A large number of populations are living with diabetes, which is the most common endocrine disorder which isclassified into Type-I and Type-II diabetes. Diabetes is one of the listed diseases specified in Section 3 of...A large number of populations are living with diabetes, which is the most common endocrine disorder which isclassified into Type-I and Type-II diabetes. Diabetes is one of the listed diseases specified in Section 3 of the Drugand Magic Remedies Act, 1954, where advertisement of drugs for certain diseases has been prohibited. It can bemanaged or controlled with proper diagnosis and treatment and by changing food habits. In addition to therapywith oral hypoglycemic agents, patients are also given subcutaneous insulin injections which is traditionally usedin diabetes therapy. This multi-dose injectable therapy has relatively low patient compliance. To avoid theassociated drawbacks with this therapy, several other delivery techniques, including oral, buccal, rectal, transdermal and pulmonary routes were investigated for effective insulin delivery. Several novel techniques along withnovel devices are discussed in this review. The recent development in insulin delivery and products going throughvarious phases of clinical trials are focused here. This review enumerates how the investigation, recent technology, and developments in research played a pivotal role in the treatment of diabetes in near future withalternative, safe, and efficient insulin delivery.展开更多
文摘A large number of populations are living with diabetes, which is the most common endocrine disorder which isclassified into Type-I and Type-II diabetes. Diabetes is one of the listed diseases specified in Section 3 of the Drugand Magic Remedies Act, 1954, where advertisement of drugs for certain diseases has been prohibited. It can bemanaged or controlled with proper diagnosis and treatment and by changing food habits. In addition to therapywith oral hypoglycemic agents, patients are also given subcutaneous insulin injections which is traditionally usedin diabetes therapy. This multi-dose injectable therapy has relatively low patient compliance. To avoid theassociated drawbacks with this therapy, several other delivery techniques, including oral, buccal, rectal, transdermal and pulmonary routes were investigated for effective insulin delivery. Several novel techniques along withnovel devices are discussed in this review. The recent development in insulin delivery and products going throughvarious phases of clinical trials are focused here. This review enumerates how the investigation, recent technology, and developments in research played a pivotal role in the treatment of diabetes in near future withalternative, safe, and efficient insulin delivery.
