Glass-fibre-reinforced polyetherketoneketone(PEKK-GF)shows great potential for application as a dental implant restoration material;however,its surface bioinertness and poor antibacterial properties limit its integrat...Glass-fibre-reinforced polyetherketoneketone(PEKK-GF)shows great potential for application as a dental implant restoration material;however,its surface bioinertness and poor antibacterial properties limit its integration with peri-implant soft tissue,which is critical in the long-term success of implant restoration.Herein,functional magnesium(Mg)and silver(Ag)ions were introduced into PEKK-GF by plasma immersion ion implantation(PIII).Surface characterization confirmed that the surface morphology of PEKK-GF was not visibly affected by PIII treatment.Further tests revealed that PIII changed the wettability and electrochemical environment of the PEKK-GF surface and enabled the release of Mg^(2+)and Ag^(+)modulated by Giavanni effect.In vitro experiments showed that Mg/Ag PIII-treated PEKK-GF promoted the proliferation and adhesion of human gingival fibroblasts and upregulated the expression of adhesion-related genes and proteins.In addition,the treated samples inhibited the metabolic viability and adhesion of Streptococcus mutans and Porphyromonas gingivalis on their surfaces,distorting bacterial morphology.Mg/Ag PIII surface treatment improved the soft tissue integration and antibacterial activities of PEKK-GF,which will further support and broaden its adoption in dentistry.展开更多
基金Qiang Wei(State Key Laboratory of Oral Diseases,West China Hospital of Stomatology,Sichuan University)for guidance in using scanning electron microscope(No.2020C017)and 3D profilometer(No.2020ACA0).
文摘Glass-fibre-reinforced polyetherketoneketone(PEKK-GF)shows great potential for application as a dental implant restoration material;however,its surface bioinertness and poor antibacterial properties limit its integration with peri-implant soft tissue,which is critical in the long-term success of implant restoration.Herein,functional magnesium(Mg)and silver(Ag)ions were introduced into PEKK-GF by plasma immersion ion implantation(PIII).Surface characterization confirmed that the surface morphology of PEKK-GF was not visibly affected by PIII treatment.Further tests revealed that PIII changed the wettability and electrochemical environment of the PEKK-GF surface and enabled the release of Mg^(2+)and Ag^(+)modulated by Giavanni effect.In vitro experiments showed that Mg/Ag PIII-treated PEKK-GF promoted the proliferation and adhesion of human gingival fibroblasts and upregulated the expression of adhesion-related genes and proteins.In addition,the treated samples inhibited the metabolic viability and adhesion of Streptococcus mutans and Porphyromonas gingivalis on their surfaces,distorting bacterial morphology.Mg/Ag PIII surface treatment improved the soft tissue integration and antibacterial activities of PEKK-GF,which will further support and broaden its adoption in dentistry.
