All the original references were provided by the Nobel Laureate Youyou Tu. The publication process involving the discovery of artemisinin was collected and sorted by her first Ph D student, Associate Professor Man-Yua...All the original references were provided by the Nobel Laureate Youyou Tu. The publication process involving the discovery of artemisinin was collected and sorted by her first Ph D student, Associate Professor Man-Yuan Wang. Through the publication of this article, the journal expects to provide a reference to the scientists who dedicated to the research of artemisinin, especially those who are interested in the discovery process of artemisinin.展开更多
Objective:To explore the effects of arteannuin B,arteannuic acid and scopoletin on the pharmacokinetics of artemisinin in mice.Methods:Artemisinin and a combination of artemisinin,arteannuin B,arteannuic acid and scop...Objective:To explore the effects of arteannuin B,arteannuic acid and scopoletin on the pharmacokinetics of artemisinin in mice.Methods:Artemisinin and a combination of artemisinin,arteannuin B,arteannuic acid and scopoletin were administered together to mice via oral administration.Blood samples were collected at different time intervals and pretreated by liquid-liquid extraction.The contents of four compounds in mouse plasma were determined by a validated HPLC-MS/MS method.Results:Compared to single artemisinin group,the C_(max) values from the combination group rose from 947 ng/mL to 1 254 ng/mL.AUC_((0-t))(2 371 h·ng/mL) was significantly higher than that from single artemisinin group(747 h·ng/mL).The peak time lag and the CL values reduced at a proportion of 66%.Conclusions:Arteannuin B,arteannuic acid and scopoletin can markedly affect the pharmacokinetics of artemisinin.展开更多
文摘All the original references were provided by the Nobel Laureate Youyou Tu. The publication process involving the discovery of artemisinin was collected and sorted by her first Ph D student, Associate Professor Man-Yuan Wang. Through the publication of this article, the journal expects to provide a reference to the scientists who dedicated to the research of artemisinin, especially those who are interested in the discovery process of artemisinin.
基金supported by the National Natural Science Foundation of China (No.81573682 and No.81102752)the Beijing Natural Science Foundation (No.2112010)
文摘Objective:To explore the effects of arteannuin B,arteannuic acid and scopoletin on the pharmacokinetics of artemisinin in mice.Methods:Artemisinin and a combination of artemisinin,arteannuin B,arteannuic acid and scopoletin were administered together to mice via oral administration.Blood samples were collected at different time intervals and pretreated by liquid-liquid extraction.The contents of four compounds in mouse plasma were determined by a validated HPLC-MS/MS method.Results:Compared to single artemisinin group,the C_(max) values from the combination group rose from 947 ng/mL to 1 254 ng/mL.AUC_((0-t))(2 371 h·ng/mL) was significantly higher than that from single artemisinin group(747 h·ng/mL).The peak time lag and the CL values reduced at a proportion of 66%.Conclusions:Arteannuin B,arteannuic acid and scopoletin can markedly affect the pharmacokinetics of artemisinin.
