Effect of aqueous extract of Murraya koenigii on haematological,hormonal and lipid profile of Albino rats

Objective:To investigate the effect of aqueous extract of Murraya koenigii leaves on some haematological,hormonal and serum lipid parameters in rats.Methods:We evaluated whether oral administration of Murraya koenigii affected the haematological,hormonal and lipid parameters.After 7 days of oral administration of 250 mg/kg and 500 mg/kg body weight,other profiles were investigated.Results:The results showed that the extract administered significantly increased(P<0.05)packed cell volume,haemoglobin concentration,red blood cell,mean corpuscular hemoglobin,mean corpuscular hemoglobin concentration,mean corpuscular volume and decreased the platelet count(P<0.05)at the dose of 250 mg/kg and 500 mg/kg body weight when compared with control.The extract significantly increased(P<0.05)white blood cell count at all doses administered when compared with control.Results showed that thyronine and thyroxine were increased,while thyroid stimulating hormone was decreased significantly(P<0.05)at high doses compared.The recorded data in the present study showed that the testosterone value was reduced significantly(P<0.05)from control value.Also the extract significantly reduced(P<0.05)the total cholesterol concentration and low density lipoproteins cholesterol concentration in the serum while it had no significant effect on serum high density lipoprotein cholesterol concentration at all doses administered.Conclusions:This study suggests that the extracts may have beneficial effect on serum cholesterol concentration,can act as a stimulant to thyroid functions as well as in anemia and immunity dependent disorders and also as a potent contraceptive.