Our study investigated whether the f amilial aggregation of glioma is due to environmental or genetic effects and it investigated and compared the risk to spouses and firs t-degree relatives(FDR)of patients with prima...Our study investigated whether the f amilial aggregation of glioma is due to environmental or genetic effects and it investigated and compared the risk to spouses and firs t-degree relatives(FDR)of patients with primary brain tumou rs(PBT)for developing both PBT and the risk for other types of cancer.Al l PBT patients identified in Sweden f rom 1958-97in The Swedish Cancer Reg istry(SCR)were linked to the nationwide Swedish Fam ily Database,including persons in S weden born from 1932-97.The cohorts of spouses and FDR were linked to the SCR to identify observed cases of PBT and other cancer.S tandardised incidence ratios(SIR)were calculated using the incidence rates from SCR as the reference.We found that there were no increased risks for any specific type of PBT in the cohort of spouses.In the FDR cohort,generally the risk for a PBT was significantly increased by 2to 3times for the same h istopathology as the probands.Spouses of PBT patients had an increased risk of skin cancer.We conclude that FDR,not spouses,have a significantly increased risk,which indicates a genetic origin of the familial aggrega tion of brain展开更多
文摘Our study investigated whether the f amilial aggregation of glioma is due to environmental or genetic effects and it investigated and compared the risk to spouses and firs t-degree relatives(FDR)of patients with primary brain tumou rs(PBT)for developing both PBT and the risk for other types of cancer.Al l PBT patients identified in Sweden f rom 1958-97in The Swedish Cancer Reg istry(SCR)were linked to the nationwide Swedish Fam ily Database,including persons in S weden born from 1932-97.The cohorts of spouses and FDR were linked to the SCR to identify observed cases of PBT and other cancer.S tandardised incidence ratios(SIR)were calculated using the incidence rates from SCR as the reference.We found that there were no increased risks for any specific type of PBT in the cohort of spouses.In the FDR cohort,generally the risk for a PBT was significantly increased by 2to 3times for the same h istopathology as the probands.Spouses of PBT patients had an increased risk of skin cancer.We conclude that FDR,not spouses,have a significantly increased risk,which indicates a genetic origin of the familial aggrega tion of brain
