pathways of pain targeted by SCs.Thus,this is an evolving field that merits further investigation towards the development of SCbased analgesic therapies,and this review will approach all of these aspects.
